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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC34

Summary for CCDC34

Gene information	Gene symbol	CCDC34
	Ensembl ID	ENSG00000109881
	Entrez ID	91057
	Gene name	coiled-coil domain containing 34
	Synonyms	L15\|NY-REN-41\|RAMA3
	Gene type	protein_coding
	UniProtAcc	Q96HJ3

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Dataset with differentially expressed gene: CCDC34

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.75434	1.98e-17
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.815313	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.252874	3.27e-07
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.969261	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.440702	5.04e-38
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.480415	3.75e-27
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.271822	8.63e-12
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.320832	1.36e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.270826	1.83e-04

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Expression of CCDC34 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC34

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC34

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC34	hsa-miR-4282	99.5303	NM_080654
CCDC34	hsa-miR-374a-5p	97.8407	NM_080654
CCDC34	hsa-miR-374b-5p	97.5934	NM_080654
CCDC34	hsa-miR-5579-3p	93.1465	NM_080654
CCDC34	hsa-miR-3671	92.1672	NM_080654
CCDC34	hsa-miR-12136	91.0786	NM_030771
CCDC34	hsa-miR-7159-5p	91.0165	NM_080654
CCDC34	hsa-miR-29a-5p	90.6831	NM_030771
CCDC34	hsa-miR-4328	90.571	NM_080654
CCDC34	hsa-miR-7850-5p	90.3531	NM_080654
CCDC34	hsa-miR-4428	89.8408	NM_080654
CCDC34	hsa-miR-548ac	89.3218	NM_030771
CCDC34	hsa-miR-548d-3p	89.3218	NM_030771
CCDC34	hsa-miR-548h-3p	89.3218	NM_030771
CCDC34	hsa-miR-548bb-3p	89.3218	NM_030771
CCDC34	hsa-miR-548z	89.3218	NM_030771
CCDC34	hsa-miR-130b-5p	88.6051	NM_080654
CCDC34	hsa-miR-4762-3p	88.5056	NM_030771
CCDC34	hsa-miR-10522-5p	88.4452	NM_080654
CCDC34	hsa-miR-1248	86.086	NM_080654
CCDC34	hsa-miR-3692-3p	85.7309	NM_080654
CCDC34	hsa-miR-212-3p	84.629	NM_080654
CCDC34	hsa-miR-132-3p	84.629	NM_080654
CCDC34	hsa-miR-4724-5p	83.5834	NM_080654
CCDC34	hsa-miR-890	82.9581	NM_080654
CCDC34	hsa-miR-488-5p	82.4735	NM_030771
CCDC34	hsa-miR-302f	81.5093	NM_030771
CCDC34	hsa-miR-196a-1-3p	81.3032	NM_080654
CCDC34	hsa-miR-548aw	80.7139	NM_030771
CCDC34	hsa-miR-1249-5p	80.5176	NM_080654
CCDC34	hsa-miR-6797-5p	80.5176	NM_080654
CCDC34	hsa-miR-7853-5p	80.0325	NM_030771
CCDC34	hsa-miR-105-5p	80.0325	NM_030771

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Motifs and transcription factors (TFs) regulating CCDC34

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC34	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CCDC34	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
CCDC34	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CCDC34	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CCDC34	jaspar__MA1122.1	TFDP1 (directAnnotation).
CCDC34	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CCDC34	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CCDC34	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CCDC34	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CCDC34	transfac_pro__M04918	EGR1 (directAnnotation).
CCDC34	hdpi__FLI1	FLI1 (directAnnotation).
CCDC34	jaspar__MA0748.2	YY2 (directAnnotation).
CCDC34	metacluster_182.10	ZFX (directAnnotation).
CCDC34	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
CCDC34	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."