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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAMK2N1

Summary for CAMK2N1

Gene information	Gene symbol	CAMK2N1
	Ensembl ID	ENSG00000162545
	Entrez ID	55450
	Gene name	calcium/calmodulin dependent protein kinase II inhibitor 1
	Synonyms	CaMKIINalpha
	Gene type	protein_coding
	UniProtAcc	Q7Z7J9

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Dataset with differentially expressed gene: CAMK2N1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-3.31919	8.02e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.415415	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.32391	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.887428	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-1.02035	0.00e+00

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Expression of CAMK2N1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAMK2N1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAMK2N1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAMK2N1	hsa-miR-6867-5p	99.999	NM_018584
CAMK2N1	hsa-miR-6719-3p	99.2915	NM_018584
CAMK2N1	hsa-miR-5193	97.5654	NM_018584
CAMK2N1	hsa-miR-450b-5p	95.1678	NM_018584
CAMK2N1	hsa-miR-9983-3p	95.0209	NM_018584
CAMK2N1	hsa-miR-129-5p	94.7898	NM_018584
CAMK2N1	hsa-miR-3658	90.8364	NM_018584
CAMK2N1	hsa-miR-511-3p	90.7957	NM_018584
CAMK2N1	hsa-miR-3123	90.2277	NM_018584
CAMK2N1	hsa-miR-493-5p	90.1338	NM_018584
CAMK2N1	hsa-miR-183-3p	88.8976	NM_018584
CAMK2N1	hsa-miR-627-3p	87.6767	NM_018584
CAMK2N1	hsa-miR-192-3p	87.6356	NM_018584
CAMK2N1	hsa-miR-30c-5p	86.45	NM_018584
CAMK2N1	hsa-miR-30d-5p	86.45	NM_018584
CAMK2N1	hsa-miR-30e-5p	86.45	NM_018584
CAMK2N1	hsa-miR-30b-5p	86.45	NM_018584
CAMK2N1	hsa-miR-30a-5p	86.45	NM_018584
CAMK2N1	hsa-miR-96-5p	84.9231	NM_018584
CAMK2N1	hsa-miR-4684-3p	84.7308	NM_018584
CAMK2N1	hsa-miR-548aw	83.1388	NM_018584
CAMK2N1	hsa-miR-888-3p	82.8801	NM_018584
CAMK2N1	hsa-miR-495-5p	82.7762	NM_018584
CAMK2N1	hsa-miR-3160-5p	82.323	NM_018584
CAMK2N1	hsa-miR-4311	81.4701	NM_018584
CAMK2N1	hsa-let-7i-3p	81.3515	NM_018584
CAMK2N1	hsa-miR-8070	81.0472	NM_018584
CAMK2N1	hsa-miR-6883-3p	80.8233	NM_018584
CAMK2N1	hsa-miR-6779-3p	80.4822	NM_018584
CAMK2N1	hsa-miR-4531	80.4751	NM_018584

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Motifs and transcription factors (TFs) regulating CAMK2N1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAMK2N1	transfac_pro__M03813	POU3F3 (directAnnotation).
CAMK2N1	hocomoco__MNX1_HUMAN.H11MO.0.D	MNX1 (directAnnotation).
CAMK2N1	transfac_pro__M06074	ZNF732 (directAnnotation).
CAMK2N1	transfac_pro__M06213	ZNF267 (directAnnotation).
CAMK2N1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
CAMK2N1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
CAMK2N1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CAMK2N1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CAMK2N1	transfac_pro__M06032	ZNF727 (directAnnotation).
CAMK2N1	cisbp__M00808	MYPOP (inferredBy_Orthology).
CAMK2N1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
CAMK2N1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CAMK2N1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."