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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: CCNC

Summary for CCNC

Gene informationGene symbol

CCNC

Ensembl ID

ENSG00000112237

Entrez ID

892

Gene namecyclin C
SynonymsCycC
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: CCNC

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells0.3855091.51e-28

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.2823320.00e+00

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells0.3235825.92e-40

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreMalignant cells-0.2620520.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.3267521.22e-12

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Expression of CCNC in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CCNC

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCNC

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CCNChsa-miR-432897.9795NM_005190
CCNChsa-miR-469897.7772NM_001013399
CCNChsa-miR-477596.8379NM_005190
CCNChsa-miR-548aw95.1854NM_005190
CCNChsa-miR-450b-5p94.8982NM_005190
CCNChsa-miR-345-3p93.9471NM_001013399
CCNChsa-miR-551b-5p93.5661NM_005190
CCNChsa-miR-579-3p91.7597NM_005190
CCNChsa-miR-664b-3p91.7597NM_005190
CCNChsa-miR-145-3p91.3071NM_005190
CCNChsa-miR-94390.723NM_001013399
CCNChsa-miR-32-5p90.1361NM_001013399
CCNChsa-miR-92a-3p90.1361NM_001013399
CCNChsa-miR-92b-3p90.1361NM_001013399
CCNChsa-miR-1250-3p90.0452NM_005190
CCNChsa-miR-216a-3p89.985NM_001013399
CCNChsa-miR-128-3p89.985NM_001013399
CCNChsa-miR-432589.8873NM_001013399
CCNChsa-miR-365889.2675NM_005190
CCNChsa-miR-133b88.8912NM_001013399
CCNChsa-miR-133a-3p88.8912NM_001013399
CCNChsa-miR-590-3p88.8124NM_005190
CCNChsa-miR-548c-3p88.6852NM_001013399
CCNChsa-miR-3681-3p88.5816NM_001013399
CCNChsa-miR-584-5p88.2126NM_005190
CCNChsa-miR-548d-3p87.2469NM_005190
CCNChsa-miR-548z87.2469NM_005190
CCNChsa-miR-548bb-3p87.2469NM_005190
CCNChsa-miR-548ac87.2469NM_005190
CCNChsa-miR-548h-3p87.2469NM_005190
CCNChsa-miR-203a-3p86.9172NM_001013399
CCNChsa-miR-670-5p86.5609NM_001013399
CCNChsa-miR-27b-3p86.538NM_005190
CCNChsa-miR-998586.538NM_005190
CCNChsa-miR-27a-3p86.538NM_005190
CCNChsa-miR-500a-5p86.5326NM_005190
CCNChsa-miR-366286.1008NM_001013399
CCNChsa-miR-127985.5119NM_001013399
CCNChsa-miR-25-3p85.2843NM_001013399
CCNChsa-miR-363-3p85.2843NM_001013399
CCNChsa-miR-367-3p85.2843NM_001013399
CCNChsa-miR-316385.1267NM_001013399
CCNChsa-miR-318584.0199NM_001013399
CCNChsa-miR-10522-5p84.0199NM_001013399
CCNChsa-miR-5582-3p83.5642NM_005190
CCNChsa-miR-806382.1773NM_001013399
CCNChsa-miR-181a-2-3p81.7861NM_005190
CCNChsa-miR-7849-3p81.5485NM_001013399
CCNChsa-miR-6718-5p81.1345NM_001013399
CCNChsa-miR-203b-5p81.1345NM_001013399
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Motifs and transcription factors (TFs) regulating CCNC

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CCNCtransfac_pro__M01861ATF1 (directAnnotation).
CCNCkznf__ZNF282_Imbeault2017_OM_RCADEZNF282 (directAnnotation).
CCNCmetacluster_7.8ZBTB7A; ZNF28 (directAnnotation).
CCNCmetacluster_35.7HINFP (inferredBy_Orthology).
CCNCmetacluster_98.1ZNF524 (directAnnotation).
CCNCmetacluster_2.8IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
CCNCtransfac_pro__M06292ZNF766 (directAnnotation).
CCNCtfdimers__MD00602MYB; STAT6 (directAnnotation).
CCNCtransfac_pro__M05513ZNF641 (inferredBy_Orthology).
CCNCtaipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAPELK1; FOXO1 (directAnnotation).
CCNCtaipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
CCNCmetacluster_34.3EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CCNCmetacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CCNChdpi__ETV4ETV4 (directAnnotation).
CCNCtaipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
CCNCtransfac_pro__M01298MECP2 (directAnnotation).
CCNCtransfac_pro__M04918EGR1 (directAnnotation).
CCNCmetacluster_7.13ZFX (directAnnotation).
CCNCmetacluster_144.3ZNF704; ZNF704 (directAnnotation).
CCNCtfdimers__MD00154MZF1; SREBF1 (directAnnotation).
CCNCkznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
CCNCmetacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CCNCcisbp__M00249WT1 (directAnnotation).
CCNCcisbp__M01863ZNF711 (inferredBy_Orthology).
CCNChomer__GGCGGGAARN_E2F6E2F6 (directAnnotation).
CCNCtaipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."