Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BNIP2

Summary for BNIP2

Gene information	Gene symbol	BNIP2
	Ensembl ID	ENSG00000140299
	Entrez ID	663
	Gene name	BCL2 interacting protein 2
	Synonyms	BNIP-2\|Nip2
	Gene type	protein_coding
	UniProtAcc	Q12982

Top

Dataset with differentially expressed gene: BNIP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.350581	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.280043	4.15e-09
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.337461	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.271826	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.385425	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.538101	3.92e-02

Top

Expression of BNIP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to BNIP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
BNIP2	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating BNIP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BNIP2	hsa-miR-3163	99.2212	NM_001320674
BNIP2	hsa-miR-548aw	99.1751	NM_001320674
BNIP2	hsa-miR-5011-5p	98.3985	NM_001320674
BNIP2	hsa-miR-194-5p	97.3985	NM_001320674
BNIP2	hsa-miR-20a-5p	97.3371	NM_001320674
BNIP2	hsa-miR-1468-3p	96.9681	NM_001320674
BNIP2	hsa-miR-4703-5p	96.8437	NM_001320674
BNIP2	hsa-miR-548f-5p	96.8011	NM_001320674
BNIP2	hsa-miR-20b-5p	96.6987	NM_001320674
BNIP2	hsa-miR-19a-3p	96.5535	NM_001320674
BNIP2	hsa-miR-19b-3p	96.5535	NM_001320674
BNIP2	hsa-miR-4766-3p	96.484	NM_001320674
BNIP2	hsa-miR-106b-5p	96.4312	NM_001320674
BNIP2	hsa-miR-7-1-3p	96.2958	NM_001320674
BNIP2	hsa-miR-7-2-3p	96.2958	NM_001320674
BNIP2	hsa-miR-548x-5p	96.2854	NM_001320674
BNIP2	hsa-miR-548g-5p	96.2854	NM_001320674
BNIP2	hsa-miR-548aj-5p	96.2854	NM_001320674
BNIP2	hsa-miR-3942-5p	96.1134	NM_001320674
BNIP2	hsa-miR-4680-3p	96.0153	NM_001320674
BNIP2	hsa-miR-6507-3p	95.6992	NM_001320674
BNIP2	hsa-miR-17-5p	95.6463	NM_001320674
BNIP2	hsa-miR-93-5p	95.6463	NM_001320674
BNIP2	hsa-miR-519d-3p	95.6463	NM_001320674
BNIP2	hsa-miR-526b-3p	95.6463	NM_001320674
BNIP2	hsa-miR-106a-5p	95.6463	NM_001320674
BNIP2	hsa-miR-5700	95.4587	NM_001320674
BNIP2	hsa-miR-3613-3p	94.8022	NM_001320674
BNIP2	hsa-miR-586	94.6069	NM_001320674
BNIP2	hsa-miR-2117	93.7279	NM_001320674
BNIP2	hsa-miR-548c-3p	93.1075	NM_001320674
BNIP2	hsa-miR-1252-3p	93.025	NM_001320674
BNIP2	hsa-miR-520h	92.6705	NM_001320674
BNIP2	hsa-miR-520g-3p	92.6705	NM_001320674
BNIP2	hsa-miR-6875-3p	92.0181	NM_001320674
BNIP2	hsa-miR-190a-3p	91.6037	NM_001320674
BNIP2	hsa-miR-3671	91.0938	NM_001320674
BNIP2	hsa-miR-5590-3p	90.8484	NM_001320674
BNIP2	hsa-miR-142-5p	90.8484	NM_001320674
BNIP2	hsa-miR-371b-3p	90.6609	NM_001320674
BNIP2	hsa-miR-4684-3p	90.6259	NM_001320674
BNIP2	hsa-miR-548ad-3p	90.336	NM_001320674
BNIP2	hsa-miR-551b-5p	89.9127	NM_001320674
BNIP2	hsa-miR-500a-5p	89.7568	NM_001320674
BNIP2	hsa-miR-6780b-3p	88.756	NM_001320674
BNIP2	hsa-miR-146a-3p	88.1159	NM_001320674
BNIP2	hsa-miR-597-3p	87.7599	NM_001320674
BNIP2	hsa-miR-3908	87.6318	NM_001320674
BNIP2	hsa-miR-657	86.6643	NM_001320674
BNIP2	hsa-miR-369-3p	86.4417	NM_001320674

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating BNIP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BNIP2	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BNIP2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
BNIP2	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
BNIP2	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
BNIP2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
BNIP2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
BNIP2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
BNIP2	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
BNIP2	hdpi__TIMELESS	TIMELESS (directAnnotation).
BNIP2	metacluster_191.5	SPDEF (inferredBy_Orthology).
BNIP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BNIP2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
BNIP2	hdpi__ELF2	ELF2 (directAnnotation).
BNIP2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
BNIP2	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
BNIP2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
BNIP2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
BNIP2	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
BNIP2	metacluster_141.2	E2F2; E2F3 (directAnnotation).
BNIP2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
BNIP2	jaspar__MA1483.2	ELF2 (directAnnotation).
BNIP2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
BNIP2	metacluster_172.6	CHD2; E2F1 (directAnnotation).
BNIP2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
BNIP2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
BNIP2	hdpi__FLI1	FLI1 (directAnnotation).
BNIP2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
BNIP2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
BNIP2	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
BNIP2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
BNIP2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
BNIP2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
BNIP2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
BNIP2	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
BNIP2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
BNIP2	hdpi__ETV4	ETV4 (directAnnotation).
BNIP2	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
BNIP2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
BNIP2	jaspar__MA1708.1	ETV7 (directAnnotation).
BNIP2	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
BNIP2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
BNIP2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."