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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: BMP2K

Summary for BMP2K

Gene information	Gene symbol	BMP2K
	Ensembl ID	ENSG00000138756
	Entrez ID	55589
	Gene name	BMP2 inducible kinase
	Synonyms	BIKe\|DKFZp434K0614
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BMP2K

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.257077	5.03e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.294027	8.78e-07

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Expression of BMP2K in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BMP2K

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BMP2K

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BMP2K	hsa-miR-302c-5p	96.0688	NM_017593
BMP2K	hsa-miR-1468-3p	94.8332	NM_017593
BMP2K	hsa-miR-186-5p	94.829	NM_017593
BMP2K	hsa-miR-4803	94.188	NM_017593
BMP2K	hsa-miR-543	94.0045	NM_017593
BMP2K	hsa-miR-3143	93.1055	NM_017593
BMP2K	hsa-miR-510-3p	91.6241	NM_198892
BMP2K	hsa-miR-548ah-5p	91.345	NM_017593
BMP2K	hsa-miR-3609	91.345	NM_017593
BMP2K	hsa-miR-659-3p	91.1625	NM_198892
BMP2K	hsa-miR-105-5p	88.9633	NM_017593
BMP2K	hsa-miR-7853-5p	88.9633	NM_017593
BMP2K	hsa-miR-4716-5p	88.1381	NM_017593
BMP2K	hsa-miR-6839-3p	88.0357	NM_017593
BMP2K	hsa-miR-607	87.8075	NM_198892
BMP2K	hsa-miR-4262	87.5413	NM_017593
BMP2K	hsa-miR-299-5p	87.3137	NM_198892
BMP2K	hsa-miR-216b-3p	86.8216	NM_198892
BMP2K	hsa-miR-651-5p	86.7283	NM_017593
BMP2K	hsa-miR-4287	84.7575	NM_017593
BMP2K	hsa-miR-4685-3p	84.7575	NM_017593
BMP2K	hsa-miR-181a-5p	84.3381	NM_017593
BMP2K	hsa-miR-181d-5p	84.3381	NM_017593
BMP2K	hsa-miR-181b-5p	84.3381	NM_017593
BMP2K	hsa-miR-181c-5p	84.3381	NM_017593
BMP2K	hsa-miR-3617-3p	84.0214	NM_017593
BMP2K	hsa-miR-494-3p	83.39	NM_017593
BMP2K	hsa-miR-629-5p	83.337	NM_017593
BMP2K	hsa-miR-1250-3p	82.595	NM_017593
BMP2K	hsa-miR-5000-3p	82.1715	NM_017593
BMP2K	hsa-miR-5003-5p	82.0923	NM_017593
BMP2K	hsa-miR-3157-3p	81.9412	NM_017593
BMP2K	hsa-miR-874-3p	81.9412	NM_017593
BMP2K	hsa-miR-302d-5p	81.9405	NM_198892
BMP2K	hsa-miR-302b-5p	81.9405	NM_198892

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Motifs and transcription factors (TFs) regulating BMP2K

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BMP2K	metacluster_135.11	NR2C2 (directAnnotation).
BMP2K	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BMP2K	taipale_tf_pairs__GCM1_NHLH1_NCAGCTGNNNNNNNTRCGGG_CAP_repr	GCM1; NHLH1 (directAnnotation).
BMP2K	jaspar__MA1122.1	TFDP1 (directAnnotation).
BMP2K	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BMP2K	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
BMP2K	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
BMP2K	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
BMP2K	metacluster_22.13	MAFK (inferredBy_Orthology).
BMP2K	transfac_pro__M06402	ZNF493 (directAnnotation).
BMP2K	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
BMP2K	metacluster_22.25	NFE2L2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
BMP2K	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."