Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CASP8

Summary for CASP8

Gene information	Gene symbol	CASP8
	Ensembl ID	ENSG00000064012
	Entrez ID	841
	Gene name	caspase 8
	Synonyms	Casp-8\|FLICE\|MACH\|MCH5
	Gene type	protein_coding
	UniProtAcc	Q14790

Top

Dataset with differentially expressed gene: CASP8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.285931	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.304839	2.72e-07
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.265034	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.381433	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD4+ T cells	-0.31377	6.78e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	CD8+ T cells	-0.26286	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.412266	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.480981	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.328184	8.05e-04

Top

Expression of CASP8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CASP8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CASP8	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating CASP8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CASP8	hsa-miR-548e-5p	98.5997	NM_033356
CASP8	hsa-miR-6508-5p	95.5286	NM_033356
CASP8	hsa-miR-8067	94.9694	NM_033356
CASP8	hsa-miR-548at-5p	94.5476	NM_033356
CASP8	hsa-miR-6815-3p	89.2773	NM_033358
CASP8	hsa-miR-5011-5p	88.2655	NM_033356
CASP8	hsa-miR-4715-3p	81.2085	NM_033358
CASP8	hsa-miR-3613-3p	81.1844	NM_001080124

Page: 1

Top

Motifs and transcription factors (TFs) regulating CASP8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CASP8	transfac_pro__M09720	RELA (inferredBy_Orthology).
CASP8	transfac_pro__M06584	ZNF606 (directAnnotation).
CASP8	transfac_pro__M05636	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
CASP8	transfac_pro__M06075	ZNF197 (directAnnotation).
CASP8	tfdimers__MD00074	SOX4; YY2 (directAnnotation).
CASP8	metacluster_27.8	SOX10; SOX9 (directAnnotation).
CASP8	transfac_pro__M06523	ZNF527 (directAnnotation).
CASP8	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CASP8	metacluster_79.18	ZNF81; ZNF81 (directAnnotation).
CASP8	metacluster_155.33	ZNF16; ZNF816 (directAnnotation).
CASP8	transfac_pro__M04858	THAP1 (directAnnotation).
CASP8	transfac_pro__M05488	ZSCAN5B (directAnnotation).
CASP8	transfac_pro__M05610	YY2 (directAnnotation).
CASP8	metacluster_44.19	NKX3-1 (inferredBy_Orthology).
CASP8	metacluster_141.9	TAF1; YY1; YY1 (directAnnotation).
CASP8	jaspar__MA1994.1	NKX2-1 (inferredBy_Orthology).
CASP8	transfac_pro__M06008	ZBTB40 (directAnnotation).
CASP8	metacluster_92.3	ZNF354A (directAnnotation). ZNF354B (inferredBy_Orthology).
CASP8	transfac_pro__M06138	ZNF23 (directAnnotation).
CASP8	kznf__ZKSCAN2_Imbeault2017_OM_RCADE	ZKSCAN2 (directAnnotation).
CASP8	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
CASP8	jaspar__MA1125.1	ZNF384 (directAnnotation).
CASP8	tfdimers__MD00076	HNF1A; HNF1B; PPARG (directAnnotation).
CASP8	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
CASP8	tfdimers__MD00066	ELF1 (directAnnotation).
CASP8	jaspar__MA1483.2	ELF2 (directAnnotation).
CASP8	transfac_pro__M00655	ETV4 (directAnnotation).
CASP8	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CASP8	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
CASP8	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
CASP8	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
CASP8	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
CASP8	jaspar__MA1935.1	FOXI1 (directAnnotation).
CASP8	tfdimers__MD00045	STAT6; ZNF354C (directAnnotation).
CASP8	jaspar__MA0136.3	ELF5 (inferredBy_Orthology).
CASP8	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
CASP8	transfac_pro__M06462	ZNF441 (directAnnotation).
CASP8	homer__YCTTTGTTCC_Sox4	SOX4 (inferredBy_Orthology).
CASP8	jaspar__MA1952.1	FOXJ2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CASP8	"AN-9"	DB05103	small molecule
CASP8	"Bardoxolone"	DB12651	small molecule
CASP8	"Bryostatin 1"	DB11752	small molecule
CASP8	"Oleandrin"	DB12843	small molecule
CASP8	"Trichostatin A"	DB04297	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."