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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: C2orf88

Summary for C2orf88

Gene information	Gene symbol	C2orf88
	Ensembl ID	ENSG00000187699
	Entrez ID	84281
	Gene name	chromosome 2 open reading frame 88
	Synonyms	MGC13057\|smAKAP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: C2orf88

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.275401	1.93e-21
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	0.331087	3.44e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.266274	2.46e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.279014	2.69e-24

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Expression of C2orf88 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to C2orf88

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating C2orf88

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C2orf88	hsa-miR-3714	97.4976	NM_001042519
C2orf88	hsa-miR-10397-5p	94.8646	NM_001042519
C2orf88	hsa-miR-592	92.1228	NM_001042519
C2orf88	hsa-miR-218-5p	90.7007	NM_001042519
C2orf88	hsa-miR-1226-5p	90.2325	NM_001042519
C2orf88	hsa-miR-578	90.1809	NM_001042519
C2orf88	hsa-miR-3148	89.4272	NM_001042519
C2orf88	hsa-miR-4652-3p	89.0689	NM_001042519
C2orf88	hsa-miR-3671	89.0441	NM_001042519
C2orf88	hsa-miR-8084	88.852	NM_001042519
C2orf88	hsa-miR-12123	88.1245	NM_001042519
C2orf88	hsa-miR-4645-3p	87.6427	NM_001042519
C2orf88	hsa-miR-6796-5p	87.5999	NM_001042519
C2orf88	hsa-miR-4677-5p	85.4679	NM_001042519
C2orf88	hsa-miR-599	85.1569	NM_001042519
C2orf88	hsa-miR-3910	84.9388	NM_001042519
C2orf88	hsa-miR-6815-3p	84.8814	NM_001042519
C2orf88	hsa-miR-3529-3p	84.518	NM_001042519
C2orf88	hsa-miR-664b-3p	84.1177	NM_001042519
C2orf88	hsa-miR-579-3p	84.1177	NM_001042519
C2orf88	hsa-miR-4708-5p	83.7215	NM_001042519
C2orf88	hsa-miR-600	83.6179	NM_001042519
C2orf88	hsa-miR-124-3p	83.1997	NM_001042519
C2orf88	hsa-miR-506-3p	83.1997	NM_001042519
C2orf88	hsa-miR-4482-3p	82.9167	NM_001042519
C2orf88	hsa-miR-6885-3p	82.3951	NM_001042519
C2orf88	hsa-miR-3122	82.0457	NM_001042519
C2orf88	hsa-miR-607	81.897	NM_001042519
C2orf88	hsa-miR-3913-5p	81.8186	NM_001042519
C2orf88	hsa-miR-3127-3p	81.7724	NM_001042519
C2orf88	hsa-miR-6756-3p	81.7724	NM_001042519
C2orf88	hsa-miR-5582-3p	81.6767	NM_001042519
C2orf88	hsa-miR-205-3p	81.6459	NM_001042519
C2orf88	hsa-miR-1264	81.1303	NM_001042519
C2orf88	hsa-miR-4423-3p	81.0921	NM_001042519
C2orf88	hsa-miR-6844	80.5936	NM_001042519
C2orf88	hsa-miR-129-5p	80.2114	NM_001042519
C2orf88	hsa-miR-9983-3p	80.103	NM_001042519

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Motifs and transcription factors (TFs) regulating C2orf88

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C2orf88	jaspar__MA1483.2	ELF2 (directAnnotation).
C2orf88	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
C2orf88	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
C2orf88	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
C2orf88	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
C2orf88	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
C2orf88	tfdimers__MD00031	MYB; ZEB1 (directAnnotation).
C2orf88	cisbp__M04023	CREB1 (directAnnotation).
C2orf88	metacluster_173.2	ATF3; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; BATF3; CREB3; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L4; XBP1; XBP1; XBP1; XBP1 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM (inferredBy_Orthology).
C2orf88	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
C2orf88	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
C2orf88	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
C2orf88	jaspar__MA1125.1	ZNF384 (directAnnotation).
C2orf88	metacluster_178.5	PAX3; ZNF337; ZNF337 (directAnnotation). PAX3 (inferredBy_Orthology).
C2orf88	transfac_pro__M01298	MECP2 (directAnnotation).
C2orf88	transfac_pro__M05798	ZNF517 (directAnnotation).
C2orf88	transfac_pro__M04706	RELA (directAnnotation).
C2orf88	transfac_pro__M05550	SNAPC4 (inferredBy_Orthology).
C2orf88	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
C2orf88	transfac_pro__M06277	ZNF404 (directAnnotation).
C2orf88	metacluster_63.3	RFX1; RFX2; RFX3; RFX3; RFX3; RFX4; RFX4 (directAnnotation). RFX1; RFX1; RFX2; RFX2; RFX2; RFX3; RFX3; RFX4; RFX4; RFX6; RFX6; RFX6; RFX8; RFX8 (inferredBy_Orthology).
C2orf88	kznf__ZNF778_Imbeault2017_RP_RCADE	ZNF778 (directAnnotation).
C2orf88	metacluster_81.5	ZNF257 (directAnnotation).
C2orf88	metacluster_44.9	NKX2-2 (directAnnotation).
C2orf88	transfac_pro__M06552	ZNF420 (directAnnotation).
C2orf88	metacluster_106.2	ZBTB32 (directAnnotation).
C2orf88	hocomoco__NR1H3_HUMAN.H11MO.1.B	NR1H3 (directAnnotation).
C2orf88	dbtfbs__ZNF157_HEK293_ENCSR564YYW_merged_N1	ZNF157 (directAnnotation).
C2orf88	tfdimers__MD00046	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; SMAD4 (directAnnotation).
C2orf88	metacluster_155.8	ZFP82 (directAnnotation).
C2orf88	transfac_pro__M04785	RAD21 (directAnnotation).
C2orf88	transfac_pro__M06799	ZSCAN12 (directAnnotation).
C2orf88	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
C2orf88	metacluster_111.5	E4F1; E4F1 (directAnnotation).
C2orf88	transfac_pro__M00967	HNF4A; HNF4G; NR2F1; NR2F2 (directAnnotation).
C2orf88	transfac_pro__M01269	NR4A2 (directAnnotation).
C2orf88	transfac_pro__M06730	ZNF624 (directAnnotation).
C2orf88	transfac_pro__M01239	RELA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."