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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CADM3

Summary for CADM3

Gene information	Gene symbol	CADM3
	Ensembl ID	ENSG00000162706
	Entrez ID	57863
	Gene name	cell adhesion molecule 3
	Synonyms	BIgR\|FLJ10698\|IGSF4B\|Necl-1\|NECL1\|SynCAM3\|TSLL1
	Gene type	protein_coding
	UniProtAcc	Q8N126

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Dataset with differentially expressed gene: CADM3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.470872	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.570312	0.00e+00

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Expression of CADM3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CADM3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CADM3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CADM3	hsa-miR-8485	96.5672	NM_001127173
CADM3	hsa-miR-6721-5p	95.5248	NM_001127173
CADM3	hsa-miR-7106-5p	94.9981	NM_001127173
CADM3	hsa-miR-135b-5p	94.1365	NM_001127173
CADM3	hsa-miR-135a-5p	94.1365	NM_001127173
CADM3	hsa-miR-6762-3p	93.5399	NM_001127173
CADM3	hsa-miR-5583-3p	92.0059	NM_001127173
CADM3	hsa-miR-488-5p	91.8504	NM_001127173
CADM3	hsa-miR-6815-3p	90.9958	NM_001127173
CADM3	hsa-miR-7113-5p	90.3066	NM_001127173
CADM3	hsa-miR-4446-3p	87.4553	NM_001127173
CADM3	hsa-miR-6077	86.9694	NM_001127173
CADM3	hsa-miR-7-5p	85.5531	NM_001127173
CADM3	hsa-miR-340-5p	85.5011	NM_001127173
CADM3	hsa-miR-3184-5p	85.2954	NM_001127173
CADM3	hsa-miR-423-5p	85.2954	NM_001127173
CADM3	hsa-miR-4668-5p	84.6539	NM_001127173
CADM3	hsa-miR-8085	83.8383	NM_001127173
CADM3	hsa-miR-6731-5p	83.8383	NM_001127173
CADM3	hsa-miR-4726-3p	83.4266	NM_001127173
CADM3	hsa-miR-6513-5p	83.3101	NM_001127173
CADM3	hsa-miR-6882-5p	83.2129	NM_001127173
CADM3	hsa-miR-4685-5p	82.8233	NM_001127173
CADM3	hsa-miR-4749-3p	82.3072	NM_001127173
CADM3	hsa-miR-7160-5p	81.9236	NM_001127173
CADM3	hsa-miR-6837-5p	81.8291	NM_001127173
CADM3	hsa-miR-647	80.605	NM_001127173
CADM3	hsa-miR-4492	80.4049	NM_001127173
CADM3	hsa-miR-1913	80.3335	NM_001127173

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Motifs and transcription factors (TFs) regulating CADM3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CADM3	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
CADM3	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
CADM3	transfac_pro__M06117	ZNF23 (directAnnotation).
CADM3	swissregulon__hs__EZH2	EZH2 (directAnnotation).
CADM3	jaspar__MA0079.5	SP1 (directAnnotation).
CADM3	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).

Page: 1

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."