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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCPG1

Summary for CCPG1

Gene information	Gene symbol	CCPG1
	Ensembl ID	ENSG00000260916
	Entrez ID	9236
	Gene name	cell cycle progression 1
	Synonyms	CPR8\|KIAA1254
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CCPG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.413776	4.86e-11
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.316768	4.84e-09
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	2.03685	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.31897	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.307724	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.764359	0.00e+00

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Expression of CCPG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCPG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCPG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCPG1	hsa-miR-513b-5p	99.2863	NM_020739
CCPG1	hsa-miR-3163	98.7929	NM_020739
CCPG1	hsa-miR-3124-3p	96.0708	NM_020739
CCPG1	hsa-miR-384	95.0633	NM_020739
CCPG1	hsa-miR-892c-5p	94.596	NM_020739
CCPG1	hsa-miR-4699-3p	94.3767	NM_020739
CCPG1	hsa-miR-545-3p	94.1173	NM_020739
CCPG1	hsa-miR-7161-5p	93.6176	NM_020739
CCPG1	hsa-miR-887-3p	93.5481	NM_020739
CCPG1	hsa-miR-6875-3p	93.5375	NM_020739
CCPG1	hsa-miR-498-5p	92.3322	NM_020739
CCPG1	hsa-miR-670-3p	92.1386	NM_020739
CCPG1	hsa-miR-512-5p	92.0009	NM_001204450
CCPG1	hsa-miR-577	90.6621	NM_020739
CCPG1	hsa-miR-548u	90.5916	NM_020739
CCPG1	hsa-miR-6828-3p	88.9764	NM_020739
CCPG1	hsa-miR-12119	88.8016	NM_001204450
CCPG1	hsa-miR-19a-3p	88.3733	NM_020739
CCPG1	hsa-miR-19b-3p	88.3733	NM_020739
CCPG1	hsa-miR-125b-2-3p	87.7878	NM_020739
CCPG1	hsa-miR-569	87.4595	NM_001204450
CCPG1	hsa-miR-340-5p	86.781	NM_020739
CCPG1	hsa-miR-6853-3p	85.7056	NM_020739
CCPG1	hsa-miR-5692a	85.4694	NM_020739
CCPG1	hsa-miR-411-5p	84.5872	NM_001204450
CCPG1	hsa-miR-330-3p	84.3594	NM_020739
CCPG1	hsa-miR-4501	84.1891	NM_020739
CCPG1	hsa-miR-103a-2-5p	84.1427	NM_001204450
CCPG1	hsa-miR-103a-1-5p	84.1427	NM_001204450
CCPG1	hsa-miR-2355-3p	83.0236	NM_020739
CCPG1	hsa-miR-4457	82.714	NM_020739
CCPG1	hsa-miR-224-5p	82.5628	NM_020739
CCPG1	hsa-miR-3156-5p	82.2943	NM_020739
CCPG1	hsa-miR-8485	82.2026	NM_020739
CCPG1	hsa-miR-5699-5p	81.1974	NM_020739
CCPG1	hsa-miR-4422	80.1171	NM_020739

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Motifs and transcription factors (TFs) regulating CCPG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCPG1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CCPG1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
CCPG1	transfac_pro__M01299	MECP2 (directAnnotation).
CCPG1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CCPG1	transfac_pro__M06035	ZNF749 (directAnnotation).
CCPG1	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CCPG1	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
CCPG1	jaspar__MA1596.1	ZNF460 (directAnnotation).
CCPG1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
CCPG1	metacluster_22.29	NFE2 (directAnnotation).
CCPG1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CCPG1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
CCPG1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CCPG1	transfac_pro__M04826	EP300 (directAnnotation).
CCPG1	transfac_pro__M04844	MAX (directAnnotation).
CCPG1	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CCPG1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CCPG1	transfac_pro__M06786	ZNF646 (directAnnotation).
CCPG1	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
CCPG1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CCPG1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CCPG1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CCPG1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
CCPG1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
CCPG1	hdpi__TP73	TP73 (directAnnotation).
CCPG1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CCPG1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
CCPG1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
CCPG1	transfac_pro__M04950	EGR1 (directAnnotation).
CCPG1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
CCPG1	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
CCPG1	transfac_pro__M02089	E2F3 (directAnnotation).
CCPG1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CCPG1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CCPG1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CCPG1	tfdimers__MD00483	ZBTB14 (directAnnotation).
CCPG1	cisbp__M07938	E2F1 (directAnnotation).
CCPG1	cisbp__M00968	MTF2 (directAnnotation).
CCPG1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CCPG1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CCPG1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CCPG1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CCPG1	jaspar__MA1122.1	TFDP1 (directAnnotation).
CCPG1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."