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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: BRCC3

Summary for BRCC3

Gene information	Gene symbol	BRCC3
	Ensembl ID	ENSG00000185515
	Entrez ID	79184
	Gene name	BRCA1/BRCA2-containing complex subunit 3
	Synonyms	BRCC36\|C6.1A\|CXorf53
	Gene type	protein_coding
	UniProtAcc	P46736

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Dataset with differentially expressed gene: BRCC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.440137	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.293482	2.60e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.266767	7.42e-08

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Expression of BRCC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BRCC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BRCC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BRCC3	hsa-miR-877-3p	98.9656	NM_024332
BRCC3	hsa-miR-4424	93.2779	NM_024332
BRCC3	hsa-miR-4635	92.8686	NM_024332
BRCC3	hsa-miR-1294	92.0664	NM_024332
BRCC3	hsa-miR-9986	92.0664	NM_024332
BRCC3	hsa-miR-6881-3p	90.9919	NM_024332
BRCC3	hsa-miR-335-3p	90.6215	NM_024332
BRCC3	hsa-miR-579-3p	90.5821	NM_024332
BRCC3	hsa-miR-664b-3p	90.5821	NM_024332
BRCC3	hsa-miR-4775	88.3449	NM_024332
BRCC3	hsa-miR-1264	86.6342	NM_024332
BRCC3	hsa-miR-4659b-3p	84.9354	NM_024332
BRCC3	hsa-miR-4659a-3p	84.9354	NM_024332
BRCC3	hsa-miR-5696	84.2552	NM_024332
BRCC3	hsa-miR-6727-5p	84.23	NM_024332
BRCC3	hsa-miR-383-5p	83.3303	NM_024332
BRCC3	hsa-miR-518c-5p	83.1536	NM_024332
BRCC3	hsa-miR-3191-5p	81.3473	NM_024332
BRCC3	hsa-miR-125b-2-3p	81.2581	NM_024332

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Motifs and transcription factors (TFs) regulating BRCC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BRCC3	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
BRCC3	"Zinc acetate"	DB14487	small molecule
BRCC3	"Zinc chloride"	DB14533	small molecule
BRCC3	"Zinc sulfate, unspecified form"	DB14548	small molecule
BRCC3	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."