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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCL28

Summary for CCL28

Gene information	Gene symbol	CCL28
	Ensembl ID	ENSG00000151882
	Entrez ID	56477
	Gene name	C-C motif chemokine ligand 28
	Synonyms	CCK1\|MEC\|SCYA28
	Gene type	protein_coding
	UniProtAcc	Q9NRJ3

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Dataset with differentially expressed gene: CCL28

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.309152	4.99e-36

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Expression of CCL28 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCL28

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCL28

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCL28	hsa-miR-4795-3p	98.9634	NM_148672
CCL28	hsa-miR-4775	96.4788	NM_148672
CCL28	hsa-miR-126-5p	95.0873	NM_148672
CCL28	hsa-miR-3618	92.8634	NM_148672
CCL28	hsa-miR-3920	92.4249	NM_001301873
CCL28	hsa-miR-6853-3p	91.1878	NM_148672
CCL28	hsa-miR-561-3p	90.9982	NM_001301873
CCL28	hsa-miR-548ar-3p	90.8795	NM_148672
CCL28	hsa-miR-6780a-5p	90.0301	NM_148672
CCL28	hsa-miR-487a-5p	89.8379	NM_148672
CCL28	hsa-miR-487b-5p	89.8379	NM_148672
CCL28	hsa-miR-548a-3p	89.6903	NM_148672
CCL28	hsa-miR-548bc	89.6903	NM_148672
CCL28	hsa-miR-548az-3p	89.6903	NM_148672
CCL28	hsa-miR-548f-3p	89.6903	NM_148672
CCL28	hsa-miR-548e-3p	89.6903	NM_148672
CCL28	hsa-miR-4268	89.4784	NM_148672
CCL28	hsa-miR-593-3p	89.3649	NM_148672
CCL28	hsa-miR-6818-3p	89.2413	NM_148672
CCL28	hsa-miR-3689a-3p	88.9724	NM_148672
CCL28	hsa-miR-15b-3p	88.2548	NM_001301874
CCL28	hsa-miR-3139	88.2206	NM_148672
CCL28	hsa-miR-4266	87.6195	NM_001301873
CCL28	hsa-miR-3689c	87.4816	NM_148672
CCL28	hsa-miR-30b-3p	87.4816	NM_148672
CCL28	hsa-miR-1273h-5p	87.4816	NM_148672
CCL28	hsa-miR-3689b-3p	87.4816	NM_148672
CCL28	hsa-miR-6779-5p	87.4816	NM_148672
CCL28	hsa-miR-5692c	87.2645	NM_148672
CCL28	hsa-miR-5692b	87.2645	NM_148672
CCL28	hsa-miR-580-5p	87.1655	NM_001301874
CCL28	hsa-miR-4796-3p	86.8555	NM_148672
CCL28	hsa-miR-590-3p	86.113	NM_148672
CCL28	hsa-miR-21-3p	85.9997	NM_148672
CCL28	hsa-miR-4259	85.839	NM_148672
CCL28	hsa-miR-122b-3p	85.7681	NM_148672
CCL28	hsa-miR-1233-3p	85.2258	NM_148672
CCL28	hsa-miR-4505	84.958	NM_148672
CCL28	hsa-miR-5787	84.958	NM_148672
CCL28	hsa-miR-891b	84.5089	NM_148672
CCL28	hsa-miR-6739-3p	84.2242	NM_148672
CCL28	hsa-miR-2278	84.0008	NM_001301873
CCL28	hsa-miR-3688-3p	83.3407	NM_001301874
CCL28	hsa-miR-4670-3p	83.1231	NM_148672
CCL28	hsa-miR-3065-5p	82.9121	NM_148672
CCL28	hsa-miR-1285-3p	82.7596	NM_148672
CCL28	hsa-miR-30c-2-3p	82.4416	NM_148672
CCL28	hsa-miR-30c-1-3p	82.4416	NM_148672
CCL28	hsa-miR-6788-5p	82.4416	NM_148672
CCL28	hsa-miR-142-5p	82.3054	NM_001301873

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Motifs and transcription factors (TFs) regulating CCL28

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCL28	metacluster_44.7	NKX3-2 (directAnnotation).
CCL28	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CCL28	transfac_pro__M00716	ZBTB14 (directAnnotation).
CCL28	taipale_tf_pairs__MGA_DLX2_SYAATTANWGGTGYGA_CAP	DLX2; MGA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."