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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: BMPR2

Summary for BMPR2

Gene information	Gene symbol	BMPR2
	Ensembl ID	ENSG00000204217
	Entrez ID	659
	Gene name	bone morphogenetic protein receptor type 2
	Synonyms	BMPR-II\|BMPR3\|BRK-3\|PPH1\|T-ALK
	Gene type	protein_coding
	UniProtAcc	Q13873

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Dataset with differentially expressed gene: BMPR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.419875	6.35e-37
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.314485	0.00e+00

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Expression of BMPR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BMPR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BMPR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BMPR2	hsa-miR-5692a	99.9834	NM_001204
BMPR2	hsa-miR-1468-3p	99.8398	NM_001204
BMPR2	hsa-miR-548aw	99.7704	NM_001204
BMPR2	hsa-miR-6885-3p	99.5334	NM_001204
BMPR2	hsa-miR-3617-3p	99.4107	NM_001204
BMPR2	hsa-miR-607	99.2435	NM_001204
BMPR2	hsa-miR-3163	99.1563	NM_001204
BMPR2	hsa-miR-4422	99.003	NM_001204
BMPR2	hsa-miR-4282	98.9363	NM_001204
BMPR2	hsa-miR-548az-5p	98.8121	NM_001204
BMPR2	hsa-miR-548t-5p	98.8121	NM_001204
BMPR2	hsa-miR-12123	98.7054	NM_001204
BMPR2	hsa-miR-3182	98.4154	NM_001204
BMPR2	hsa-miR-19b-3p	98.2477	NM_001204
BMPR2	hsa-miR-19a-3p	98.2477	NM_001204
BMPR2	hsa-miR-548c-3p	98.059	NM_001204
BMPR2	hsa-miR-548f-5p	98.0097	NM_001204
BMPR2	hsa-miR-548g-5p	98.0097	NM_001204
BMPR2	hsa-miR-548aj-5p	98.0097	NM_001204
BMPR2	hsa-miR-548x-5p	98.0097	NM_001204
BMPR2	hsa-miR-1322	97.9807	NM_001204
BMPR2	hsa-miR-3688-3p	97.553	NM_001204
BMPR2	hsa-miR-544a	97.3494	NM_001204
BMPR2	hsa-miR-651-3p	97.3453	NM_001204
BMPR2	hsa-miR-3646	95.9838	NM_001204
BMPR2	hsa-miR-6835-3p	95.4003	NM_001204
BMPR2	hsa-miR-545-3p	95.2217	NM_001204
BMPR2	hsa-miR-374a-3p	95.087	NM_001204
BMPR2	hsa-miR-4517	95.0261	NM_001204
BMPR2	hsa-miR-361-5p	94.3902	NM_001204
BMPR2	hsa-miR-548n	94.1169	NM_001204
BMPR2	hsa-miR-1252-5p	93.6346	NM_001204
BMPR2	hsa-miR-494-3p	93.5811	NM_001204
BMPR2	hsa-miR-6079	93.0559	NM_001204
BMPR2	hsa-miR-4775	92.9348	NM_001204
BMPR2	hsa-miR-590-3p	92.9334	NM_001204
BMPR2	hsa-miR-593-3p	92.7934	NM_001204
BMPR2	hsa-miR-20b-5p	92.6534	NM_001204
BMPR2	hsa-miR-519d-3p	92.6534	NM_001204
BMPR2	hsa-miR-93-5p	92.6534	NM_001204
BMPR2	hsa-miR-17-5p	92.6534	NM_001204
BMPR2	hsa-miR-20a-5p	92.5744	NM_001204
BMPR2	hsa-miR-106a-5p	92.5744	NM_001204
BMPR2	hsa-miR-106b-5p	92.5744	NM_001204
BMPR2	hsa-miR-1258	92.4901	NM_001204
BMPR2	hsa-miR-548ar-3p	92.4849	NM_001204
BMPR2	hsa-miR-526b-3p	92.4063	NM_001204
BMPR2	hsa-miR-7856-5p	92.3701	NM_001204
BMPR2	hsa-miR-3671	92.2496	NM_001204
BMPR2	hsa-miR-651-5p	92.2443	NM_001204

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Motifs and transcription factors (TFs) regulating BMPR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BMPR2	metacluster_151.2	ZNF23 (directAnnotation).
BMPR2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BMPR2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BMPR2	jaspar__MA0748.2	YY2 (directAnnotation).
BMPR2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
BMPR2	"Dibotermin alfa"	DB11639	biotech
BMPR2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."