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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAND1

Summary for CAND1

Gene information	Gene symbol	CAND1
	Ensembl ID	ENSG00000111530
	Entrez ID	55832
	Gene name	cullin associated and neddylation dissociated 1
	Synonyms	DKFZp434M1414\|KIAA0829\|TIP120\|TIP120A
	Gene type	protein_coding
	UniProtAcc	Q86VP6

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Dataset with differentially expressed gene: CAND1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.299094	1.49e-13
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.42318	0.00e+00

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Expression of CAND1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAND1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAND1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAND1	hsa-miR-548aw	99.4992	NM_018448
CAND1	hsa-miR-1468-3p	97.4227	NM_018448
CAND1	hsa-miR-548x-5p	97.161	NM_018448
CAND1	hsa-miR-548aj-5p	97.161	NM_018448
CAND1	hsa-miR-548g-5p	97.161	NM_018448
CAND1	hsa-miR-548f-5p	97.161	NM_018448
CAND1	hsa-miR-5587-5p	96.8485	NM_018448
CAND1	hsa-miR-5688	96.4848	NM_018448
CAND1	hsa-miR-495-3p	96.3303	NM_018448
CAND1	hsa-miR-607	95.6619	NM_018448
CAND1	hsa-miR-1252-5p	95.0551	NM_018448
CAND1	hsa-miR-570-3p	94.3652	NM_018448
CAND1	hsa-miR-152-3p	93.8054	NM_018448
CAND1	hsa-miR-148b-3p	93.8054	NM_018448
CAND1	hsa-miR-148a-3p	93.8054	NM_018448
CAND1	hsa-miR-140-3p	93.5082	NM_018448
CAND1	hsa-miR-30c-5p	92.8852	NM_018448
CAND1	hsa-miR-30b-5p	92.8852	NM_018448
CAND1	hsa-miR-30e-5p	92.8852	NM_018448
CAND1	hsa-miR-30d-5p	92.8852	NM_018448
CAND1	hsa-miR-30a-5p	92.8852	NM_018448
CAND1	hsa-miR-4276	92.5457	NM_018448
CAND1	hsa-miR-1252-3p	91.5948	NM_018448
CAND1	hsa-miR-1323	91.5634	NM_018448
CAND1	hsa-miR-548c-3p	91.5277	NM_018448
CAND1	hsa-miR-6839-5p	91.4148	NM_018448
CAND1	hsa-miR-378j	90.938	NM_018448
CAND1	hsa-miR-500a-5p	90.7109	NM_018448
CAND1	hsa-miR-548o-3p	89.7005	NM_018448
CAND1	hsa-miR-381-3p	89.6789	NM_018448
CAND1	hsa-miR-300	89.6789	NM_018448
CAND1	hsa-miR-4495	89.5949	NM_018448
CAND1	hsa-miR-302c-5p	89.5755	NM_018448
CAND1	hsa-miR-196a-1-3p	89.4013	NM_018448
CAND1	hsa-miR-4328	89.1628	NM_018448
CAND1	hsa-miR-6776-3p	88.4044	NM_018448
CAND1	hsa-miR-19b-3p	88.3889	NM_018448
CAND1	hsa-miR-19a-3p	88.3889	NM_018448
CAND1	hsa-miR-3143	88.2608	NM_018448
CAND1	hsa-miR-9985	87.8252	NM_018448
CAND1	hsa-miR-27b-3p	87.8252	NM_018448
CAND1	hsa-miR-27a-3p	87.8252	NM_018448
CAND1	hsa-miR-4282	86.9967	NM_018448
CAND1	hsa-miR-377-3p	86.5113	NM_018448
CAND1	hsa-miR-582-5p	86.408	NM_018448
CAND1	hsa-miR-3688-3p	86.1888	NM_018448
CAND1	hsa-miR-548v	85.406	NM_018448
CAND1	hsa-miR-649	85.2166	NM_018448
CAND1	hsa-miR-590-3p	84.5346	NM_018448
CAND1	hsa-miR-4668-3p	83.5345	NM_018448

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Motifs and transcription factors (TFs) regulating CAND1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAND1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
CAND1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
CAND1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CAND1	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
CAND1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CAND1	metacluster_3.14	WT1; WT1 (directAnnotation).
CAND1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CAND1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CAND1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CAND1	jaspar__MA0502.2	NFYB (directAnnotation).
CAND1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CAND1	metacluster_7.13	ZFX (directAnnotation).
CAND1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
CAND1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CAND1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CAND1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CAND1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CAND1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CAND1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CAND1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CAND1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."