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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BRD1

Summary for BRD1

Gene information	Gene symbol	BRD1
	Ensembl ID	ENSG00000100425
	Entrez ID	23774
	Gene name	bromodomain containing 1
	Synonyms	BRL\|BRPF2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BRD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.439999	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.267677	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.273184	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.500698	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.283357	1.88e-02

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Expression of BRD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BRD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BRD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BRD1	hsa-miR-1276	99.1261	NM_001304808
BRD1	hsa-miR-3163	98.2937	NM_001304808
BRD1	hsa-miR-340-5p	97.7371	NM_001304808
BRD1	hsa-miR-548c-3p	97.7282	NM_001304808
BRD1	hsa-miR-5590-3p	95.5585	NM_001304808
BRD1	hsa-miR-142-5p	95.5585	NM_001304808
BRD1	hsa-miR-548av-5p	95.4506	NM_001304808
BRD1	hsa-miR-8054	95.4506	NM_001304808
BRD1	hsa-miR-548k	95.4506	NM_001304808
BRD1	hsa-miR-30e-5p	95.036	NM_001304808
BRD1	hsa-miR-30b-5p	95.036	NM_001304808
BRD1	hsa-miR-30d-5p	95.036	NM_001304808
BRD1	hsa-miR-30a-5p	95.036	NM_001304808
BRD1	hsa-miR-30c-5p	95.036	NM_001304808
BRD1	hsa-miR-5692a	94.9447	NM_001304808
BRD1	hsa-miR-1264	94.8034	NM_001304808
BRD1	hsa-miR-616-3p	94.3787	NM_001304808
BRD1	hsa-miR-98-3p	94.2779	NM_001304808
BRD1	hsa-let-7f-1-3p	94.2779	NM_001304808
BRD1	hsa-let-7a-3p	94.2779	NM_001304808
BRD1	hsa-let-7b-3p	94.2779	NM_001304808
BRD1	hsa-miR-4262	94.2771	NM_001304808
BRD1	hsa-miR-6782-3p	93.8582	NM_001304808
BRD1	hsa-miR-181c-5p	93.584	NM_001304808
BRD1	hsa-miR-181d-5p	93.584	NM_001304808
BRD1	hsa-miR-181a-5p	93.584	NM_001304808
BRD1	hsa-miR-181b-5p	93.584	NM_001304808
BRD1	hsa-miR-2115-3p	93.5409	NM_001304808
BRD1	hsa-miR-543	92.9135	NM_001304808
BRD1	hsa-miR-499b-3p	90.2355	NM_001304808
BRD1	hsa-miR-499a-3p	90.2355	NM_001304808
BRD1	hsa-miR-6835-3p	90.1368	NM_001304808
BRD1	hsa-miR-4422	90.1368	NM_001304808
BRD1	hsa-miR-1283	89.9715	NM_001304808
BRD1	hsa-miR-1271-3p	89.8764	NM_001304808
BRD1	hsa-miR-550a-3-5p	89.8764	NM_001304808
BRD1	hsa-miR-550a-5p	89.8764	NM_001304808
BRD1	hsa-miR-335-3p	89.4948	NM_001304808
BRD1	hsa-miR-5089-3p	89.3441	NM_001304808
BRD1	hsa-miR-4799-5p	88.9686	NM_001304808
BRD1	hsa-miR-6882-5p	87.359	NM_001304808
BRD1	hsa-miR-4666a-3p	86.7675	NM_001304808
BRD1	hsa-miR-4749-3p	86.495	NM_001304808
BRD1	hsa-miR-6793-3p	85.6777	NM_001304808
BRD1	hsa-miR-10527-5p	85.6295	NM_001304808
BRD1	hsa-miR-466	85.5794	NM_001304808
BRD1	hsa-let-7a-2-3p	84.523	NM_001304808
BRD1	hsa-let-7g-3p	84.523	NM_001304808
BRD1	hsa-miR-186-5p	83.4553	NM_001304808
BRD1	hsa-miR-381-3p	83.1826	NM_001304808

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Motifs and transcription factors (TFs) regulating BRD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BRD1	cisbp__M00788	ZFY (inferredBy_Orthology).
BRD1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BRD1	transfac_pro__M01199	TRIM28 (directAnnotation).
BRD1	metacluster_7.13	ZFX (directAnnotation).
BRD1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BRD1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
BRD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
BRD1	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
BRD1	jaspar__MA1721.1	ZNF93 (directAnnotation).
BRD1	transfac_pro__M04916	TAF1 (directAnnotation).
BRD1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
BRD1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BRD1	cisbp__M00249	WT1 (directAnnotation).
BRD1	hdpi__ZNF304	ZNF304 (directAnnotation).
BRD1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
BRD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
BRD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BRD1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
BRD1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
BRD1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
BRD1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
BRD1	transfac_pro__M01253	CNOT3 (directAnnotation).
BRD1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
BRD1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
BRD1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BRD1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
BRD1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
BRD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
BRD1	transfac_pro__M12697	ZNF142 (directAnnotation).
BRD1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
BRD1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
BRD1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
BRD1	transfac_pro__M01973	PLAG1 (directAnnotation).
BRD1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
BRD1	metacluster_143.13	ZBTB7A (directAnnotation).
BRD1	transfac_pro__M07387	ZBTB7A (directAnnotation).
BRD1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
BRD1	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
BRD1	metacluster_182.10	ZFX (directAnnotation).
BRD1	tfdimers__MD00038	TFAP2C (directAnnotation).
BRD1	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
BRD1	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
BRD1	tfdimers__MD00377	PBX1 (directAnnotation).
BRD1	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
BRD1	tfdimers__MD00232	CEBPB; TAF6; TBP (directAnnotation).
BRD1	tfdimers__MD00039	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
BRD1	tfdimers__MD00389	CRX (directAnnotation).
BRD1	taipale_tf_pairs__PBX4_HOXA10_CCATAAATCA_CAP	HOXA10; PBX4 (directAnnotation).
BRD1	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
BRD1	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."