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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CALCOCO1

Summary for CALCOCO1

Gene information	Gene symbol	CALCOCO1
	Ensembl ID	ENSG00000012822
	Entrez ID	57658
	Gene name	calcium binding and coiled-coil domain 1
	Synonyms	calphoglin\|Cocoa\|KIAA1536
	Gene type	protein_coding
	UniProtAcc	Q9P1Z2

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Dataset with differentially expressed gene: CALCOCO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.73581	1.78e-06

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Expression of CALCOCO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CALCOCO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CALCOCO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CALCOCO1	hsa-miR-6867-5p	99.9862	NM_020898
CALCOCO1	hsa-miR-574-5p	99.8465	NM_001143682
CALCOCO1	hsa-miR-1277-5p	93.4019	NM_020898
CALCOCO1	hsa-miR-5187-5p	92.7675	NM_020898
CALCOCO1	hsa-miR-124-3p	91.1279	NM_020898
CALCOCO1	hsa-miR-506-3p	91.1279	NM_020898
CALCOCO1	hsa-miR-605-3p	88.7577	NM_020898
CALCOCO1	hsa-miR-5582-5p	88.6369	NM_020898
CALCOCO1	hsa-miR-4260	88.4121	NM_020898
CALCOCO1	hsa-miR-487a-3p	88.272	NM_020898
CALCOCO1	hsa-miR-154-3p	88.272	NM_020898
CALCOCO1	hsa-miR-3145-5p	85.2819	NM_001143682
CALCOCO1	hsa-miR-137-3p	85.1306	NM_020898
CALCOCO1	hsa-miR-3150b-3p	83.7921	NM_020898
CALCOCO1	hsa-miR-589-5p	83.7019	NM_001143682
CALCOCO1	hsa-miR-6790-5p	82.8552	NM_001143682
CALCOCO1	hsa-miR-6728-5p	82.0326	NM_001143682
CALCOCO1	hsa-miR-4719	81.2339	NM_020898
CALCOCO1	hsa-miR-486-3p	80.1051	NM_020898
CALCOCO1	hsa-miR-1275	80.0331	NM_001143682

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Motifs and transcription factors (TFs) regulating CALCOCO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CALCOCO1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CALCOCO1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."