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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: CD247

Summary for CD247

Gene informationGene symbol

CD247

Ensembl ID

ENSG00000198821

Entrez ID

919

Gene nameCD247 molecule
SynonymsCD3-ZETA|CD3H|CD3Q|CD3Z|CD3ZETA|TCRZ
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: CD247

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostCD8+ T cells0.2795632.27e-35

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells0.2685260.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD8+ T cells0.2704761.44e-35

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostNK cells-0.4014692.24e-44

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreNK cells0.3322961.01e-26

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preCD8+ T cells0.2810040.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preNK cells0.2975860.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD8+ T cells0.4257971.72e-03

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD8+ T cells0.2661230.00e+00

GSE164237

patientsPeripheral blood mononuclear cellsMelanomaAdvanced stages of melanoma ImmunotherapypembrolizumabpreCD8+ T cells-0.2605410.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)postNK cells-0.5308890.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreCD8+ T cells0.2919072.85e-19

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostNK cells0.6098566.09e-39

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD4+ T cells-0.3236141.13e-02

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreNK cells-0.3973241.51e-23

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Expression of CD247 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CD247

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD247

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CD247hsa-miR-486-5p92.8813NM_198053
CD247hsa-miR-3922-3p92.6904NM_198053
CD247hsa-miR-491-3p90.559NM_000734
CD247hsa-miR-317690.3112NM_198053
CD247hsa-miR-6874-5p87.2677NM_198053
CD247hsa-miR-6867-5p86.1703NM_198053
CD247hsa-miR-6500-5p83.4026NM_198053
CD247hsa-miR-4633-3p83.4026NM_198053
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Motifs and transcription factors (TFs) regulating CD247

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CD247jaspar__MA0063.2NKX2-5 (directAnnotation).
CD247swissregulon__hs__HBP1HBP1 (directAnnotation).
CD247swissregulon__hs__CEBPBCEBPB (directAnnotation).
CD247metacluster_137.2ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
CD247metacluster_145.10ZNF24 (directAnnotation).
CD247metacluster_157.2ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
CD247transfac_pro__M05538ZNF536 (inferredBy_Orthology).
CD247metacluster_82.5ZKSCAN8; ZNF205; ZNF227; ZNF594 (directAnnotation).
CD247transfac_pro__M05403ADNP2 (inferredBy_Orthology).
CD247tfdimers__MD00350CRX; POU2F1 (directAnnotation).
CD247taipale__Esrra_DBD_TTCAAGGTCAN_reprESRRA (inferredBy_Orthology).
CD247tfdimers__MD00192CHURC1 (directAnnotation).
CD247transfac_pro__M00655ETV4 (directAnnotation).
CD247swissregulon__hs__SPI1SPI1 (directAnnotation).
CD247transfac_pro__M02269FEV (directAnnotation).
CD247hocomoco__TYY2_HUMAN.H11MO.0.DYY2 (directAnnotation).
CD247metacluster_141.4GLIS2 (directAnnotation).
CD247taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_reprETV2; SOX15 (directAnnotation).
CD247hdpi__FLI1FLI1 (directAnnotation).
CD247taipale_tf_pairs__ETV7_NNGGAAGTGCTTCCNN_HTETV7 (directAnnotation).
CD247metacluster_196.2MECOM; NR2C1; NR2C1; PPARD; PPARD; PRDM16; RARA; RARA; RARB; RARB; RARG; RARG; RORB; RORB; RORC; RORC; RUNX1; RXRA; RXRA; RXRB; RXRB; RXRG; RXRG; RXRG; RXRG; THRB; THRB (directAnnotation). RXRA (inferredBy_Orthology).
CD247kznf__ZNF573_Imbeault2017_OM_RCADEZNF573 (directAnnotation).
CD247transfac_pro__M04841RFX5 (directAnnotation).
CD247transfac_pro__M05913ZIM3 (directAnnotation).
CD247tfdimers__MD00362ARID3A; BCL6 (directAnnotation).
CD247transfac_pro__M06913ZNF256 (directAnnotation).
CD247jaspar__MA1645.1NKX2-2 (directAnnotation).
CD247transfac_pro__M05939ZNF471 (directAnnotation).
CD247kznf__ZNF45_Imbeault2017_RP_ChIP-seqZNF45 (directAnnotation).
CD247tfdimers__MD00174PDX1; STAT6 (directAnnotation).
CD247tfdimers__MD00180MAFA (directAnnotation).
CD247tfdimers__MD00147ELF5; TFAP2C (directAnnotation).
CD247transfac_pro__M06895ZFP3 (inferredBy_Orthology).
CD247metacluster_141.13METTL14 (inferredBy_Orthology).
CD247tfdimers__MD00504ELF1; NFIA; NFIC (directAnnotation).
CD247transfac_pro__M01119ZBTB33 (directAnnotation).
CD247transfac_pro__M01660GABPA (directAnnotation).
CD247metacluster_90.5NR5A2; NR5A2 (directAnnotation). ESRRB; NR5A1; NR5A1; NR5A1; NR5A2; NR5A2; NR5A2 (inferredBy_Orthology).
CD247transfac_pro__M07420HES1 (directAnnotation).
CD247hdpi__SMAD4SMAD4 (directAnnotation).
CD247kznf__ZNF184_Schmitges2016_RCADEZNF184 (directAnnotation).
CD247hocomoco__PO5F1_HUMAN.H11MO.1.APOU5F1 (directAnnotation).
CD247transfac_pro__M06897ZNF789 (directAnnotation).
CD247taipale_tf_pairs__ELK1_EVX1_RSCGGWANNNNYMATTA_CAP_reprELK1; EVX1 (directAnnotation).
CD247tfdimers__MD00297POU5F1; ZEB1 (directAnnotation).
CD247transfac_pro__M05698ZNF141 (directAnnotation).
CD247taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_reprETV7; GCM1 (directAnnotation).
CD247transfac_pro__M06382ZNF773 (directAnnotation).
CD247kznf__ZNF285_Imbeault2017_OM_MEMEZNF285 (directAnnotation).
CD247taipale_tf_pairs__TEAD4_MAX_RCATTCCNNNNNNNCACGTG_CAP_reprMAX; TEAD4 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
CD247"Muromonab"

DB00075

biotech
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."