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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCL4

Summary for CCL4

Gene information	Gene symbol	CCL4
	Ensembl ID	ENSG00000277943
	Entrez ID	6351
	Gene name	C-C motif chemokine ligand 4
	Synonyms	Act-2\|AT744.1\|LAG1\|MIP-1-beta\|SCYA4
	Gene type	protein_coding
	UniProtAcc	P13236

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Dataset with differentially expressed gene: CCL4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.431127	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.309107	2.31e-21
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.386207	1.55e-39
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.542741	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	-0.402052	5.67e-22
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-1.2637	1.79e-14
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-1.42907	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.897197	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-1.23242	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.515595	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	-0.665439	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	-0.30958	3.14e-20
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	0.327267	1.48e-33
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	NK cells	-1.04218	4.27e-02
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.284007	1.18e-19
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	post	CD8+ T cells	-0.427581	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.353625	6.29e-26
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD4+ T cells	0.762862	3.12e-13
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	CD8+ T cells	1.38633	9.07e-28
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.722777	1.09e-31
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	CD8+ T cells	-0.279622	4.48e-25
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	NK cells	0.499635	9.69e-20
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	pDCs	0.526083	2.97e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	0.410286	9.69e-37
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.905505	7.16e-09
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	0.600997	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	NK cells	1.31931	2.14e-33
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.786925	2.97e-21
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	1.03541	1.10e-42
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	0.879951	1.90e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	2.35498	1.29e-34
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.591196	3.27e-28
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	CD8+ T cells	0.7502	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	0.423006	9.77e-11

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Expression of CCL4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCL4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Gene symbol	Cell type with DEG	Interaction ID	Interacting pair	Gene A	Gene B	Integrin	Interacting cell type1	Interacting cell type2	Dataset	Timepoint	Condition
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	Mono/Macro	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	CD8+ T cells	GSE169246_PacAteTissue	pre	resistant
CCL4	NK cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	pDCs	GSE169246_PacBlood	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	pDCs	GSE169246_PacBlood	post	resistant
CCL4	NK cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	cDCs	GSE169246_PacBlood	post	sensitive
CCL4	NK cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	pDCs	GSE169246_PacBlood	post	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	cDCs	GSE169246_PacBlood	post	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	pDCs	GSE169246_PacBlood	post	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD8+ T cells	GSE169246_PacBlood	pre	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	pDCs	GSE169246_PacBlood	pre	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	CD8+ T cells	GSE169246_PacBlood	pre	resistant
CCL4	Mono/Macro	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	Mono/Macro	CD8+ T cells	GSE169246_PacTissue	pre	sensitive
CCL4	NK cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	cDCs	GSE197268_Axi-cel	pre	resistant
CCL4	NK cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	pDCs	GSE197268_Axi-cel	pre	resistant
CCL4	NK cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	cDCs	GSE197268_Axi-cel	pre	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD4+ T cells	CD8+ T cells	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD4+ T cells	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD8+ T cells	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	Mono/Macro	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	Mono/Macro	CD8+ T cells	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	CD8+ T cells	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	Neutrophils	CD8+ T cells	GSE207422_Sin	post	resistant
CCL4	CD4+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD4+ T cells	CD8+ T cells	GSE207422_Sin	post	resistant
CCL4	CD4+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD4+ T cells	GSE207422_Sin	post	resistant
CCL4	CD4+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	CD4+ T cells	GSE207422_Sin	post	resistant
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD8+ T cells	GSE207422_Sin	post	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	pDCs	GSE207422_Sin	post	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	Mono/Macro	CD8+ T cells	GSE207422_Sin	post	sensitive
CCL4	CD8+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	NK cells	CD8+ T cells	GSE207422_Sin	post	sensitive
CCL4	CD4+ T cells	CPI-SS0D1D95883	CCL4_CCR5	CCL4	CCR5	False	CD8+ T cells	CD4+ T cells	PMID34715028	post	resistant

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCL4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCL4	hsa-miR-765	88.4438	NM_002984
CCL4	hsa-miR-1843	87.8677	NM_002984
CCL4	hsa-miR-20a-3p	86.0472	NM_002984
CCL4	hsa-miR-11181-3p	84.0507	NM_002984
CCL4	hsa-miR-5583-5p	83.6349	NM_002984
CCL4	hsa-miR-3129-3p	83.6349	NM_002984
CCL4	hsa-miR-4802-5p	83.3442	NM_002984
CCL4	hsa-miR-6729-3p	83.1289	NM_002984
CCL4	hsa-miR-561-3p	80.724	NM_002984

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Motifs and transcription factors (TFs) regulating CCL4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCL4	nitta__CG18619_TCGAAG20NGA_KH_RTGACGTCAT_m1_c3u	CREBL2 (inferredBy_Orthology).
CCL4	tfdimers__MD00209	MZF1; TBP (directAnnotation).
CCL4	transfac_pro__M06784	ZNF780B (directAnnotation).
CCL4	transfac_pro__M05791	ZNF517 (directAnnotation).
CCL4	metacluster_90.4	ESR1; ESR1; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRA; ESRRB; ESRRB; ESRRB; ESRRB; ESRRG; ESRRG; ESRRG; ESRRG; ESRRG; NR5A1; NR5A1; NR5A1; NR5A2; NR5A2; NR5A2; NR5A2; NR5A2; NR5A2 (directAnnotation). AR; ESR1; ESR2; ESRRA; ESRRA; ESRRA; ESRRB; ESRRB; ESRRB; ESRRB; ESRRG; ESRRG; ESRRG; ESRRG; ESRRG; NR3C1; NR3C2; NR5A1; NR5A2; NR5A2; NR5A2; NR5A2; NR5A2; PGR; RXRG (inferredBy_Orthology).
CCL4	transfac_pro__M05814	ZNF605 (directAnnotation).
CCL4	metacluster_33.1	IRX2; SIX1; SIX1; SIX1; SIX2; SIX2; SIX4; SIX4; SIX4; ZNF32; ZNF32 (directAnnotation). SIX1; SIX2; SIX2; SIX4 (inferredBy_Orthology).
CCL4	transfac_pro__M05393	ZBTB6 (inferredBy_Orthology).
CCL4	tfdimers__MD00425	ELF5; SMAD4 (directAnnotation).
CCL4	transfac_pro__M07981	ATF3 (inferredBy_Orthology).
CCL4	taipale_tf_pairs__GCM1_SOX2_RTRSGGGNNNATTGTKY_CAP_repr	GCM1; SOX2 (directAnnotation).
CCL4	cisbp__M00273	CRX (directAnnotation).
CCL4	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
CCL4	cisbp__M00311	PITX2 (directAnnotation).
CCL4	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
CCL4	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
CCL4	transfac_pro__M05854	ZNF619 (directAnnotation).
CCL4	dbtfbs__mm_TAL1_representative_N3	TAL1 (inferredBy_Orthology).
CCL4	jaspar__MA1951.1	FOS (directAnnotation).
CCL4	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
CCL4	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
CCL4	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
CCL4	transfac_public__M00041	ATF2; JUN (directAnnotation).
CCL4	transfac_pro__M06642	ZSCAN10 (directAnnotation).
CCL4	transfac_pro__M04746	E2F1 (directAnnotation).
CCL4	transfac_public__M00039	CREB1 (directAnnotation).
CCL4	metacluster_155.13	ZNF135 (directAnnotation).
CCL4	taipale__Esrra_DBD_TTCAAGGTCAN_repr	ESRRA (inferredBy_Orthology).
CCL4	transfac_pro__M05560	AEBP2 (directAnnotation).
CCL4	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
CCL4	cisbp__M01809	FOSL2 (inferredBy_Orthology).
CCL4	transfac_pro__M06469	ZNF441 (directAnnotation).
CCL4	transfac_pro__M07448	ZBED1 (directAnnotation).
CCL4	metacluster_22.42	MAFG (directAnnotation).
CCL4	transfac_pro__M05667	ZNF35 (directAnnotation).
CCL4	transfac_pro__M05463	ZIM2 (directAnnotation).
CCL4	transfac_pro__M04933	STAT3 (directAnnotation).
CCL4	tfdimers__MD00449	REL; YY1 (directAnnotation).
CCL4	taipale_cyt_meth__HSF5_AACRTTCTAGAAYGYT_eDBD_meth	HSF5 (directAnnotation).
CCL4	transfac_pro__M06897	ZNF789 (directAnnotation).
CCL4	transfac_pro__M06920	ZNF256 (directAnnotation).
CCL4	dbtfbs__NCOA3_MCF-7_ENCSR573OJP_merged_N2	NCOA3 (directAnnotation).
CCL4	metacluster_137.1	NFE2L1; NFE2L1; ZNF177 (directAnnotation).
CCL4	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
CCL4	tfdimers__MD00228	PDX1; TFAP4 (directAnnotation).
CCL4	tfdimers__MD00034	PDX1; SOX2 (directAnnotation).
CCL4	transfac_pro__M05765	ZNF684 (directAnnotation).
CCL4	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
CCL4	transfac_pro__M06661	ZNF426 (directAnnotation).
CCL4	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."