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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CBR4

Summary for CBR4

Gene information	Gene symbol	CBR4
	Ensembl ID	ENSG00000145439
	Entrez ID	84869
	Gene name	carbonyl reductase 4
	Synonyms	FLJ14431\|SDR45C1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CBR4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.325446	2.72e-25

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Expression of CBR4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CBR4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CBR4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CBR4	hsa-miR-1468-3p	94.592	NM_032783
CBR4	hsa-miR-3619-5p	92.3547	NM_032783
CBR4	hsa-miR-7154-5p	91.2521	NM_032783
CBR4	hsa-miR-548aw	90.0607	NM_032783
CBR4	hsa-miR-761	89.308	NM_032783
CBR4	hsa-miR-214-3p	89.308	NM_032783
CBR4	hsa-miR-5589-3p	86.2455	NM_032783
CBR4	hsa-miR-12123	85.4503	NM_032783
CBR4	hsa-miR-4427	85.4496	NM_032783
CBR4	hsa-miR-6852-3p	84.9877	NM_032783
CBR4	hsa-miR-514b-5p	83.8626	NM_032783
CBR4	hsa-miR-513c-5p	83.8626	NM_032783
CBR4	hsa-miR-219a-2-3p	83.7398	NM_032783
CBR4	hsa-miR-181a-2-3p	83.1564	NM_032783
CBR4	hsa-miR-548f-5p	83.1357	NM_032783
CBR4	hsa-miR-548x-5p	83.1357	NM_032783
CBR4	hsa-miR-548aj-5p	83.1357	NM_032783
CBR4	hsa-miR-548g-5p	83.1357	NM_032783
CBR4	hsa-miR-340-5p	81.562	NM_032783
CBR4	hsa-miR-4677-5p	81.1874	NM_032783
CBR4	hsa-miR-548l	80.7165	NM_032783
CBR4	hsa-miR-3163	80.6231	NM_032783

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Motifs and transcription factors (TFs) regulating CBR4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CBR4	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."