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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: C1QB

Summary for C1QB

Gene information	Gene symbol	C1QB
	Ensembl ID	ENSG00000173369
	Entrez ID	713
	Gene name	complement C1q B chain
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: C1QB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	-0.667212	6.50e-22
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.471622	2.75e-38
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.853832	3.14e-07
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.641316	6.14e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.49626	3.92e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	cDCs	1.20798	8.00e-08

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Expression of C1QB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to C1QB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating C1QB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C1QB	hsa-miR-4709-3p	92.1528	NM_000491
C1QB	hsa-miR-6751-5p	84.7813	NM_000491
C1QB	hsa-miR-3147	82.7645	NM_000491
C1QB	hsa-miR-608	82.1303	NM_000491

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Motifs and transcription factors (TFs) regulating C1QB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C1QB	cisbp__M02743	POU2F2 (directAnnotation).
C1QB	tfdimers__MD00358	FOXA1; HLTF (directAnnotation).
C1QB	metacluster_142.4	POU2AF1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F1; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F3; POU2F3; POU2F3; POU2F3; POU2F3; POU3F1; POU3F2; POU3F3; POU4F1; POU5F1; POU5F1; POU5F1; POU5F1B; POU5F1B; POU5F1B; TBP (directAnnotation). CCDC160; CCDC160; CCDC160; CCDC160; CCDC160; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU2F2; POU3F1; POU3F1; POU3F1; POU3F1; POU3F1; POU3F3; POU3F3; POU3F3; POU3F3; POU3F3; POU3F3; POU3F4; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F1B; POU5F2; POU5F2; POU5F2; POU5F2; POU5F2 (inferredBy_Orthology).
C1QB	transfac_pro__M06265	ZNF791 (directAnnotation).
C1QB	transfac_pro__M06830	ZNF528 (directAnnotation).
C1QB	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
C1QB	transfac_pro__M06253	ZSCAN2 (inferredBy_Orthology).
C1QB	metacluster_70.1	POU5F1 (directAnnotation).
C1QB	tfdimers__MD00036	FOS; FOSB; FOSL1; FOSL2; ILF2; JUN; JUNB; JUND; NFATC2 (directAnnotation).
C1QB	metacluster_70.3	POU3F1 (directAnnotation).
C1QB	transfac_pro__M06611	ZNF560 (directAnnotation).
C1QB	transfac_pro__M05862	ZNF615 (directAnnotation).
C1QB	tfdimers__MD00527	IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
C1QB	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP	ELK1; POU2F1 (directAnnotation).
C1QB	transfac_pro__M06015	ZNF729 (directAnnotation).
C1QB	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
C1QB	transfac_pro__M05422	FOXD4L4 (directAnnotation).
C1QB	tfdimers__MD00027	FOXG1; FOXO1; HLTF (directAnnotation).
C1QB	hdpi__ARNTL	ARNTL (directAnnotation).
C1QB	transfac_pro__M03812	ARNT (directAnnotation).
C1QB	swissregulon__hs__SIX6	SIX6 (directAnnotation).
C1QB	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
C1QB	metacluster_134.6	FOXF1; FOXG1; ZNF74 (directAnnotation). FOXG1 (inferredBy_Orthology).
C1QB	taipale_tf_pairs__TEAD4_TCF3_NCAGGTGNGWATGYN_CAP_repr	TCF3; TEAD4 (directAnnotation).
C1QB	tfdimers__MD00550	PITX3; TEAD1 (directAnnotation).
C1QB	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
C1QB	transfac_pro__M06795	ZNF780B (directAnnotation).
C1QB	transfac_pro__M06153	ZNF83 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
C1QB	"Bevacizumab"	DB00112	biotech
C1QB	"Cetuximab"	DB00002	biotech
C1QB	"Daclizumab"	DB00111	biotech
C1QB	"Palivizumab"	DB00110	biotech
C1QB	"Zinc acetate"	DB14487	small molecule
C1QB	"Zinc chloride"	DB14533	small molecule
C1QB	"Zinc sulfate, unspecified form"	DB14548	small molecule
C1QB	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."