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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CACNB3

Summary for CACNB3

Gene information	Gene symbol	CACNB3
	Ensembl ID	ENSG00000167535
	Entrez ID	784
	Gene name	calcium voltage-gated channel auxiliary subunit beta 3
	Synonyms	CACNLB3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CACNB3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.415552	0.00e+00

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Expression of CACNB3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CACNB3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CACNB3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CACNB3	hsa-miR-449a	91.9042	NM_000725
CACNB3	hsa-miR-34a-5p	91.9042	NM_000725
CACNB3	hsa-miR-6722-3p	90.4343	NM_000725
CACNB3	hsa-miR-619-3p	90.269	NM_000725
CACNB3	hsa-miR-1909-3p	90.0145	NM_000725
CACNB3	hsa-miR-4319	89.488	NM_000725
CACNB3	hsa-miR-550a-3-5p	89.153	NM_000725
CACNB3	hsa-miR-1271-3p	89.153	NM_000725
CACNB3	hsa-miR-550a-5p	89.153	NM_000725
CACNB3	hsa-miR-449b-5p	88.9172	NM_000725
CACNB3	hsa-miR-34c-5p	88.9172	NM_000725
CACNB3	hsa-miR-125b-5p	86.2202	NM_000725
CACNB3	hsa-miR-125a-5p	86.2202	NM_000725
CACNB3	hsa-miR-515-5p	83.6673	NM_000725
CACNB3	hsa-miR-519e-5p	83.6673	NM_000725
CACNB3	hsa-miR-6734-3p	83.458	NM_000725
CACNB3	hsa-miR-6805-3p	82.9742	NM_000725
CACNB3	hsa-miR-5691	82.9742	NM_000725
CACNB3	hsa-miR-370-5p	82.9061	NM_000725
CACNB3	hsa-miR-1207-5p	82.4578	NM_000725
CACNB3	hsa-miR-6132	81.2149	NM_000725
CACNB3	hsa-miR-6836-5p	81.2149	NM_000725
CACNB3	hsa-miR-4763-3p	80.5782	NM_000725

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Motifs and transcription factors (TFs) regulating CACNB3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CACNB3	tfdimers__MD00151	CHURC1 (directAnnotation).
CACNB3	transfac_pro__M01714	KLF15 (directAnnotation).
CACNB3	transfac_pro__M02281	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CACNB3	"Dronedarone"	DB04855	small molecule
CACNB3	"Mibefradil"	DB01388	small molecule
CACNB3	"Nimodipine"	DB00393	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."