Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC198

Summary for CCDC198

Gene information	Gene symbol	CCDC198
	Ensembl ID	ENSG00000100557
	Entrez ID	55195
	Gene name	coiled-coil domain containing 198
	Synonyms	C14orf105\|FLJ10650
	Gene type	protein_coding
	UniProtAcc	Q9NVL8

Top

Dataset with differentially expressed gene: CCDC198

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.503483	0.00e+00

Top

Expression of CCDC198 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CCDC198

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CCDC198

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC198	hsa-miR-1304-5p	92.7391	NM_001283057
CCDC198	hsa-miR-4255	92.5087	NM_001283057
CCDC198	hsa-miR-140-3p	88.3134	NM_001283057
CCDC198	hsa-miR-6867-5p	87.6068	NM_001283060
CCDC198	hsa-miR-4432	87.2986	NM_001283057
CCDC198	hsa-miR-4790-5p	86.9303	NM_001283057
CCDC198	hsa-miR-519e-5p	86.1672	NM_001283060
CCDC198	hsa-miR-9-3p	85.3032	NM_001283057
CCDC198	hsa-miR-2681-5p	84.9013	NM_001283057
CCDC198	hsa-miR-4760-3p	84.4586	NM_001283057
CCDC198	hsa-miR-3059-5p	83.6338	NM_001283057
CCDC198	hsa-miR-3074-3p	82.1319	NM_001283057
CCDC198	hsa-miR-515-5p	81.9296	NM_001283060
CCDC198	hsa-miR-506-3p	81.5575	NM_001283057
CCDC198	hsa-miR-124-3p	81.5575	NM_001283057
CCDC198	hsa-miR-6893-3p	81.0829	NM_001283057
CCDC198	hsa-miR-370-3p	81.0829	NM_001283057

Page: 1

Top

Motifs and transcription factors (TFs) regulating CCDC198

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."