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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CAPNS1

Summary for CAPNS1

Gene information	Gene symbol	CAPNS1
	Ensembl ID	ENSG00000126247
	Entrez ID	826
	Gene name	calpain small subunit 1
	Synonyms	30K\|CANP\|CANPS\|CAPN4\|CDPS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CAPNS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.371263	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.280563	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.336912	3.47e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.41222	2.97e-18
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	-0.270318	1.06e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.366556	3.44e-36
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.265972	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.405896	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.308554	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.379891	0.00e+00

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Expression of CAPNS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAPNS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
CAPNS1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating CAPNS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAPNS1	hsa-miR-6773-5p	84.0277	NM_001302632
CAPNS1	hsa-miR-4455	83.5499	NM_001302632
CAPNS1	hsa-miR-6132	82.9608	NM_001302632
CAPNS1	hsa-miR-6836-5p	82.9608	NM_001302632

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Motifs and transcription factors (TFs) regulating CAPNS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAPNS1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CAPNS1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CAPNS1	jaspar__MA0079.5	SP1 (directAnnotation).
CAPNS1	transfac_pro__M05877	ZNF467 (inferredBy_Orthology).
CAPNS1	homer__TAATCCCN_Pitx1	PITX1 (inferredBy_Orthology).
CAPNS1	taipale_tf_pairs__FLI1_CEBPD_RNCGGANNTTGCGCAAN_CAP	CEBPD; FLI1 (directAnnotation).
CAPNS1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
CAPNS1	transfac_pro__M05483	ZBTB1 (directAnnotation).
CAPNS1	taipale_tf_pairs__ERF_DLX2_RSCGGAANNNNNYMATTA_CAP_repr_1	DLX2; ERF (directAnnotation).
CAPNS1	transfac_pro__M04856	BATF (directAnnotation).
CAPNS1	transfac_pro__M06314	ZNF239 (directAnnotation).
CAPNS1	transfac_pro__M06949	EVX2 (directAnnotation).
CAPNS1	tfdimers__MD00156	CRX (directAnnotation).
CAPNS1	cisbp__M02408	NR2E1 (inferredBy_Orthology).
CAPNS1	taipale_tf_pairs__ERF_DLX2_RSCGGAANNNNNYMATTA_CAP_repr_2	DLX2; ERF (directAnnotation).
CAPNS1	jaspar__MA1125.1	ZNF384 (directAnnotation).
CAPNS1	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
CAPNS1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
CAPNS1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CAPNS1	metacluster_55.5	ZNF541 (directAnnotation).
CAPNS1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
CAPNS1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
CAPNS1	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CAPNS1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
CAPNS1	taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAP	CEBPD; ERF (directAnnotation).
CAPNS1	transfac_pro__M05560	AEBP2 (directAnnotation).
CAPNS1	taipale_tf_pairs__CUX1_SOX15_NATCRATNNNNNNNAACAATRS_CAP_repr	CUX1; SOX15 (directAnnotation).
CAPNS1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
CAPNS1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CAPNS1	"PD150606"	DB02570	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."