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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: C15orf40

Summary for C15orf40

Gene information	Gene symbol	C15orf40
	Ensembl ID	ENSG00000169609
	Entrez ID	123207
	Gene name	chromosome 15 open reading frame 40
	Synonyms	MGC29937
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: C15orf40

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.262203	1.49e-16
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.422375	0.00e+00

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Expression of C15orf40 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to C15orf40

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating C15orf40

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C15orf40	hsa-miR-7159-5p	97.7198	NM_144597
C15orf40	hsa-miR-1270	96.9376	NM_001160114
C15orf40	hsa-miR-620	96.9376	NM_001160114
C15orf40	hsa-miR-6827-3p	95.7408	NM_001160113
C15orf40	hsa-miR-340-3p	94.6856	NM_001160113
C15orf40	hsa-miR-4794	94.4041	NM_144597
C15orf40	hsa-miR-3065-5p	94.3703	NM_001160114
C15orf40	hsa-miR-664a-5p	93.5466	NM_144597
C15orf40	hsa-miR-4775	93.2525	NM_144597
C15orf40	hsa-miR-877-5p	91.7902	NM_001160114
C15orf40	hsa-miR-412-3p	91.2453	NM_144597
C15orf40	hsa-miR-616-5p	91.2242	NM_001160114
C15orf40	hsa-miR-371b-5p	91.2242	NM_001160114
C15orf40	hsa-miR-373-5p	91.2242	NM_001160114
C15orf40	hsa-miR-5706	90.71	NM_144597
C15orf40	hsa-miR-4782-5p	90.71	NM_144597
C15orf40	hsa-miR-1305	90.4687	NM_001160114
C15orf40	hsa-miR-7151-3p	90.3811	NM_144597
C15orf40	hsa-miR-511-5p	90.3413	NM_001160116
C15orf40	hsa-miR-3613-3p	89.918	NM_001160113
C15orf40	hsa-miR-6754-3p	89.5492	NM_144597
C15orf40	hsa-miR-4709-3p	89.4605	NM_001160116
C15orf40	hsa-miR-5089-5p	89.3373	NM_144597
C15orf40	hsa-miR-510-3p	88.646	NM_001160114
C15orf40	hsa-let-7g-3p	88.6091	NM_001160116
C15orf40	hsa-let-7a-2-3p	88.6091	NM_001160116
C15orf40	hsa-miR-12131	87.803	NM_144597
C15orf40	hsa-miR-4703-5p	86.7299	NM_144597
C15orf40	hsa-miR-6882-5p	85.8292	NM_001160114
C15orf40	hsa-miR-548c-3p	85.2249	NM_001160114
C15orf40	hsa-miR-3942-5p	85.0892	NM_144597
C15orf40	hsa-miR-4659a-3p	83.9371	NM_144597
C15orf40	hsa-miR-4659b-3p	83.9371	NM_144597
C15orf40	hsa-miR-224-3p	83.7886	NM_001160114
C15orf40	hsa-miR-522-3p	83.7886	NM_001160114
C15orf40	hsa-miR-4531	83.491	NM_144597
C15orf40	hsa-miR-7977	83.2962	NM_144597
C15orf40	hsa-miR-2861	82.4694	NM_001160113
C15orf40	hsa-miR-6773-3p	82.1733	NM_001160114
C15orf40	hsa-miR-6500-3p	81.3042	NM_001160114
C15orf40	hsa-miR-548x-3p	81.0416	NM_144597
C15orf40	hsa-miR-548aj-3p	81.0416	NM_144597
C15orf40	hsa-miR-4766-3p	80.8937	NM_144597
C15orf40	hsa-miR-5011-5p	80.4401	NM_144597
C15orf40	hsa-miR-3198	80.146	NM_144597
C15orf40	hsa-miR-4309	80.146	NM_144597
C15orf40	hsa-miR-4743-3p	80.0983	NM_001160114

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Motifs and transcription factors (TFs) regulating C15orf40

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C15orf40	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
C15orf40	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
C15orf40	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
C15orf40	transfac_pro__M00652	NRF1 (directAnnotation).
C15orf40	hdpi__ETV4	ETV4 (directAnnotation).
C15orf40	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
C15orf40	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
C15orf40	jaspar__MA0502.2	NFYB (directAnnotation).
C15orf40	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
C15orf40	cisbp__M01863	ZNF711 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."