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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD28

Summary for CD28

Gene information	Gene symbol	CD28
	Ensembl ID	ENSG00000178562
	Entrez ID	940
	Gene name	CD28 molecule
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P10747

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Dataset with differentially expressed gene: CD28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.375439	5.57e-39

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Expression of CD28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD28	hsa-miR-4659a-3p	96.7516	NM_001243077
CD28	hsa-miR-4659b-3p	96.7516	NM_001243077
CD28	hsa-miR-552-5p	92.5079	NM_001243077
CD28	hsa-miR-3661	91.1058	NM_006139
CD28	hsa-miR-24-3p	91.0112	NM_001243077
CD28	hsa-miR-5787	90.6768	NM_006139
CD28	hsa-miR-4505	90.6768	NM_006139
CD28	hsa-miR-631	90.3112	NM_006139
CD28	hsa-miR-202-5p	89.2104	NM_001243077
CD28	hsa-miR-520a-5p	89.0939	NM_001243077
CD28	hsa-miR-525-5p	89.0939	NM_001243077
CD28	hsa-miR-3199	87.8064	NM_006139
CD28	hsa-miR-8052	87.8064	NM_006139
CD28	hsa-miR-4782-5p	86.7687	NM_001243077
CD28	hsa-miR-5706	86.7687	NM_001243077
CD28	hsa-miR-766-3p	85.907	NM_006139
CD28	hsa-miR-4531	85.6251	NM_006139
CD28	hsa-miR-4481	84.2046	NM_006139
CD28	hsa-miR-4264	84.1839	NM_006139
CD28	hsa-miR-224-5p	84.1748	NM_006139
CD28	hsa-miR-4698	83.5641	NM_006139
CD28	hsa-miR-337-3p	83.3762	NM_001243077
CD28	hsa-miR-95-5p	82.7478	NM_006139
CD28	hsa-miR-6811-3p	81.4114	NM_006139
CD28	hsa-miR-4310	81.1099	NM_006139
CD28	hsa-miR-5692a	81.0698	NM_001243077
CD28	hsa-miR-548l	80.5597	NM_006139
CD28	hsa-miR-383-5p	80.2736	NM_006139
CD28	hsa-miR-4753-3p	80.0829	NM_001243077

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Motifs and transcription factors (TFs) regulating CD28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD28	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
CD28	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
CD28	transfac_pro__M08803	CREM (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."