Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: CACNA2D1

Summary for CACNA2D1

Gene information	Gene symbol	CACNA2D1
	Ensembl ID	ENSG00000153956
	Entrez ID	781
	Gene name	calcium voltage-gated channel auxiliary subunit alpha2delta 1
	Synonyms	alpha2delta-1\|CACNA2\|CACNL2A\|LINC01112\|lncRNA-N3\|MHS3
	Gene type	protein_coding
	UniProtAcc	P54289

Top

Dataset with differentially expressed gene: CACNA2D1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.92131	1.46e-03

Top

Expression of CACNA2D1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CACNA2D1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CACNA2D1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CACNA2D1	hsa-miR-370-5p	99.7782	NM_000722
CACNA2D1	hsa-miR-452-5p	99.1566	NM_000722
CACNA2D1	hsa-miR-892c-3p	99.0718	NM_000722
CACNA2D1	hsa-miR-4676-3p	99.0718	NM_000722
CACNA2D1	hsa-miR-4422	99.0323	NM_000722
CACNA2D1	hsa-miR-5003-5p	98.566	NM_000722
CACNA2D1	hsa-miR-513b-5p	98.2085	NM_000722
CACNA2D1	hsa-miR-3915	98.1918	NM_000722
CACNA2D1	hsa-miR-548e-5p	98.0353	NM_000722
CACNA2D1	hsa-miR-29a-5p	97.6689	NM_000722
CACNA2D1	hsa-miR-12129	97.1207	NM_000722
CACNA2D1	hsa-miR-3613-3p	97.0022	NM_000722
CACNA2D1	hsa-miR-410-5p	96.5545	NM_000722
CACNA2D1	hsa-miR-1252-3p	96.5172	NM_000722
CACNA2D1	hsa-miR-507	96.139	NM_000722
CACNA2D1	hsa-miR-802	95.7605	NM_000722
CACNA2D1	hsa-miR-3925-5p	95.5876	NM_000722
CACNA2D1	hsa-miR-7150	95.3396	NM_000722
CACNA2D1	hsa-miR-323b-5p	95.2281	NM_000722
CACNA2D1	hsa-miR-494-5p	95.2281	NM_000722
CACNA2D1	hsa-miR-3928-3p	95.1445	NM_000722
CACNA2D1	hsa-miR-557	95.1016	NM_000722
CACNA2D1	hsa-miR-196a-1-3p	94.8891	NM_000722
CACNA2D1	hsa-miR-2681-5p	94.7725	NM_000722
CACNA2D1	hsa-miR-1207-5p	93.9483	NM_000722
CACNA2D1	hsa-miR-10526-3p	93.8002	NM_000722
CACNA2D1	hsa-miR-590-3p	93.6804	NM_000722
CACNA2D1	hsa-miR-892c-5p	93.6239	NM_000722
CACNA2D1	hsa-miR-340-5p	93.3801	NM_000722
CACNA2D1	hsa-miR-144-3p	93.2372	NM_000722
CACNA2D1	hsa-miR-107	93.0569	NM_000722
CACNA2D1	hsa-miR-103a-3p	93.0569	NM_000722
CACNA2D1	hsa-miR-4314	92.9675	NM_000722
CACNA2D1	hsa-miR-466	92.33	NM_000722
CACNA2D1	hsa-miR-1287-5p	92.2943	NM_000722
CACNA2D1	hsa-miR-4763-3p	92.0317	NM_000722
CACNA2D1	hsa-miR-605-3p	91.854	NM_000722
CACNA2D1	hsa-miR-548at-5p	91.1639	NM_000722
CACNA2D1	hsa-miR-302f	90.4816	NM_000722
CACNA2D1	hsa-miR-182-5p	90.4035	NM_000722
CACNA2D1	hsa-miR-548p	90.2252	NM_000722
CACNA2D1	hsa-miR-15b-5p	89.9483	NM_000722
CACNA2D1	hsa-miR-3910	89.9419	NM_000722
CACNA2D1	hsa-miR-6165	89.8064	NM_000722
CACNA2D1	hsa-miR-218-2-3p	89.7293	NM_000722
CACNA2D1	hsa-miR-3163	89.477	NM_000722
CACNA2D1	hsa-miR-26a-2-3p	89.3766	NM_000722
CACNA2D1	hsa-miR-4729	89.2792	NM_000722
CACNA2D1	hsa-miR-377-3p	89.1727	NM_000722
CACNA2D1	hsa-miR-3680-3p	89.0786	NM_000722

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CACNA2D1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CACNA2D1	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CACNA2D1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CACNA2D1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
CACNA2D1	transfac_pro__M04617	ZBTB7A (directAnnotation).
CACNA2D1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CACNA2D1	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CACNA2D1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CACNA2D1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CACNA2D1	transfac_pro__M07387	ZBTB7A (directAnnotation).
CACNA2D1	transfac_pro__M07436	WT1 (directAnnotation).
CACNA2D1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CACNA2D1	transfac_pro__M00716	ZBTB14 (directAnnotation).
CACNA2D1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CACNA2D1	hdpi__HIP2	UBE2K (directAnnotation).
CACNA2D1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CACNA2D1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CACNA2D1	transfac_pro__M04893	TAF1 (directAnnotation).
CACNA2D1	transfac_pro__M03876	ZBTB33 (directAnnotation).
CACNA2D1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CACNA2D1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CACNA2D1	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CACNA2D1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CACNA2D1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
CACNA2D1	"Cyclandelate"	DB04838	small molecule
CACNA2D1	"Felodipine"	DB01023	small molecule
CACNA2D1	"Gabapentin enacarbil"	DB08872	small molecule
CACNA2D1	"Gabapentin"	DB00996	small molecule
CACNA2D1	"Ibutilide"	DB00308	small molecule
CACNA2D1	"Isradipine"	DB00270	small molecule
CACNA2D1	"Nicardipine"	DB00622	small molecule
CACNA2D1	"Nilvadipine"	DB06712	small molecule
CACNA2D1	"Nisoldipine"	DB00401	small molecule
CACNA2D1	"Nitrendipine"	DB01054	small molecule
CACNA2D1	"Pregabalin"	DB00230	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."