Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAB39

Summary for CAB39

Gene information	Gene symbol	CAB39
	Ensembl ID	ENSG00000135932
	Entrez ID	51719
	Gene name	calcium binding protein 39
	Synonyms	CGI-66\|MO25
	Gene type	protein_coding
	UniProtAcc	Q9Y376

Top

Dataset with differentially expressed gene: CAB39

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.376487	6.95e-29

Top

Expression of CAB39 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CAB39

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CAB39

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAB39	hsa-miR-4310	99.4761	NM_001130849
CAB39	hsa-miR-4728-3p	99.4702	NM_001130849
CAB39	hsa-miR-7157-5p	99.4008	NM_001130849
CAB39	hsa-miR-203a-3p	99.3596	NM_001130849
CAB39	hsa-miR-3662	98.7382	NM_001130850
CAB39	hsa-miR-3120-3p	97.473	NM_001130849
CAB39	hsa-miR-3646	96.6906	NM_001130849
CAB39	hsa-miR-4326	96.5795	NM_001130849
CAB39	hsa-miR-4753-5p	96.064	NM_001130849
CAB39	hsa-miR-1250-3p	95.9011	NM_001130849
CAB39	hsa-miR-34a-3p	95.5897	NM_001130849
CAB39	hsa-miR-515-5p	95.0285	NM_001130850
CAB39	hsa-miR-519e-5p	95.0285	NM_001130850
CAB39	hsa-miR-519d-5p	94.6502	NM_001130850
CAB39	hsa-miR-23a-3p	94.2968	NM_001130850
CAB39	hsa-miR-23b-3p	94.2968	NM_001130850
CAB39	hsa-miR-23c	94.2968	NM_001130850
CAB39	hsa-miR-3617-3p	93.2727	NM_001130849
CAB39	hsa-miR-4275	92.9377	NM_001130849
CAB39	hsa-miR-497-3p	92.7301	NM_001130849
CAB39	hsa-miR-4517	92.402	NM_001130850
CAB39	hsa-miR-103a-3p	92.226	NM_001130849
CAB39	hsa-miR-107	92.226	NM_001130849
CAB39	hsa-miR-551b-5p	91.8019	NM_001130849
CAB39	hsa-miR-4718	91.3915	NM_001130850
CAB39	hsa-miR-4436b-5p	91.0593	NM_001130849
CAB39	hsa-miR-6508-5p	90.7324	NM_001130849
CAB39	hsa-miR-5002-3p	90.7133	NM_001130849
CAB39	hsa-miR-8067	90.2023	NM_001130849
CAB39	hsa-miR-302c-5p	89.9353	NM_001130850
CAB39	hsa-miR-29a-5p	89.6911	NM_001130850
CAB39	hsa-miR-200b-3p	89.6349	NM_001130849
CAB39	hsa-miR-200c-3p	89.6349	NM_001130849
CAB39	hsa-miR-429	89.6349	NM_001130849
CAB39	hsa-miR-425-5p	89.5199	NM_001130849
CAB39	hsa-miR-6882-5p	89.3231	NM_001130850
CAB39	hsa-miR-19b-3p	88.2473	NM_001130849
CAB39	hsa-miR-19a-3p	88.2473	NM_001130849
CAB39	hsa-miR-548aw	88.2133	NM_001130849
CAB39	hsa-miR-6875-3p	88.1756	NM_001130849
CAB39	hsa-miR-7-2-3p	87.9123	NM_001130849
CAB39	hsa-miR-7-1-3p	87.9123	NM_001130849
CAB39	hsa-miR-4495	87.8864	NM_001130850
CAB39	hsa-miR-670-3p	86.9132	NM_001130849
CAB39	hsa-miR-7853-5p	86.5722	NM_001130850
CAB39	hsa-miR-105-5p	86.5722	NM_001130850
CAB39	hsa-miR-4639-5p	86.2749	NM_001130850
CAB39	hsa-miR-190a-3p	86.1753	NM_001130849
CAB39	hsa-miR-7856-5p	86.09	NM_001130850
CAB39	hsa-miR-4680-3p	84.6134	NM_001130849

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CAB39

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAB39	metacluster_135.11	NR2C2 (directAnnotation).
CAB39	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CAB39	tfdimers__MD00038	TFAP2C (directAnnotation).
CAB39	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CAB39	metacluster_7.13	ZFX (directAnnotation).
CAB39	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CAB39	cisbp__M00968	MTF2 (directAnnotation).
CAB39	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CAB39	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CAB39	cisbp__M00341	PAX6 (directAnnotation).
CAB39	metacluster_198.3	ZFP64 (directAnnotation).
CAB39	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CAB39	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CAB39	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CAB39	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CAB39	cisbp__M00788	ZFY (inferredBy_Orthology).
CAB39	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CAB39	metacluster_175.1	ZNF283 (directAnnotation).
CAB39	hdpi__ZNF304	ZNF304 (directAnnotation).
CAB39	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CAB39	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CAB39	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CAB39	transfac_pro__M01199	TRIM28 (directAnnotation).
CAB39	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CAB39	metacluster_151.2	ZNF23 (directAnnotation).
CAB39	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CAB39	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CAB39	transfac_pro__M03806	ZBTB7C (directAnnotation).
CAB39	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."