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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAPZA2

Summary for CAPZA2

Gene information	Gene symbol	CAPZA2
	Ensembl ID	ENSG00000198898
	Entrez ID	830
	Gene name	capping actin protein of muscle Z-line subunit alpha 2
	Synonyms	CAPPA2\|CAPZ
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CAPZA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.25464	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.338438	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.290601	6.56e-04
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.272441	2.14e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.295661	9.18e-10
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Mono/Macro	-0.305395	1.46e-21
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.450775	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.256004	3.49e-27
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.296533	4.86e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.324382	6.13e-16

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Expression of CAPZA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAPZA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAPZA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAPZA2	hsa-miR-4312	99.3354	NM_006136
CAPZA2	hsa-miR-582-5p	97.987	NM_006136
CAPZA2	hsa-miR-6504-3p	97.4024	NM_006136
CAPZA2	hsa-miR-10399-5p	97.4024	NM_006136
CAPZA2	hsa-miR-5011-5p	97.3232	NM_006136
CAPZA2	hsa-miR-3163	96.9441	NM_006136
CAPZA2	hsa-miR-1322	96.9101	NM_006136
CAPZA2	hsa-miR-7844-5p	96.6354	NM_006136
CAPZA2	hsa-miR-8062	95.148	NM_006136
CAPZA2	hsa-miR-498-5p	94.5194	NM_006136
CAPZA2	hsa-miR-4474-3p	94.3169	NM_006136
CAPZA2	hsa-miR-106a-3p	92.5814	NM_006136
CAPZA2	hsa-miR-1284	92.5809	NM_006136
CAPZA2	hsa-miR-4524a-5p	92.5672	NM_006136
CAPZA2	hsa-miR-4524b-5p	92.5672	NM_006136
CAPZA2	hsa-miR-211-3p	92.0983	NM_006136
CAPZA2	hsa-miR-374a-5p	91.7925	NM_006136
CAPZA2	hsa-miR-374b-5p	90.5456	NM_006136
CAPZA2	hsa-miR-190a-3p	90.5327	NM_006136
CAPZA2	hsa-miR-5003-3p	90.4302	NM_006136
CAPZA2	hsa-miR-372-5p	89.9687	NM_006136
CAPZA2	hsa-miR-708-3p	89.3983	NM_006136
CAPZA2	hsa-miR-3117-5p	88.6831	NM_006136
CAPZA2	hsa-miR-493-5p	88.0357	NM_006136
CAPZA2	hsa-miR-576-5p	87.6239	NM_006136
CAPZA2	hsa-miR-552-5p	87.3274	NM_006136
CAPZA2	hsa-miR-216a-5p	87.0248	NM_006136
CAPZA2	hsa-miR-369-3p	86.9451	NM_006136
CAPZA2	hsa-miR-6773-3p	86.7669	NM_006136
CAPZA2	hsa-miR-548t-5p	85.8616	NM_006136
CAPZA2	hsa-miR-548az-5p	85.8616	NM_006136
CAPZA2	hsa-miR-3680-3p	85.4398	NM_006136
CAPZA2	hsa-miR-4452	84.4792	NM_006136
CAPZA2	hsa-miR-195-5p	84.2876	NM_006136
CAPZA2	hsa-miR-15a-5p	84.2876	NM_006136
CAPZA2	hsa-miR-15b-5p	84.2876	NM_006136
CAPZA2	hsa-miR-16-5p	84.2876	NM_006136
CAPZA2	hsa-miR-888-5p	83.9876	NM_006136
CAPZA2	hsa-miR-586	82.8426	NM_006136
CAPZA2	hsa-miR-4694-3p	82.665	NM_006136
CAPZA2	hsa-miR-1272	82.3488	NM_006136
CAPZA2	hsa-miR-450b-5p	81.683	NM_006136
CAPZA2	hsa-miR-374c-5p	81.0474	NM_006136
CAPZA2	hsa-miR-655-3p	81.0474	NM_006136
CAPZA2	hsa-miR-4698	81.0053	NM_006136
CAPZA2	hsa-miR-183-3p	80.9597	NM_006136
CAPZA2	hsa-miR-6838-5p	80.657	NM_006136
CAPZA2	hsa-miR-497-5p	80.657	NM_006136
CAPZA2	hsa-miR-424-5p	80.657	NM_006136
CAPZA2	hsa-miR-4762-3p	80.414	NM_006136

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Motifs and transcription factors (TFs) regulating CAPZA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAPZA2	transfac_pro__M05481	ZNF202 (directAnnotation).
CAPZA2	transfac_pro__M05846	ZNF689 (directAnnotation).
CAPZA2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CAPZA2	transfac_pro__M05298	OVOL3 (directAnnotation).
CAPZA2	metacluster_33.5	MTF1 (inferredBy_Orthology).
CAPZA2	metacluster_168.1	ZSCAN16 (directAnnotation).
CAPZA2	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
CAPZA2	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
CAPZA2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CAPZA2	transfac_pro__M04950	EGR1 (directAnnotation).
CAPZA2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CAPZA2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
CAPZA2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
CAPZA2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CAPZA2	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
CAPZA2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CAPZA2	transfac_pro__M00652	NRF1 (directAnnotation).
CAPZA2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CAPZA2	transfac_pro__M04866	HDAC2 (directAnnotation).
CAPZA2	jaspar__MA1122.1	TFDP1 (directAnnotation).
CAPZA2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CAPZA2	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
CAPZA2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CAPZA2	jaspar__MA1708.1	ETV7 (directAnnotation).
CAPZA2	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
CAPZA2	hocomoco__HSFY1_HUMAN.H11MO.0.D	HSFY1; HSFY2 (directAnnotation).
CAPZA2	cisbp__M02748	NFATC1 (directAnnotation).
CAPZA2	transfac_pro__M01660	GABPA (directAnnotation).
CAPZA2	tfdimers__MD00217	LTF; MZF1 (directAnnotation).
CAPZA2	transfac_pro__M06786	ZNF646 (directAnnotation).
CAPZA2	tfdimers__MD00586	FOS; FOSB; FOSL1; FOSL2; JUN; JUNB; JUND; PPARG (directAnnotation).
CAPZA2	tfdimers__MD00500	ASCL1; BHLHE40; BHLHE41; HAND1; HAND2; MAX; MITF; MXD1; MXD3; MXD4; MXI1; MYC; MYCN; MYF5; MYF6; MYOD1; MYOG; NHLH1; TAL1; TAL2; TCF12; TCF3; TCF4; TFE3; TFEB; TP53; USF1; USF2 (directAnnotation).
CAPZA2	transfac_pro__M05393	ZBTB6 (inferredBy_Orthology).
CAPZA2	metacluster_175.3	GRHL1; TFCP2; TFCP2; TFCP2; TFCP2; TFCP2; TFCP2; TFCP2L1; TFCP2L1; UBP1; UBP1; ZNF217 (directAnnotation). GRHL1; GRHL2; GRHL3; TFCP2; TFCP2L1; TFCP2L1; TFCP2L1; TFCP2L1; UBP1 (inferredBy_Orthology).
CAPZA2	transfac_pro__M06107	ZNF43 (directAnnotation).
CAPZA2	metacluster_175.2	TFCP2L1; ZNF329; ZNF329 (directAnnotation). TFCP2L1; TFCP2L1 (inferredBy_Orthology).
CAPZA2	tfdimers__MD00215	LEF1; STAT1 (directAnnotation).
CAPZA2	transfac_pro__M06887	HINFP (directAnnotation).
CAPZA2	swissregulon__hs__SPI1	SPI1 (directAnnotation).
CAPZA2	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
CAPZA2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
CAPZA2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
CAPZA2	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
CAPZA2	jaspar__MA0748.2	YY2 (directAnnotation).
CAPZA2	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
CAPZA2	hdpi__EBF1	EBF1 (directAnnotation).
CAPZA2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
CAPZA2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CAPZA2	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
CAPZA2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."