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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: CD2

Summary for CD2

Gene informationGene symbol

CD2

Ensembl ID

ENSG00000116824

Entrez ID

914

Gene nameCD2 molecule
SynonymsSRBC
Gene typeprotein_coding
UniProtAcc

P06729


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Dataset with differentially expressed gene: CD2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreNK cells-0.2993520.00e+00

GSE169246_PacAteBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostNK cells0.2514722.27e-42

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD4+ T cells0.5611280.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreNK cells0.2749826.58e-16

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD8+ T cells0.6108980.00e+00

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD4+ T cells0.4078561.39e-12

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells0.4928945.89e-25

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD4+ T cells0.299085.77e-36

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells0.6521470.00e+00

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD8+ T cells0.4269250.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells-0.256845.54e-06

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreCD8+ T cells0.4284867.61e-43

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells0.4608520.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD8+ T cells0.5446260.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells0.7743970.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD4+ T cells-0.4380731.57e-03

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD8+ T cells0.2685443.27e-24

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreNK cells-0.394662.45e-26

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreCD8+ T cells-0.2984728.33e-23

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Expression of CD2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CD2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CD2hsa-miR-541-3p86.869NM_001767
CD2hsa-miR-654-5p86.869NM_001767
CD2hsa-miR-6792-5p83.1381NM_001767
CD2hsa-miR-216b-3p80.6558NM_001767
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Motifs and transcription factors (TFs) regulating CD2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CD2taipale_tf_pairs__MEIS1_SOX2_TGACAKNNNAACAATGN_CAP_reprMEIS1; SOX2 (directAnnotation).
CD2transfac_pro__M06141ZNF708 (directAnnotation).
CD2tfdimers__MD00275POU2F1; TFAP2A (directAnnotation).
CD2metacluster_30.1ZNF799; ZNF799 (directAnnotation).
CD2taipale_tf_pairs__HOXB2_ETV7_NSCGGAARNNNNNNMATTAN_CAP_reprETV7; HOXB2 (directAnnotation).
CD2transfac_pro__M06799ZSCAN12 (directAnnotation).
CD2tfdimers__MD00425ELF5; SMAD4 (directAnnotation).
CD2transfac_pro__M06042ZNF208 (directAnnotation).
CD2transfac_pro__M06763ZNF225 (directAnnotation).
CD2metacluster_52.5HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2 (directAnnotation).
CD2transfac_pro__M05779ZNF674 (directAnnotation).
CD2metacluster_52.10GTF3C2; ZNF436 (directAnnotation).
CD2taipale_tf_pairs__HOXB2_TBX21_NGGTGTGNNNNNTMATTWGCRN_CAP_reprHOXB2; TBX21 (directAnnotation).
CD2jaspar__MA0063.2NKX2-5 (directAnnotation).
CD2kznf__ZNF181_Imbeault2017_OM_RCADEZNF181 (directAnnotation).
CD2tfdimers__MD00066ELF1 (directAnnotation).
CD2transfac_pro__M05756ZNF470 (directAnnotation).
CD2transfac_pro__M05984ZNF586 (directAnnotation).
CD2metacluster_166.5ERG; ETV2; FLI1 (directAnnotation).
CD2jaspar__MA1956.1FOXO1 (directAnnotation).
CD2tfdimers__MD00053TCF3; ZNF354C (directAnnotation).
CD2transfac_pro__M06188ZNF135 (directAnnotation).
CD2transfac_pro__M06804PRDM15 (directAnnotation).
CD2metacluster_161.2LHX8 (directAnnotation).
CD2metacluster_168.11ZNF771; ZNF771 (directAnnotation).
CD2transfac_pro__M06798PRDM15 (directAnnotation).
CD2transfac_pro__M06759ZNF646 (directAnnotation).
CD2metacluster_79.12ZNF257 (directAnnotation).
CD2kznf__ZNF124_Imbeault2017_RP_RCADEZNF124 (directAnnotation).
CD2metacluster_161.15NKX3-1 (directAnnotation).
CD2taipale_cyt_meth__LHX5_NTCGTTAN_FL_methLHX5 (directAnnotation).
CD2metacluster_161.31PRRX2 (directAnnotation).
CD2metacluster_161.16NKX3-2 (directAnnotation).
CD2transfac_pro__M05986ZNF394 (inferredBy_Orthology).
CD2taipale_tf_pairs__MYBL1_ONECUT2_NAACGGNNATYGANN_CAP_reprMYBL1; ONECUT2 (directAnnotation).
CD2transfac_pro__M05852ZNF689 (directAnnotation).
CD2taipale_cyt_meth__LHX1_NTCGTTAN_eDBD_methLHX1 (directAnnotation).
CD2tfdimers__MD00410HMGA1; HMGA2; KLF4 (directAnnotation).
CD2taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAPETV1; TEAD4 (directAnnotation).
CD2metacluster_161.30BSX (directAnnotation).
CD2transfac_pro__M00731RUNX2 (directAnnotation).
CD2hocomoco__BPTF_HUMAN.H11MO.0.DBPTF (directAnnotation).
CD2transfac_pro__M04622NR4A1 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
CD2"Alefacept"

DB00092

biotech
CD2"Siplizumab"

DB06371

biotech
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."