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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC191

Summary for CCDC191

Gene information	Gene symbol	CCDC191
	Ensembl ID	ENSG00000163617
	Entrez ID	57577
	Gene name	coiled-coil domain containing 191
	Synonyms	KIAA1407
	Gene type	protein_coding
	UniProtAcc	Q8NCU4

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Dataset with differentially expressed gene: CCDC191

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.708677	1.70e-03
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.362195	0.00e+00

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Expression of CCDC191 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC191

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC191

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC191	hsa-miR-223-5p	94.3665	NM_020817
CCDC191	hsa-miR-297	92.6615	NM_020817
CCDC191	hsa-miR-5571-5p	92.1946	NM_020817
CCDC191	hsa-miR-4652-3p	88.7069	NM_020817
CCDC191	hsa-miR-7515	86.5542	NM_020817
CCDC191	hsa-miR-6748-3p	85.7635	NM_020817
CCDC191	hsa-miR-3123	83.0906	NM_020817
CCDC191	hsa-miR-4291	82.8639	NM_020817
CCDC191	hsa-miR-376b-3p	82.4716	NM_020817
CCDC191	hsa-miR-376a-3p	82.4716	NM_020817
CCDC191	hsa-miR-6867-5p	81.7511	NM_020817
CCDC191	hsa-miR-140-3p	81.4915	NM_020817
CCDC191	hsa-miR-3154	81.2803	NM_020817
CCDC191	hsa-miR-374a-5p	81.1023	NM_020817
CCDC191	hsa-miR-4452	80.6681	NM_020817
CCDC191	hsa-miR-374b-5p	80.3236	NM_020817

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Motifs and transcription factors (TFs) regulating CCDC191

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC191	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CCDC191	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
CCDC191	kznf__ZNF26_Imbeault2017_OM_MEME	ZNF26 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."