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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: BORCS7

Summary for BORCS7

Gene informationGene symbol

BORCS7

Ensembl ID

ENSG00000166275

Entrez ID

119032

Gene nameBLOC-1 related complex subunit 7
SynonymsC10orf32|FLJ40752
Gene typeprotein_coding
UniProtAcc

Q96B45


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Dataset with differentially expressed gene: BORCS7

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells0.9098566.14e-08

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.4450291.04e-27

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Expression of BORCS7 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to BORCS7

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BORCS7

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
BORCS7hsa-miR-1213197.6985NM_001136200
BORCS7hsa-miR-127896.5665NM_001136200
BORCS7hsa-miR-477391.7004NM_001136200
BORCS7hsa-miR-443491.5683NM_001136200
BORCS7hsa-miR-451691.5683NM_001136200
BORCS7hsa-miR-889-3p91.4754NM_001136200
BORCS7hsa-miR-4699-3p91.3231NM_001136200
BORCS7hsa-miR-807590.9613NM_144591
BORCS7hsa-miR-580-5p90.9378NM_001136200
BORCS7hsa-miR-627-3p89.2932NM_001136200
BORCS7hsa-miR-2115-5p89.2203NM_001136200
BORCS7hsa-miR-4716-5p88.89NM_144591
BORCS7hsa-miR-570388.7154NM_001136200
BORCS7hsa-miR-124-5p88.2288NM_001136200
BORCS7hsa-miR-2681-5p87.7701NM_144591
BORCS7hsa-miR-59187.136NM_001136200
BORCS7hsa-miR-62086.5252NM_001136200
BORCS7hsa-miR-58786.3514NM_144591
BORCS7hsa-miR-548p85.0628NM_144591
BORCS7hsa-miR-684484.6119NM_001136200
BORCS7hsa-miR-6730-5p84.4585NM_144591
BORCS7hsa-miR-302d-5p83.5404NM_144591
BORCS7hsa-miR-302b-5p83.5404NM_144591
BORCS7hsa-miR-127082.1213NM_001136200
BORCS7hsa-miR-211781.7462NM_144591
BORCS7hsa-miR-6885-3p81.1036NM_001136200
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Motifs and transcription factors (TFs) regulating BORCS7

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
BORCS7metacluster_160.20JUND; PRDM15 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."