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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CAMK2B

Summary for CAMK2B

Gene information	Gene symbol	CAMK2B
	Ensembl ID	ENSG00000058404
	Entrez ID	816
	Gene name	calcium/calmodulin dependent protein kinase II beta
	Synonyms	CAM2\|CAMK2\|CAMKB\|CaMKIIbeta
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CAMK2B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	1.11639	0.00e+00

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Expression of CAMK2B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAMK2B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAMK2B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAMK2B	hsa-miR-361-3p	99.1921	NM_172080
CAMK2B	hsa-miR-24-3p	92.8012	NM_001293170
CAMK2B	hsa-miR-548f-5p	92.3274	NM_001220
CAMK2B	hsa-miR-548g-5p	92.3274	NM_001220
CAMK2B	hsa-miR-548x-5p	92.3274	NM_001220
CAMK2B	hsa-miR-548aj-5p	92.3274	NM_001220
CAMK2B	hsa-miR-589-3p	90.1372	NM_001293170
CAMK2B	hsa-miR-545-3p	89.8712	NM_001293170
CAMK2B	hsa-miR-6507-5p	88.6851	NM_001293170
CAMK2B	hsa-miR-939-3p	87.6322	NM_172080
CAMK2B	hsa-miR-512-5p	87.3895	NM_001293170
CAMK2B	hsa-miR-4455	86.9648	NM_172080
CAMK2B	hsa-miR-3166	85.759	NM_172080
CAMK2B	hsa-miR-4749-3p	83.1854	NM_172080
CAMK2B	hsa-miR-653-5p	81.6641	NM_001220
CAMK2B	hsa-miR-4740-3p	80.8062	NM_001293170
CAMK2B	hsa-miR-184	80.2268	NM_001293170
CAMK2B	hsa-miR-10a-5p	80.079	NM_001220
CAMK2B	hsa-miR-10b-5p	80.079	NM_001220

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Motifs and transcription factors (TFs) regulating CAMK2B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAMK2B	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CAMK2B	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CAMK2B	transfac_public__M00491	PATZ1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CAMK2B	"Fostamatinib"	DB12010	small molecule
CAMK2B	"[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitri	DB07168	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."