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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAV2

Summary for CAV2

Gene information	Gene symbol	CAV2
	Ensembl ID	ENSG00000105971
	Entrez ID	858
	Gene name	caveolin 2
	Synonyms	CAV
	Gene type	protein_coding
	UniProtAcc	P51636

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Dataset with differentially expressed gene: CAV2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.268445	4.28e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-2.92111	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.252724	2.42e-14
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.32222	1.20e-17
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.549992	8.81e-34
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.32027	3.21e-14
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.423569	1.14e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.17995	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.381943	0.00e+00

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Expression of CAV2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAV2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CAV2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CAV2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAV2	hsa-miR-4729	97.5701	NM_001206747
CAV2	hsa-miR-510-3p	97.4789	NM_001206747
CAV2	hsa-miR-549a-5p	95.597	NM_198212
CAV2	hsa-miR-95-5p	95.2029	NM_198212
CAV2	hsa-miR-4528	94.6703	NM_198212
CAV2	hsa-miR-153-5p	94.0377	NM_198212
CAV2	hsa-miR-4698	92.9714	NM_198212
CAV2	hsa-miR-520d-5p	92.9587	NM_001233
CAV2	hsa-miR-524-5p	92.9587	NM_001233
CAV2	hsa-miR-29a-3p	92.935	NM_001206747
CAV2	hsa-miR-29b-3p	92.935	NM_001206747
CAV2	hsa-miR-29c-3p	92.935	NM_001206747
CAV2	hsa-miR-548m	92.8806	NM_198212
CAV2	hsa-miR-4282	92.835	NM_001206747
CAV2	hsa-miR-32-3p	92.6642	NM_001206747
CAV2	hsa-let-7f-2-3p	92.3083	NM_001206747
CAV2	hsa-miR-1185-2-3p	92.3083	NM_001206747
CAV2	hsa-miR-1185-1-3p	92.3083	NM_001206747
CAV2	hsa-miR-6124	91.4243	NM_198212
CAV2	hsa-miR-488-3p	91.4183	NM_001206747
CAV2	hsa-miR-664b-3p	91.0071	NM_198212
CAV2	hsa-miR-579-3p	91.0071	NM_198212
CAV2	hsa-miR-33a-3p	90.5835	NM_198212
CAV2	hsa-miR-3140-3p	89.5443	NM_198212
CAV2	hsa-miR-144-3p	89.5328	NM_001233
CAV2	hsa-miR-374b-5p	89.4295	NM_198212
CAV2	hsa-miR-374a-5p	89.3366	NM_198212
CAV2	hsa-miR-8081	88.791	NM_198212
CAV2	hsa-miR-548c-3p	88.728	NM_001206747
CAV2	hsa-miR-4503	87.8926	NM_198212
CAV2	hsa-miR-656-3p	87.6484	NM_001206747
CAV2	hsa-miR-216a-5p	86.7599	NM_198212
CAV2	hsa-miR-4773	86.7376	NM_198212
CAV2	hsa-miR-338-5p	86.6957	NM_001206747
CAV2	hsa-miR-627-5p	86.501	NM_198212
CAV2	hsa-miR-4703-3p	86.3932	NM_198212
CAV2	hsa-miR-606	84.2656	NM_198212
CAV2	hsa-miR-4307	83.6814	NM_198212
CAV2	hsa-miR-150-3p	83.5791	NM_198212
CAV2	hsa-miR-5571-5p	82.7985	NM_198212
CAV2	hsa-miR-5699-5p	82.1378	NM_198212
CAV2	hsa-miR-589-3p	81.3393	NM_198212
CAV2	hsa-miR-6871-3p	80.6245	NM_001206747
CAV2	hsa-miR-603	80.478	NM_198212
CAV2	hsa-miR-570-3p	80.2936	NM_001206747
CAV2	hsa-miR-5582-3p	80.1549	NM_198212
CAV2	hsa-miR-4803	80.0981	NM_198212
CAV2	hsa-miR-6504-3p	80.0692	NM_001233
CAV2	hsa-miR-5590-3p	80.0152	NM_001206747
CAV2	hsa-miR-142-5p	80.0152	NM_001206747

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Motifs and transcription factors (TFs) regulating CAV2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAV2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
CAV2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CAV2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CAV2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CAV2	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
CAV2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
CAV2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CAV2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CAV2	transfac_pro__M04866	HDAC2 (directAnnotation).
CAV2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CAV2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
CAV2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CAV2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CAV2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CAV2	jaspar__MA1548.1	PLAGL2 (directAnnotation).
CAV2	transfac_pro__M06005	ZNF232 (directAnnotation).
CAV2	transfac_pro__M06135	ZNF28 (directAnnotation).
CAV2	transfac_pro__M06614	ZNF594 (directAnnotation).
CAV2	transfac_public__M00491	PATZ1 (directAnnotation).
CAV2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CAV2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
CAV2	transfac_pro__M04918	EGR1 (directAnnotation).
CAV2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CAV2	transfac_pro__M04826	EP300 (directAnnotation).
CAV2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
CAV2	jaspar__MA0748.2	YY2 (directAnnotation).
CAV2	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CAV2	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
CAV2	metacluster_182.10	ZFX (directAnnotation).
CAV2	transfac_pro__M00492	STAT1 (directAnnotation).
CAV2	swissregulon__hs__ELF2	ELF2 (directAnnotation).
CAV2	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
CAV2	jaspar__MA1708.1	ETV7 (directAnnotation).
CAV2	hdpi__ELF2	ELF2 (directAnnotation).
CAV2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
CAV2	metacluster_183.4	ETS1 (inferredBy_Orthology).
CAV2	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
CAV2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
CAV2	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."