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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: C16orf87

Summary for C16orf87

Gene information	Gene symbol	C16orf87
	Ensembl ID	ENSG00000155330
	Entrez ID	388272
	Gene name	chromosome 16 open reading frame 87
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q6PH81

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Dataset with differentially expressed gene: C16orf87

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.255245	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.25955	4.93e-43

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Expression of C16orf87 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to C16orf87

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating C16orf87

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C16orf87	hsa-miR-6851-3p	94.3071	NM_001001436
C16orf87	hsa-miR-1277-5p	94.1797	NM_001001436
C16orf87	hsa-miR-16-2-3p	93.9957	NM_001001436
C16orf87	hsa-miR-195-3p	93.9957	NM_001001436
C16orf87	hsa-miR-4291	93.7897	NM_001001436
C16orf87	hsa-miR-6875-3p	93.2745	NM_001001436
C16orf87	hsa-miR-192-3p	90.9204	NM_001001436
C16orf87	hsa-miR-4666b	88.3288	NM_001001436
C16orf87	hsa-miR-95-5p	87.3893	NM_001001436
C16orf87	hsa-miR-3680-3p	86.819	NM_001001436
C16orf87	hsa-miR-4526	85.3431	NM_001001436
C16orf87	hsa-miR-3660	85.3431	NM_001001436
C16orf87	hsa-miR-338-3p	85.3002	NM_001001436
C16orf87	hsa-miR-4262	84.9891	NM_001001436
C16orf87	hsa-miR-6083	81.7929	NM_001001436
C16orf87	hsa-miR-802	80.9383	NM_001001436
C16orf87	hsa-miR-5692a	80.3444	NM_001001436
C16orf87	hsa-miR-3646	80.0803	NM_001001436

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Motifs and transcription factors (TFs) regulating C16orf87

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C16orf87	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
C16orf87	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
C16orf87	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
C16orf87	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
C16orf87	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
C16orf87	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
C16orf87	jaspar__MA1721.1	ZNF93 (directAnnotation).
C16orf87	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
C16orf87	metacluster_151.2	ZNF23 (directAnnotation).
C16orf87	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
C16orf87	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
C16orf87	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
C16orf87	transfac_pro__M01199	TRIM28 (directAnnotation).
C16orf87	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
C16orf87	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
C16orf87	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
C16orf87	transfac_pro__M01253	CNOT3 (directAnnotation).
C16orf87	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
C16orf87	transfac_pro__M02913	SP140 (inferredBy_Orthology).
C16orf87	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
C16orf87	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
C16orf87	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
C16orf87	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
C16orf87	cisbp__M00968	MTF2 (directAnnotation).
C16orf87	jaspar__MA0748.2	YY2 (directAnnotation).
C16orf87	metacluster_160.20	JUND; PRDM15 (directAnnotation).
C16orf87	metacluster_7.13	ZFX (directAnnotation).
C16orf87	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
C16orf87	swissregulon__hs__CHD1	CHD1 (directAnnotation).
C16orf87	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
C16orf87	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
C16orf87	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
C16orf87	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
C16orf87	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
C16orf87	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
C16orf87	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
C16orf87	cisbp__M01863	ZNF711 (inferredBy_Orthology).
C16orf87	transfac_pro__M07310	SP5 (directAnnotation).
C16orf87	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
C16orf87	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
C16orf87	transfac_pro__M00938	E2F1 (directAnnotation).
C16orf87	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
C16orf87	transfac_pro__M04893	TAF1 (directAnnotation).
C16orf87	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
C16orf87	transfac_pro__M04817	ZBTB33 (directAnnotation).
C16orf87	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
C16orf87	transfac_pro__M12697	ZNF142 (directAnnotation).
C16orf87	metacluster_175.1	ZNF283 (directAnnotation).
C16orf87	cisbp__M00788	ZFY (inferredBy_Orthology).
C16orf87	tfdimers__MD00364	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."