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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BTBD3

Summary for BTBD3

Gene information	Gene symbol	BTBD3
	Ensembl ID	ENSG00000132640
	Entrez ID	22903
	Gene name	BTB domain containing 3
	Synonyms	dJ742J24.1\|KIAA0952
	Gene type	protein_coding
	UniProtAcc	Q9Y2F9

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Dataset with differentially expressed gene: BTBD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.251353	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.403901	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.353637	1.26e-44

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Expression of BTBD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BTBD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BTBD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BTBD3	hsa-miR-607	98.9489	NM_001282550
BTBD3	hsa-miR-4262	98.1891	NM_001282550
BTBD3	hsa-miR-205-5p	97.9907	NM_001282550
BTBD3	hsa-miR-4789-5p	97.6105	NM_001282550
BTBD3	hsa-miR-181b-5p	97.4326	NM_001282550
BTBD3	hsa-miR-181c-5p	97.4326	NM_001282550
BTBD3	hsa-miR-181a-5p	97.4326	NM_001282550
BTBD3	hsa-miR-181d-5p	97.4326	NM_001282550
BTBD3	hsa-let-7a-3p	97.2986	NM_001282550
BTBD3	hsa-miR-98-3p	97.2986	NM_001282550
BTBD3	hsa-let-7f-1-3p	97.2986	NM_001282550
BTBD3	hsa-let-7b-3p	97.2986	NM_001282550
BTBD3	hsa-miR-148b-3p	96.2275	NM_001282550
BTBD3	hsa-miR-148a-3p	96.2275	NM_001282550
BTBD3	hsa-miR-152-3p	96.2275	NM_001282550
BTBD3	hsa-miR-6792-5p	94.1117	NM_001282554
BTBD3	hsa-miR-454-3p	92.6477	NM_001282550
BTBD3	hsa-miR-302c-5p	92.3564	NM_001282554
BTBD3	hsa-miR-101-3p	91.9128	NM_001282554
BTBD3	hsa-miR-187-5p	91.6753	NM_001282550
BTBD3	hsa-miR-12135	91.4044	NM_001282554
BTBD3	hsa-miR-3682-5p	90.9927	NM_001282554
BTBD3	hsa-miR-3924	90.9277	NM_001282554
BTBD3	hsa-miR-323a-3p	90.7203	NM_001282554
BTBD3	hsa-miR-8084	90.5744	NM_001282550
BTBD3	hsa-miR-1185-1-3p	89.5019	NM_001282550
BTBD3	hsa-let-7f-2-3p	89.5019	NM_001282550
BTBD3	hsa-miR-1185-2-3p	89.5019	NM_001282550
BTBD3	hsa-miR-3668	89.102	NM_001282554
BTBD3	hsa-miR-301b-3p	89.083	NM_001282550
BTBD3	hsa-miR-130b-3p	89.083	NM_001282550
BTBD3	hsa-miR-4295	89.083	NM_001282550
BTBD3	hsa-miR-130a-3p	89.083	NM_001282550
BTBD3	hsa-miR-301a-3p	89.083	NM_001282550
BTBD3	hsa-miR-3666	89.083	NM_001282550
BTBD3	hsa-miR-1208	88.8608	NM_001282550
BTBD3	hsa-miR-6868-3p	88.0454	NM_001282550
BTBD3	hsa-miR-4799-5p	87.8714	NM_001282554
BTBD3	hsa-miR-6740-3p	87.7248	NM_001282554
BTBD3	hsa-miR-5692a	87.559	NM_001282550
BTBD3	hsa-miR-5197-5p	86.8066	NM_001282550
BTBD3	hsa-miR-186-5p	86.6425	NM_001282554
BTBD3	hsa-miR-4793-3p	86.5083	NM_001282550
BTBD3	hsa-miR-133a-3p	86.4942	NM_001282550
BTBD3	hsa-miR-133b	86.4942	NM_001282550
BTBD3	hsa-miR-5687	86.2744	NM_001282554
BTBD3	hsa-miR-6502-3p	85.227	NM_001282554
BTBD3	hsa-miR-548o-3p	85.0023	NM_001282550
BTBD3	hsa-miR-1323	85.0023	NM_001282550
BTBD3	hsa-miR-4276	84.0991	NM_001282550

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Motifs and transcription factors (TFs) regulating BTBD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BTBD3	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
BTBD3	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
BTBD3	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
BTBD3	transfac_pro__M06035	ZNF749 (directAnnotation).
BTBD3	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
BTBD3	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
BTBD3	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
BTBD3	metacluster_35.7	HINFP (inferredBy_Orthology).
BTBD3	metacluster_98.1	ZNF524 (directAnnotation).
BTBD3	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
BTBD3	cisbp__M04023	CREB1 (directAnnotation).
BTBD3	jaspar__MA0039.4	KLF4 (directAnnotation).
BTBD3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
BTBD3	transfac_pro__M04746	E2F1 (directAnnotation).
BTBD3	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
BTBD3	tfdimers__MD00457	SREBF1; SREBF2; ZNF354C (directAnnotation).
BTBD3	transfac_pro__M04595	SALL2 (directAnnotation).
BTBD3	metacluster_135.11	NR2C2 (directAnnotation).
BTBD3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BTBD3	tfdimers__MD00038	TFAP2C (directAnnotation).
BTBD3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BTBD3	metacluster_7.13	ZFX (directAnnotation).
BTBD3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BTBD3	cisbp__M00968	MTF2 (directAnnotation).
BTBD3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BTBD3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
BTBD3	cisbp__M00341	PAX6 (directAnnotation).
BTBD3	metacluster_198.3	ZFP64 (directAnnotation).
BTBD3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BTBD3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BTBD3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BTBD3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BTBD3	cisbp__M00788	ZFY (inferredBy_Orthology).
BTBD3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
BTBD3	metacluster_175.1	ZNF283 (directAnnotation).
BTBD3	hdpi__ZNF304	ZNF304 (directAnnotation).
BTBD3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BTBD3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
BTBD3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BTBD3	transfac_pro__M01199	TRIM28 (directAnnotation).
BTBD3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
BTBD3	metacluster_151.2	ZNF23 (directAnnotation).
BTBD3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BTBD3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BTBD3	transfac_pro__M03806	ZBTB7C (directAnnotation).
BTBD3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."