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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BPGM

Summary for BPGM

Gene information	Gene symbol	BPGM
	Ensembl ID	ENSG00000172331
	Entrez ID	669
	Gene name	bisphosphoglycerate mutase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P07738

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Dataset with differentially expressed gene: BPGM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.719753	2.80e-44
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.400489	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.436223	2.21e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.299425	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	1.17969	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.293028	3.88e-18

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Expression of BPGM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BPGM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BPGM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BPGM	hsa-miR-214-5p	92.5219	NM_001724
BPGM	hsa-miR-4704-3p	89.0188	NM_001724
BPGM	hsa-miR-7108-5p	88.4488	NM_001724
BPGM	hsa-miR-6866-3p	86.4026	NM_001724
BPGM	hsa-miR-188-5p	86.4026	NM_001724
BPGM	hsa-miR-4743-3p	85.5548	NM_001724
BPGM	hsa-miR-3613-3p	85.1885	NM_001724
BPGM	hsa-miR-432-5p	84.9597	NM_001724
BPGM	hsa-miR-520f-5p	84.5307	NM_001724
BPGM	hsa-miR-873-5p	83.6592	NM_001724
BPGM	hsa-miR-4531	83.1693	NM_001724
BPGM	hsa-miR-6715a-3p	80.8725	NM_001724

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Motifs and transcription factors (TFs) regulating BPGM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BPGM	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
BPGM	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
BPGM	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
BPGM	jaspar__MA1483.2	ELF2 (directAnnotation).
BPGM	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
BPGM	cisbp__M08198	ELF1 (directAnnotation).
BPGM	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
BPGM	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
BPGM	jaspar__MA0033.2	FOXL1 (directAnnotation).
BPGM	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
BPGM	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
BPGM	dbtfbs__ZNF157_HEK293_ENCSR564YYW_merged_N1	ZNF157 (directAnnotation).
BPGM	transfac_pro__M03892	RXRA; VDR (directAnnotation).
BPGM	tfdimers__MD00046	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6; SMAD4 (directAnnotation).
BPGM	taipale__NR2F1_full_RRGGTCAN_repr	NR2F1 (directAnnotation).
BPGM	tfdimers__MD00275	POU2F1; TFAP2A (directAnnotation).
BPGM	metacluster_79.33	YBX1; YBX1; ZNF264 (directAnnotation).
BPGM	metacluster_27.6	ZNF410; ZNF410 (directAnnotation).
BPGM	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
BPGM	transfac_pro__M06500	ZNF614 (directAnnotation).
BPGM	transfac_pro__M06398	ZNF761 (directAnnotation).
BPGM	homer__AGRGGTCA_COUP-TFII	NR2F2 (inferredBy_Orthology).
BPGM	taipale_tf_pairs__PITX1_FIGLA_TAATCCNNNNCASSTG_CAP_repr	FIGLA; PITX1 (directAnnotation).
BPGM	metacluster_64.2	NR2F2 (inferredBy_Orthology).
BPGM	transfac_pro__M05956	BCL11B (directAnnotation).
BPGM	transfac_pro__M06641	ZNF184 (directAnnotation).
BPGM	transfac_pro__M06435	ZNF429 (directAnnotation).
BPGM	metacluster_93.4	BCL6B (directAnnotation).
BPGM	taipale_tf_pairs__ERF_EOMES_TNTCACACCGGAAAT_CAP	EOMES; ERF (directAnnotation).
BPGM	transfac_pro__M06600	ZNF566 (directAnnotation).
BPGM	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BPGM	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
BPGM	transfac_pro__M06408	ZSCAN30 (directAnnotation).
BPGM	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
BPGM	transfac_pro__M06799	ZSCAN12 (directAnnotation).
BPGM	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BPGM	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
BPGM	metacluster_141.2	E2F2; E2F3 (directAnnotation).
BPGM	transfac_public__M00039	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."