DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: BTRC

Summary for BTRC

Gene informationGene symbol

BTRC

Ensembl ID

ENSG00000166167

Entrez ID

8945

Gene namebeta-transducin repeat containing E3 ubiquitin protein ligase
Synonymsbeta-TrCP1|betaTrCP|bTrCP|bTrCP1|FBXW1A|Fwd1
Gene typeprotein_coding
UniProtAcc

Q9Y297


Top

Dataset with differentially expressed gene: BTRC

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells1.050583.80e-03

Top

Expression of BTRC in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to BTRC

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating BTRC

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
BTRChsa-miR-16-5p99.0366NM_001256856
BTRChsa-miR-195-5p99.0366NM_001256856
BTRChsa-miR-15a-5p99.0366NM_001256856
BTRChsa-miR-15b-5p99.0366NM_001256856
BTRChsa-miR-4524a-5p99.0365NM_001256856
BTRChsa-miR-4524b-5p99.0365NM_001256856
BTRChsa-miR-939-3p98.9725NM_001256856
BTRChsa-miR-424-5p98.6238NM_001256856
BTRChsa-miR-6838-5p98.6238NM_001256856
BTRChsa-miR-497-5p98.6238NM_001256856
BTRChsa-miR-3190-5p97.694NM_001256856
BTRChsa-miR-61297.2559NM_001256856
BTRChsa-miR-5189-5p96.7994NM_001256856
BTRChsa-miR-1285-3p96.7994NM_001256856
BTRChsa-miR-6852-5p96.6849NM_001256856
BTRChsa-miR-686096.6659NM_001256856
BTRChsa-miR-4659b-3p96.2977NM_001256856
BTRChsa-miR-4659a-3p96.2977NM_001256856
BTRChsa-miR-3187-5p95.7669NM_001256856
BTRChsa-miR-6742-3p95.1932NM_001256856
BTRChsa-miR-503-5p94.6444NM_001256856
BTRChsa-miR-330-3p94.6234NM_001256856
BTRChsa-miR-807793.7192NM_001256856
BTRChsa-miR-64692.9327NM_001256856
BTRChsa-miR-382-3p92.2559NM_003939
BTRChsa-miR-10791.6847NM_001256856
BTRChsa-miR-103a-3p91.6847NM_001256856
BTRChsa-miR-445091.5268NM_001256856
BTRChsa-miR-1277-5p91.3842NM_001256856
BTRChsa-miR-397891.0223NM_003939
BTRChsa-miR-199b-5p90.3895NM_003939
BTRChsa-miR-199a-5p90.3895NM_003939
BTRChsa-miR-318289.9779NM_001256856
BTRChsa-miR-317989.7499NM_003939
BTRChsa-miR-397489.7146NM_001256856
BTRChsa-miR-123189.6672NM_001256856
BTRChsa-miR-3925-5p89.5802NM_001256856
BTRChsa-miR-4433b-5p88.3782NM_001256856
BTRChsa-miR-6833-3p87.5875NM_003939
BTRChsa-miR-447086.8738NM_003939
BTRChsa-miR-480386.0607NM_003939
BTRChsa-miR-3191-5p85.9729NM_001256856
BTRChsa-miR-1236-3p85.0029NM_001256856
BTRChsa-miR-3678-3p84.9709NM_003939
BTRChsa-miR-3151-3p84.0497NM_003939
BTRChsa-miR-6736-3p84.0142NM_003939
BTRChsa-miR-7156-3p83.9507NM_001256856
BTRChsa-miR-365783.7066NM_001256856
BTRChsa-miR-3189-5p83.6112NM_003939
BTRChsa-miR-5196-5p83.511NM_003939
Page: 1 2

Top

Motifs and transcription factors (TFs) regulating BTRC

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
BTRCkznf__ZNF594_Schmitges2016_RCADEZNF594 (directAnnotation).
BTRCmetacluster_195.2EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
BTRCtransfac_pro__M04617ZBTB7A (directAnnotation).
BTRCtaipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_methE2F2 (directAnnotation).
BTRCtransfac_pro__M07387ZBTB7A (directAnnotation).
BTRCtransfac_pro__M07436WT1 (directAnnotation).
BTRCswissregulon__hs__CHD1CHD1 (directAnnotation).
BTRChdpi__HIP2UBE2K (directAnnotation).
BTRCtaipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_reprGCM1; SPDEF (directAnnotation).
BTRCmetacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
BTRCtransfac_pro__M03876ZBTB33 (directAnnotation).
BTRCmetacluster_15.2E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BTRCmetacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BTRCkznf__ZNF441_Imbeault2017_RP_RCADEZNF441 (directAnnotation).
BTRCtransfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BTRCmetacluster_3.7SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."