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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCAR1

Summary for CCAR1

Gene information	Gene symbol	CCAR1
	Ensembl ID	ENSG00000060339
	Entrez ID	55749
	Gene name	cell division cycle and apoptosis regulator 1
	Synonyms	CARP-1\|CARP1\|FLJ10590
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CCAR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.586872	2.92e-05
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.520819	4.08e-41
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.278725	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.297039	5.34e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.448202	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.256023	8.77e-38

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Expression of CCAR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCAR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCAR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCAR1	hsa-miR-5582-3p	98.8146	NM_001282959
CCAR1	hsa-miR-548aw	98.6913	NM_001282959
CCAR1	hsa-miR-7158-3p	98.4567	NM_001282960
CCAR1	hsa-miR-548g-3p	96.8752	NM_001282960
CCAR1	hsa-miR-548ar-3p	95.5593	NM_001282959
CCAR1	hsa-miR-6830-3p	93.9674	NM_001282959
CCAR1	hsa-miR-1468-3p	93.424	NM_001282960
CCAR1	hsa-miR-548e-3p	93.2281	NM_001282959
CCAR1	hsa-miR-548a-3p	93.2281	NM_001282959
CCAR1	hsa-miR-548bc	93.2281	NM_001282959
CCAR1	hsa-miR-548az-3p	93.2281	NM_001282959
CCAR1	hsa-miR-548f-3p	93.2281	NM_001282959
CCAR1	hsa-miR-489-3p	92.9033	NM_001282959
CCAR1	hsa-miR-7112-3p	91.6387	NM_001282959
CCAR1	hsa-miR-607	91.5364	NM_001282959
CCAR1	hsa-miR-433-3p	90.3151	NM_001282959
CCAR1	hsa-miR-106a-3p	89.0129	NM_001282960
CCAR1	hsa-miR-4314	87.8098	NM_001282960
CCAR1	hsa-miR-548av-3p	86.8114	NM_001282960
CCAR1	hsa-miR-6083	86.6062	NM_001282960
CCAR1	hsa-miR-6072	86.4655	NM_001282960
CCAR1	hsa-miR-204-3p	85.3337	NM_001282960
CCAR1	hsa-miR-4646-5p	85.3337	NM_001282960
CCAR1	hsa-miR-5000-3p	84.9526	NM_001282960
CCAR1	hsa-miR-3136-5p	84.8254	NM_001282960
CCAR1	hsa-miR-4439	84.8254	NM_001282960
CCAR1	hsa-miR-548f-5p	82.8205	NM_001282960
CCAR1	hsa-miR-548g-5p	82.8205	NM_001282960
CCAR1	hsa-miR-548x-5p	82.8205	NM_001282960
CCAR1	hsa-miR-548aj-5p	82.8205	NM_001282960
CCAR1	hsa-miR-6891-3p	82.4111	NM_001282960
CCAR1	hsa-miR-664b-3p	81.9085	NM_001282960
CCAR1	hsa-miR-579-3p	81.9085	NM_001282960
CCAR1	hsa-miR-888-3p	81.7477	NM_001282959
CCAR1	hsa-miR-3613-3p	81.6768	NM_001282959
CCAR1	hsa-miR-5089-5p	81.6117	NM_001282960
CCAR1	hsa-miR-543	80.7649	NM_001282959

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Motifs and transcription factors (TFs) regulating CCAR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCAR1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CCAR1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CCAR1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
CCAR1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CCAR1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CCAR1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CCAR1	transfac_pro__M04950	EGR1 (directAnnotation).
CCAR1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CCAR1	transfac_pro__M00652	NRF1 (directAnnotation).
CCAR1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CCAR1	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CCAR1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CCAR1	jaspar__MA0748.2	YY2 (directAnnotation).
CCAR1	transfac_pro__M05544	BCL11A (directAnnotation).
CCAR1	taipale_cyt_meth__ZBTB2_NTTTCCGGTAMN_eDBD_meth_repr	ZBTB2 (directAnnotation).
CCAR1	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
CCAR1	jaspar__MA0502.2	NFYB (directAnnotation).
CCAR1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
CCAR1	transfac_pro__M06071	ZNF814 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."