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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CASP8AP2

Summary for CASP8AP2

Gene information	Gene symbol	CASP8AP2
	Ensembl ID	ENSG00000288475
	Entrez ID	9994
	Gene name	caspase 8 associated protein 2
	Synonyms	CED-4\|FLASH\|FLJ11208\|KIAA1315\|RIP25
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CASP8AP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.318399	3.52e-21

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Expression of CASP8AP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CASP8AP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CASP8AP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CASP8AP2	hsa-miR-1185-1-3p	99.9773	NM_001137667
CASP8AP2	hsa-let-7f-2-3p	99.9773	NM_001137667
CASP8AP2	hsa-miR-1185-2-3p	99.9773	NM_001137667
CASP8AP2	hsa-let-7b-3p	99.9719	NM_001137667
CASP8AP2	hsa-miR-98-3p	99.9719	NM_001137667
CASP8AP2	hsa-let-7f-1-3p	99.9719	NM_001137667
CASP8AP2	hsa-let-7a-3p	99.9719	NM_001137667
CASP8AP2	hsa-miR-4789-5p	99.9319	NM_001137667
CASP8AP2	hsa-miR-1323	99.8287	NM_001137667
CASP8AP2	hsa-miR-548o-3p	99.7417	NM_001137667
CASP8AP2	hsa-miR-7-1-3p	94.7429	NM_001137667
CASP8AP2	hsa-miR-7-2-3p	94.7429	NM_001137667
CASP8AP2	hsa-miR-10527-5p	94.6731	NM_001137667
CASP8AP2	hsa-miR-5580-3p	93.2737	NM_001137667
CASP8AP2	hsa-miR-548e-5p	92.4462	NM_001137667
CASP8AP2	hsa-miR-323a-3p	90.4555	NM_001137667
CASP8AP2	hsa-miR-217-3p	84.1161	NM_001137667
CASP8AP2	hsa-miR-7158-3p	83.8707	NM_001137667
CASP8AP2	hsa-miR-8075	83.3009	NM_001137667
CASP8AP2	hsa-miR-6840-3p	81.9868	NM_001137667
CASP8AP2	hsa-miR-4695-5p	81.8371	NM_001137667

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Motifs and transcription factors (TFs) regulating CASP8AP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CASP8AP2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CASP8AP2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CASP8AP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CASP8AP2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."