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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BMP2

Summary for BMP2

Gene information	Gene symbol	BMP2
	Ensembl ID	ENSG00000125845
	Entrez ID	650
	Gene name	bone morphogenetic protein 2
	Synonyms	BMP2A
	Gene type	protein_coding
	UniProtAcc	P12643

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Dataset with differentially expressed gene: BMP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.55756	2.47e-17

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Expression of BMP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BMP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BMP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BMP2	hsa-miR-5011-5p	100	NM_001200
BMP2	hsa-miR-190a-3p	99.9999	NM_001200
BMP2	hsa-miR-4531	99.6725	NM_001200
BMP2	hsa-miR-12131	99.477	NM_001200
BMP2	hsa-miR-1277-5p	99.402	NM_001200
BMP2	hsa-miR-4796-3p	98.7072	NM_001200
BMP2	hsa-miR-5571-5p	98.4641	NM_001200
BMP2	hsa-miR-8485	98.2516	NM_001200
BMP2	hsa-miR-140-5p	97.7712	NM_001200
BMP2	hsa-miR-450a-1-3p	96.4067	NM_001200
BMP2	hsa-miR-4324	96.3005	NM_001200
BMP2	hsa-miR-374a-5p	94.1898	NM_001200
BMP2	hsa-miR-587	93.9033	NM_001200
BMP2	hsa-miR-374b-5p	93.8367	NM_001200
BMP2	hsa-miR-3686	93.287	NM_001200
BMP2	hsa-miR-3920	93.2233	NM_001200
BMP2	hsa-miR-302c-5p	92.9177	NM_001200
BMP2	hsa-miR-3978	92.2296	NM_001200
BMP2	hsa-miR-5692b	91.5478	NM_001200
BMP2	hsa-miR-5692c	91.5478	NM_001200
BMP2	hsa-miR-1264	89.2556	NM_001200
BMP2	hsa-miR-487b-5p	88.5014	NM_001200
BMP2	hsa-miR-487a-5p	88.5014	NM_001200
BMP2	hsa-miR-6813-3p	88.0458	NM_001200
BMP2	hsa-miR-633	87.8695	NM_001200
BMP2	hsa-miR-4653-5p	87.5301	NM_001200
BMP2	hsa-miR-3921	87.5301	NM_001200
BMP2	hsa-miR-8068	86.7053	NM_001200
BMP2	hsa-miR-548az-5p	86.5064	NM_001200
BMP2	hsa-miR-548t-5p	86.5064	NM_001200
BMP2	hsa-miR-3145-3p	86.3945	NM_001200
BMP2	hsa-miR-369-3p	86.3441	NM_001200
BMP2	hsa-miR-4477b	86.3339	NM_001200
BMP2	hsa-miR-3147	86.256	NM_001200
BMP2	hsa-miR-1200	86.1088	NM_001200
BMP2	hsa-let-7c-3p	86.0766	NM_001200
BMP2	hsa-miR-301a-5p	85.3078	NM_001200
BMP2	hsa-miR-301b-5p	85.3078	NM_001200
BMP2	hsa-miR-146a-3p	85.3078	NM_001200
BMP2	hsa-miR-922	85.0131	NM_001200
BMP2	hsa-miR-6809-3p	84.1905	NM_001200
BMP2	hsa-miR-576-5p	83.462	NM_001200
BMP2	hsa-miR-4263	83.462	NM_001200
BMP2	hsa-miR-3924	82.9807	NM_001200
BMP2	hsa-miR-544b	82.5076	NM_001200
BMP2	hsa-miR-4482-3p	82.2291	NM_001200
BMP2	hsa-miR-7159-3p	80.7268	NM_001200
BMP2	hsa-miR-3163	80.4169	NM_001200

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Motifs and transcription factors (TFs) regulating BMP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BMP2	transfac_pro__M12697	ZNF142 (directAnnotation).
BMP2	cisbp__M00341	PAX6 (directAnnotation).
BMP2	jaspar__MA1650.1	ZBTB14 (directAnnotation).
BMP2	transfac_pro__M02089	E2F3 (directAnnotation).
BMP2	transfac_pro__M03806	ZBTB7C (directAnnotation).
BMP2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
BMP2	transfac_pro__M00322	MAX; MYC (directAnnotation).
BMP2	tfdimers__MD00483	ZBTB14 (directAnnotation).
BMP2	tfdimers__MD00364	WT1 (directAnnotation).
BMP2	transfac_pro__M04817	ZBTB33 (directAnnotation).
BMP2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BMP2	transfac_pro__M01253	CNOT3 (directAnnotation).
BMP2	taipale_tf_pairs__ERF_SREBF2_NNCACGTGACMGGAARNN_CAP_repr	ERF; SREBF2 (directAnnotation).
BMP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
BMP2	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."