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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCL4L2

Summary for CCL4L2

Gene information	Gene symbol	CCL4L2
	Ensembl ID	ENSG00000282604
	Entrez ID	9560
	Gene name	C-C motif chemokine ligand 4 like 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8NHW4

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Dataset with differentially expressed gene: CCL4L2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	-0.455107	2.28e-20
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-1.29365	5.32e-10
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.707251	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.828267	8.97e-44
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-1.60397	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.619728	4.19e-27
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	-0.354538	4.64e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	-0.737641	2.36e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Malignant cells	-1.10738	8.76e-04
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-1.11946	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	0.902456	3.29e-05
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.603698	5.47e-10
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	2.80123	4.92e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	pDCs	1.25744	2.64e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.883183	1.50e-19
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	1.5556	3.37e-12

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Expression of CCL4L2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCL4L2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCL4L2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCL4L2	hsa-miR-6781-3p	89.5212	NM_001291472
CCL4L2	hsa-miR-4477b	89.3634	NM_001291470
CCL4L2	hsa-miR-584-3p	87.2986	NM_001291470
CCL4L2	hsa-miR-2682-3p	85.7828	NM_001291472
CCL4L2	hsa-miR-5583-5p	83.6452	NM_001291468
CCL4L2	hsa-miR-3129-3p	83.6452	NM_001291468
CCL4L2	hsa-miR-6081	83.4343	NM_001291469
CCL4L2	hsa-miR-3649	83.1286	NM_001291474
CCL4L2	hsa-miR-4456	82.2511	NM_001291469
CCL4L2	hsa-miR-561-3p	80.85	NM_001291468
CCL4L2	hsa-miR-6729-3p	80.164	NM_001291470

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Motifs and transcription factors (TFs) regulating CCL4L2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCL4L2	transfac_pro__M06133	ZNF17 (directAnnotation).
CCL4L2	swissregulon__mm__Cebpe	CEBPE (inferredBy_Orthology).
CCL4L2	kznf__ZNF26_Imbeault2017_OM_MEME	ZNF26 (directAnnotation).
CCL4L2	transfac_pro__M06671	ZNF285 (directAnnotation).
CCL4L2	taipale_tf_pairs__TEAD4_ONECUT2_RCATTCCNNATCGAYN_CAP_repr	ONECUT2; TEAD4 (directAnnotation).
CCL4L2	dbtfbs__ZKSCAN8_representative_N1	ZKSCAN8 (directAnnotation).
CCL4L2	taipale_tf_pairs__POU2F1_FOXO6_RMATATKCNNNNNNNNNNNNNNNNRWMAACA_CAP_repr	FOXO6; POU2F1 (directAnnotation).
CCL4L2	kznf__ZNF614_Imbeault2017_RP_ChIP-seq	ZNF614 (directAnnotation).
CCL4L2	hdpi__ZNF205	ZNF205 (directAnnotation).
CCL4L2	transfac_pro__M05643	ZNF879 (directAnnotation).
CCL4L2	transfac_pro__M06642	ZSCAN10 (directAnnotation).
CCL4L2	dbtfbs__CHAMP1_K562_ENCSR065XVO_merged_N1	CHAMP1 (directAnnotation).
CCL4L2	hdpi__ZNF238	ZBTB18 (directAnnotation).
CCL4L2	tfdimers__MD00209	MZF1; TBP (directAnnotation).
CCL4L2	taipale_tf_pairs__GCM1_TBX21_RGGTGWKNNNNNNNNNTNNCRTRNGGGN_CAP_repr	GCM1; TBX21 (directAnnotation).
CCL4L2	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
CCL4L2	transfac_pro__M05463	ZIM2 (directAnnotation).
CCL4L2	transfac_pro__M06852	ZNF549 (directAnnotation).
CCL4L2	tfdimers__MD00002	CRX (directAnnotation).
CCL4L2	metacluster_74.10	HNF1B (directAnnotation).
CCL4L2	metacluster_198.1	ZNF439 (directAnnotation).
CCL4L2	swissregulon__mm__Pbx1	PBX1 (inferredBy_Orthology).
CCL4L2	transfac_pro__M06077	ZNF716 (directAnnotation).
CCL4L2	transfac_pro__M05506	ZSCAN16 (directAnnotation).
CCL4L2	metacluster_89.5	ZKSCAN1 (directAnnotation). ZKSCAN1 (inferredBy_Orthology).
CCL4L2	tfdimers__MD00228	PDX1; TFAP4 (directAnnotation).
CCL4L2	dbtfbs__NCOA3_MCF-7_ENCSR573OJP_merged_N2	NCOA3 (directAnnotation).
CCL4L2	metacluster_86.5	ZNF324; ZNF418 (directAnnotation).
CCL4L2	taipale_tf_pairs__CUX1_SOX15_NATCRATNNNNNNNAACAATRS_CAP_repr	CUX1; SOX15 (directAnnotation).
CCL4L2	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
CCL4L2	transfac_pro__M06326	ZNF841 (directAnnotation).
CCL4L2	jaspar__MA1951.1	FOS (directAnnotation).
CCL4L2	swissregulon__hs__RUNX2	RUNX2 (directAnnotation).
CCL4L2	metacluster_23.5	WT1 (directAnnotation).
CCL4L2	transfac_pro__M06265	ZNF791 (directAnnotation).
CCL4L2	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
CCL4L2	transfac_pro__M04933	STAT3 (directAnnotation).
CCL4L2	metacluster_8.3	BCL11A; RUNX1; RUNX1; RUNX1; RUNX1; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3 (directAnnotation). CBFB; RUNX1; RUNX1; RUNX1; RUNX1; RUNX2; RUNX2; RUNX2; RUNX2; RUNX3; RUNX3; RUNX3 (inferredBy_Orthology).
CCL4L2	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
CCL4L2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
CCL4L2	transfac_pro__M06375	ZNF629 (inferredBy_Orthology).
CCL4L2	transfac_pro__M06807	SALL2 (inferredBy_Orthology).
CCL4L2	metacluster_172.27	DMRTC2 (directAnnotation).
CCL4L2	transfac_pro__M06353	ZNF782 (directAnnotation).
CCL4L2	transfac_pro__M06742	ZNF304 (directAnnotation).
CCL4L2	taipale_tf_pairs__GCM1_ELK1_RKRNRGGCGGAARCGGAAGNN_CAP_repr	ELK1; GCM1 (directAnnotation).
CCL4L2	kznf__CTCF_Transfac.7_Transfac	CTCF (directAnnotation).
CCL4L2	transfac_pro__M05791	ZNF517 (directAnnotation).
CCL4L2	transfac_pro__M05683	ZNF280A (directAnnotation).
CCL4L2	transfac_pro__M06115	ZNF28 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."