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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CD160

Summary for CD160

Gene information	Gene symbol	CD160
	Ensembl ID	ENSG00000117281
	Entrez ID	11126
	Gene name	CD160 molecule
	Synonyms	BY55\|NK1\|NK28
	Gene type	protein_coding
	UniProtAcc	O95971

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Dataset with differentially expressed gene: CD160

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.42692	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	NK cells	-0.254097	3.00e-18

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Expression of CD160 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CD160

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	B cells	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	CD4+ T cells	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	CD8+ T cells	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	Malignant cells	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	Mono/Macro	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	NK cells	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	cDCs	GSE161801_IMiD	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	B cells	GSE169246_PacAteTissue	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	CD4+ T cells	GSE169246_PacAteTissue	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	Mast cells	GSE169246_PacAteTissue	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	Mono/Macro	GSE169246_PacAteTissue	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	NK cells	GSE169246_PacAteTissue	pre	resistant
CD160	NK cells	CPI-SS0879B8E95	CD160_TNFRSF14	CD160	TNFRSF14	False	NK cells	pDCs	GSE169246_PacAteTissue	pre	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CD160

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CD160	hsa-miR-4752	91.8772	NM_007053
CD160	hsa-miR-3121-5p	88.5794	NM_007053
CD160	hsa-miR-874-3p	86.5671	NM_007053
CD160	hsa-miR-6499-3p	85.3408	NM_007053
CD160	hsa-miR-7155-5p	83.7071	NM_007053
CD160	hsa-miR-6889-3p	82.2322	NM_007053
CD160	hsa-miR-6873-3p	81.7574	NM_007053
CD160	hsa-miR-6529-3p	80.542	NM_007053
CD160	hsa-miR-3679-3p	80.3333	NM_007053

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Motifs and transcription factors (TFs) regulating CD160

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CD160	transfac_pro__M06104	ZNF16 (directAnnotation).
CD160	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
CD160	taipale_tf_pairs__ETV2_NHLH1_NGCAGCTGCCGGAWRYN_CAP_repr	ETV2; NHLH1 (directAnnotation).
CD160	tfdimers__MD00129	CRX; NKX3-2 (directAnnotation).
CD160	transfac_public__M00237	AHR; ARNT (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."