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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: CCL3L1

Summary for CCL3L1

Gene informationGene symbol

CCL3L1

Ensembl ID

ENSG00000277796

Entrez ID

6349

Gene nameC-C motif chemokine ligand 3 like 1
SynonymsD17S1718|G0S19-2|LD78BETA|SCYA3L|SCYA3L1|MGC12815
Gene typeprotein_coding
UniProtAcc

P16619


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Dataset with differentially expressed gene: CCL3L1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostMono/Macro-1.174112.10e-03

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro-0.9873541.40e-45

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro-0.4256271.75e-02

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMono/Macro-1.200170.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMono/Macro0.5212213.66e-02

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Expression of CCL3L1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to CCL3L1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)
Gene symbolCell type with DEGInteraction IDInteracting pairGene AGene BIntegrinInteracting cell type1Interacting cell type2DatasetTimepointCondition
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE161801_PI

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE169246_PacAteTissue

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseCD8+ T cellsMono/Macro

GSE169246_PacAteTissue

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE169246_PacAteTissue

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE169246_PacTissue

postresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalsecDCsMono/Macro

GSE169246_PacTissue

postresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE169246_PacTissue

postsensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalsecDCsMono/Macro

GSE169246_PacTissue

postsensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE169246_PacTissue

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalsecDCsMono/Macro

GSE169246_PacTissue

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE169246_PacTissue

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacrocDCs

GSE169246_PacTissue

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalsecDCsMono/Macro

GSE169246_PacTissue

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseCD8+ T cellsMono/Macro

GSE189460

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE189460

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacrocDCs

GSE189460

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseNK cellsMono/Macro

GSE189460

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalsecDCsMono/Macro

GSE189460

preresistant
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseCD8+ T cellsMono/Macro

GSE189460

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacroMono/Macro

GSE189460

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseMono/MacrocDCs

GSE189460

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalseNK cellsMono/Macro

GSE189460

presensitive
CCL3L1Mono/MacroCPI-SS0817CE2B3CCL3L1_CCR1CCL3L1CCR1FalsecDCsMono/Macro

GSE189460

presensitive
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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCL3L1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
CCL3L1hsa-miR-548aj-3p94.1534NM_001001437
CCL3L1hsa-miR-548x-3p94.1534NM_001001437
CCL3L1hsa-miR-548ah-3p93.5887NM_001001437
CCL3L1hsa-miR-548aq-3p93.5887NM_001001437
CCL3L1hsa-miR-548j-3p93.5887NM_001001437
CCL3L1hsa-miR-548ae-3p93.5887NM_001001437
CCL3L1hsa-miR-548am-3p93.5887NM_001001437
CCL3L1hsa-miR-5197-3p81.0723NM_001001437
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Motifs and transcription factors (TFs) regulating CCL3L1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
CCL3L1metacluster_5.1HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
CCL3L1metacluster_22.42MAFG (directAnnotation).
CCL3L1transfac_pro__M05667ZNF35 (directAnnotation).
CCL3L1transfac_pro__M04706RELA (directAnnotation).
CCL3L1transfac_pro__M06180ZNF445 (directAnnotation).
CCL3L1transfac_pro__M05791ZNF517 (directAnnotation).
CCL3L1taipale_cyt_meth__POU6F1_NTAATKAGSN_FL_methPOU6F1 (directAnnotation).
CCL3L1transfac_pro__M04933STAT3 (directAnnotation).
CCL3L1tfdimers__MD00449REL; YY1 (directAnnotation).
CCL3L1metacluster_155.13ZNF135 (directAnnotation).
CCL3L1metacluster_2.6IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
CCL3L1metacluster_8.3BCL11A; RUNX1; RUNX1; RUNX1; RUNX1; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX2; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3; RUNX3 (directAnnotation). CBFB; RUNX1; RUNX1; RUNX1; RUNX1; RUNX2; RUNX2; RUNX2; RUNX2; RUNX3; RUNX3; RUNX3 (inferredBy_Orthology).
CCL3L1yetfasco__TBP-TFIIA-TFIIB_1330GTF2B; TBPL2 (inferredBy_Orthology).
CCL3L1transfac_pro__M06375ZNF629 (inferredBy_Orthology).
CCL3L1transfac_pro__M06807SALL2 (inferredBy_Orthology).
CCL3L1tfdimers__MD00158DBP; ZNF354C (directAnnotation).
CCL3L1transfac_pro__M06830ZNF528 (directAnnotation).
CCL3L1transfac_pro__M05717ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
CCL3L1transfac_pro__M05884ZNF439 (directAnnotation).
CCL3L1transfac_pro__M02830ZSCAN26 (inferredBy_Orthology).
CCL3L1tfdimers__MD00217LTF; MZF1 (directAnnotation).
CCL3L1transfac_pro__M05574ZFP92 (directAnnotation).
CCL3L1transfac_public__M00285NFE2L1 (directAnnotation).
CCL3L1transfac_pro__M06326ZNF841 (directAnnotation).
CCL3L1metacluster_29.2BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
CCL3L1transfac_pro__M06265ZNF791 (directAnnotation).
CCL3L1transfac_pro__M05640ZNF735 (directAnnotation).
CCL3L1taipale__Esrra_DBD_TTCAAGGTCAN_reprESRRA (inferredBy_Orthology).
CCL3L1transfac_pro__M06557ZNF418 (directAnnotation).
CCL3L1tfdimers__MD00321FLI1; ING4 (directAnnotation).
CCL3L1metacluster_168.4ZNF652 (directAnnotation).
CCL3L1kznf__ZNF614_Imbeault2017_RP_ChIP-seqZNF614 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."