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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC88C

Summary for CCDC88C

Gene information	Gene symbol	CCDC88C
	Ensembl ID	ENSG00000015133
	Entrez ID	440193
	Gene name	coiled-coil domain containing 88C
	Synonyms	DAPLE\|HkRP2\|KIAA1509\|SCA40
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CCDC88C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.389869	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.289241	0.00e+00

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Expression of CCDC88C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC88C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC88C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC88C	hsa-miR-551b-5p	94.3023	NM_001080414
CCDC88C	hsa-miR-892c-5p	91.5903	NM_001080414
CCDC88C	hsa-miR-199b-5p	91.0721	NM_001080414
CCDC88C	hsa-miR-199a-5p	91.0721	NM_001080414
CCDC88C	hsa-miR-922	90.9285	NM_001080414
CCDC88C	hsa-miR-29b-2-5p	90.8211	NM_001080414
CCDC88C	hsa-miR-6826-5p	90.0844	NM_001080414
CCDC88C	hsa-miR-3180-5p	88.7462	NM_001080414
CCDC88C	hsa-miR-6748-3p	88.5865	NM_001080414
CCDC88C	hsa-miR-3121-3p	86.5344	NM_001080414
CCDC88C	hsa-miR-1825	85.5824	NM_001080414
CCDC88C	hsa-miR-424-5p	84.147	NM_001080414
CCDC88C	hsa-miR-497-5p	84.147	NM_001080414
CCDC88C	hsa-miR-15a-5p	83.7154	NM_001080414
CCDC88C	hsa-miR-16-5p	83.7154	NM_001080414
CCDC88C	hsa-miR-15b-5p	83.7154	NM_001080414
CCDC88C	hsa-miR-195-5p	83.7154	NM_001080414
CCDC88C	hsa-miR-6838-5p	83.7154	NM_001080414
CCDC88C	hsa-miR-543	83.6342	NM_001080414
CCDC88C	hsa-miR-574-5p	82.2454	NM_001080414

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Motifs and transcription factors (TFs) regulating CCDC88C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC88C	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CCDC88C	hdpi__NRL	NRL (directAnnotation).
CCDC88C	transfac_pro__M07310	SP5 (directAnnotation).
CCDC88C	cisbp__M07938	E2F1 (directAnnotation).
CCDC88C	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
CCDC88C	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CCDC88C	transfac_pro__M04817	ZBTB33 (directAnnotation).
CCDC88C	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CCDC88C	tfdimers__MD00483	ZBTB14 (directAnnotation).
CCDC88C	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CCDC88C	transfac_pro__M02089	E2F3 (directAnnotation).
CCDC88C	transfac_pro__M12697	ZNF142 (directAnnotation).
CCDC88C	transfac_pro__M00716	ZBTB14 (directAnnotation).
CCDC88C	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CCDC88C	transfac_pro__M03806	ZBTB7C (directAnnotation).
CCDC88C	transfac_pro__M01253	CNOT3 (directAnnotation).
CCDC88C	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CCDC88C	transfac_pro__M01783	SP2 (directAnnotation).
CCDC88C	transfac_pro__M04916	TAF1 (directAnnotation).
CCDC88C	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CCDC88C	hdpi__HTATIP2	HTATIP2 (directAnnotation).
CCDC88C	jaspar__MA1650.1	ZBTB14 (directAnnotation).
CCDC88C	hdpi__HIP2	UBE2K (directAnnotation).
CCDC88C	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
CCDC88C	hdpi__ZNF304	ZNF304 (directAnnotation).
CCDC88C	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CCDC88C	cisbp__M08228	PAX5 (directAnnotation).
CCDC88C	transfac_pro__M00938	E2F1 (directAnnotation).
CCDC88C	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
CCDC88C	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC88C	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
CCDC88C	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CCDC88C	cisbp__M00788	ZFY (inferredBy_Orthology).
CCDC88C	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
CCDC88C	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
CCDC88C	transfac_pro__M03846	SMAD5 (directAnnotation).
CCDC88C	metacluster_45.4	E2F2 (directAnnotation).
CCDC88C	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC88C	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CCDC88C	metacluster_7.13	ZFX (directAnnotation).
CCDC88C	hdpi__FEZF2	FEZF2 (directAnnotation).
CCDC88C	cisbp__M00343	PAX6 (directAnnotation).
CCDC88C	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC88C	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CCDC88C	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
CCDC88C	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CCDC88C	transfac_pro__M01199	TRIM28 (directAnnotation).
CCDC88C	transfac_pro__M12694	ZFP14 (directAnnotation).
CCDC88C	cisbp__M00341	PAX6 (directAnnotation).
CCDC88C	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."