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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CALD1

Summary for CALD1

Gene information	Gene symbol	CALD1
	Ensembl ID	ENSG00000122786
	Entrez ID	800
	Gene name	caldesmon 1
	Synonyms	CDM\|H-CAD\|h-CD\|L-CAD
	Gene type	protein_coding
	UniProtAcc	Q05682

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Dataset with differentially expressed gene: CALD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.617911	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.266845	1.24e-09
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.816998	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.581901	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.994035	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.33085	1.34e-23
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.543552	8.19e-39
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.27821	5.86e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.370558	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.396597	9.95e-18
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.79435	0.00e+00

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Expression of CALD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CALD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CALD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CALD1	hsa-miR-3163	97.2884	NM_004342
CALD1	hsa-miR-509-5p	97.2126	NM_004342
CALD1	hsa-miR-509-3-5p	97.2126	NM_004342
CALD1	hsa-miR-4418	96.8615	NM_004342
CALD1	hsa-miR-6505-3p	96.1683	NM_004342
CALD1	hsa-miR-3182	95.9023	NM_004342
CALD1	hsa-miR-24-2-5p	95.5709	NM_004342
CALD1	hsa-miR-24-1-5p	95.5709	NM_004342
CALD1	hsa-miR-493-5p	93.8907	NM_004342
CALD1	hsa-miR-8067	93.8043	NM_004342
CALD1	hsa-miR-4803	93.4196	NM_004342
CALD1	hsa-miR-106b-5p	93.327	NM_004342
CALD1	hsa-miR-20a-5p	93.327	NM_004342
CALD1	hsa-miR-6508-5p	92.9018	NM_004342
CALD1	hsa-miR-936	92.0642	NM_004342
CALD1	hsa-miR-222-5p	91.7134	NM_004342
CALD1	hsa-miR-6513-3p	91.4187	NM_004342
CALD1	hsa-miR-5094	90.8168	NM_004342
CALD1	hsa-miR-380-3p	90.7739	NM_004342
CALD1	hsa-miR-106a-5p	90.4892	NM_004342
CALD1	hsa-miR-20b-5p	90.4892	NM_004342
CALD1	hsa-miR-93-5p	90.4892	NM_004342
CALD1	hsa-miR-526b-3p	90.4892	NM_004342
CALD1	hsa-miR-17-5p	90.4892	NM_004342
CALD1	hsa-miR-519d-3p	90.4892	NM_004342
CALD1	hsa-miR-548c-3p	90.2501	NM_004342
CALD1	hsa-miR-6505-5p	90.1818	NM_004342
CALD1	hsa-miR-1914-5p	89.9858	NM_004342
CALD1	hsa-miR-4679	89.7422	NM_004342
CALD1	hsa-miR-9985	87.9949	NM_004342
CALD1	hsa-miR-27a-3p	87.9949	NM_004342
CALD1	hsa-miR-513a-5p	87.9949	NM_004342
CALD1	hsa-miR-27b-3p	87.9949	NM_004342
CALD1	hsa-miR-6875-3p	87.6913	NM_004342
CALD1	hsa-miR-5003-3p	87.2875	NM_004342
CALD1	hsa-miR-6506-5p	87.1482	NM_004342
CALD1	hsa-miR-619-5p	87.1482	NM_004342
CALD1	hsa-miR-153-5p	86.6026	NM_004342
CALD1	hsa-miR-4742-3p	86.5911	NM_004342
CALD1	hsa-miR-32-3p	85.96	NM_004342
CALD1	hsa-miR-4772-5p	84.3616	NM_004342
CALD1	hsa-miR-1250-3p	83.815	NM_004342
CALD1	hsa-miR-12113	81.9784	NM_004342
CALD1	hsa-miR-6867-5p	81.5782	NM_004342
CALD1	hsa-miR-4282	80.7515	NM_004342
CALD1	hsa-miR-6839-3p	80.1029	NM_004342

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Motifs and transcription factors (TFs) regulating CALD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CALD1	transfac_pro__M05479	ZNF580 (directAnnotation).
CALD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CALD1	cisbp__M08198	ELF1 (directAnnotation).
CALD1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
CALD1	transfac_pro__M05894	ZNF565 (directAnnotation).
CALD1	transfac_pro__M07301	NFATC4 (directAnnotation).
CALD1	transfac_pro__M07608	ILF2; NFAT5; NFATC1; NFATC2; NFATC4 (directAnnotation).
CALD1	metacluster_22.11	NFE2 (directAnnotation).
CALD1	metacluster_31.3	ZSCAN20; ZSCAN29 (directAnnotation).
CALD1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
CALD1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
CALD1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
CALD1	metacluster_22.36	BACH2 (directAnnotation).
CALD1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
CALD1	metacluster_22.17	NFE2 (directAnnotation).
CALD1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
CALD1	transfac_pro__M03555	ILF2; NFATC2 (directAnnotation).
CALD1	transfac_pro__M06304	ZNF260 (directAnnotation).
CALD1	hdpi__RAB18	RAB18 (directAnnotation).
CALD1	transfac_pro__M05574	ZFP92 (directAnnotation).
CALD1	metacluster_44.7	NKX3-2 (directAnnotation).
CALD1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CALD1	jaspar__MA0502.2	NFYB (directAnnotation).
CALD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CALD1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
CALD1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
CALD1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
CALD1	hdpi__TP73	TP73 (directAnnotation).
CALD1	cisbp__M02645	ETS1 (directAnnotation).
CALD1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
CALD1	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
CALD1	jaspar__MA1932.1	HOXB13 (directAnnotation).
CALD1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CALD1	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
CALD1	transfac_pro__M00492	STAT1 (directAnnotation).
CALD1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CALD1	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CALD1	nitta__nau_TAGGTG20NTGT_KG_NNGTCAGCTGACNN_m1_c3	MYF5; MYF6; MYOD1; MYOG (inferredBy_Orthology).
CALD1	transfac_pro__M05956	BCL11B (directAnnotation).
CALD1	metacluster_22.28	BACH1 (directAnnotation).
CALD1	transfac_pro__M06111	ZNF254 (directAnnotation).
CALD1	transfac_pro__M06084	ZNF208 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."