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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC68

Summary for CCDC68

Gene information	Gene symbol	CCDC68
	Ensembl ID	ENSG00000166510
	Entrez ID	80323
	Gene name	coiled-coil domain containing 68
	Synonyms	SE57-1
	Gene type	protein_coding
	UniProtAcc	Q9H2F9

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Dataset with differentially expressed gene: CCDC68

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.450065	0.00e+00

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Expression of CCDC68 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC68

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC68

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC68	hsa-miR-590-3p	99.071	NM_025214
CCDC68	hsa-miR-629-3p	92.6866	NM_025214
CCDC68	hsa-miR-3681-5p	92.5104	NM_025214
CCDC68	hsa-miR-4303	91.9738	NM_001143829
CCDC68	hsa-miR-6849-5p	91.1951	NM_025214
CCDC68	hsa-miR-380-3p	90.3986	NM_025214
CCDC68	hsa-miR-377-3p	89.8372	NM_025214
CCDC68	hsa-miR-4271	88.9352	NM_025214
CCDC68	hsa-miR-3910	88.7944	NM_025214
CCDC68	hsa-miR-4775	88.3179	NM_025214
CCDC68	hsa-miR-6780b-5p	87.7299	NM_025214
CCDC68	hsa-miR-4725-3p	87.7299	NM_025214
CCDC68	hsa-miR-335-3p	87.5962	NM_025214
CCDC68	hsa-miR-485-3p	85.5658	NM_025214
CCDC68	hsa-miR-539-3p	85.5658	NM_025214
CCDC68	hsa-miR-550a-5p	85.173	NM_025214
CCDC68	hsa-miR-550a-3-5p	85.173	NM_025214
CCDC68	hsa-miR-1271-3p	85.173	NM_025214
CCDC68	hsa-miR-340-5p	85.0803	NM_001143829
CCDC68	hsa-miR-4776-3p	84.5728	NM_025214
CCDC68	hsa-miR-202-3p	83.8754	NM_025214
CCDC68	hsa-miR-548bb-3p	82.7996	NM_025214
CCDC68	hsa-miR-548d-3p	82.7996	NM_025214
CCDC68	hsa-miR-548ac	82.7996	NM_025214
CCDC68	hsa-miR-548z	82.7996	NM_025214
CCDC68	hsa-miR-548h-3p	82.7996	NM_025214
CCDC68	hsa-miR-1261	82.761	NM_025214
CCDC68	hsa-miR-6760-3p	82.3785	NM_025214
CCDC68	hsa-miR-4724-3p	81.5936	NM_025214
CCDC68	hsa-miR-4704-5p	80.7581	NM_025214
CCDC68	hsa-miR-6886-3p	80.6472	NM_025214

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Motifs and transcription factors (TFs) regulating CCDC68

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC68	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CCDC68	tfdimers__MD00038	TFAP2C (directAnnotation).
CCDC68	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CCDC68	metacluster_7.13	ZFX (directAnnotation).
CCDC68	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CCDC68	cisbp__M00968	MTF2 (directAnnotation).
CCDC68	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CCDC68	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CCDC68	metacluster_198.3	ZFP64 (directAnnotation).
CCDC68	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CCDC68	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CCDC68	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CCDC68	cisbp__M00788	ZFY (inferredBy_Orthology).
CCDC68	metacluster_175.1	ZNF283 (directAnnotation).
CCDC68	hdpi__ZNF304	ZNF304 (directAnnotation).
CCDC68	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CCDC68	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CCDC68	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CCDC68	transfac_pro__M01199	TRIM28 (directAnnotation).
CCDC68	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CCDC68	metacluster_151.2	ZNF23 (directAnnotation).
CCDC68	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC68	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CCDC68	transfac_pro__M03806	ZBTB7C (directAnnotation).
CCDC68	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."