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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BLZF1

Summary for BLZF1

Gene information	Gene symbol	BLZF1
	Ensembl ID	ENSG00000117475
	Entrez ID	8548
	Gene name	basic leucine zipper nuclear factor 1
	Synonyms	JEM-1
	Gene type	protein_coding
	UniProtAcc	Q9H2G9

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Dataset with differentially expressed gene: BLZF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.433326	0.00e+00

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Expression of BLZF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BLZF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BLZF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BLZF1	hsa-miR-1277-5p	99.4454	NM_001320973
BLZF1	hsa-miR-125b-5p	97.5295	NM_001320973
BLZF1	hsa-miR-125a-5p	97.5295	NM_001320973
BLZF1	hsa-miR-4319	97.1095	NM_001320973
BLZF1	hsa-miR-4795-3p	94.2221	NM_001320973
BLZF1	hsa-miR-539-5p	93.5829	NM_001320972
BLZF1	hsa-miR-3925-5p	92.1589	NM_001320972
BLZF1	hsa-miR-126-5p	91.9978	NM_001320973
BLZF1	hsa-miR-6833-3p	91.8691	NM_001320973
BLZF1	hsa-miR-5702	91.2656	NM_001320973
BLZF1	hsa-miR-3145-3p	91.1978	NM_003666
BLZF1	hsa-miR-500b-3p	91.1397	NM_003666
BLZF1	hsa-miR-582-5p	90.6432	NM_003666
BLZF1	hsa-miR-5692b	89.7553	NM_001320973
BLZF1	hsa-miR-5692c	89.7553	NM_001320973
BLZF1	hsa-miR-4324	87.993	NM_001320973
BLZF1	hsa-miR-6810-3p	86.9263	NM_001320973
BLZF1	hsa-miR-1303	86.9228	NM_001320972
BLZF1	hsa-miR-5586-5p	86.4065	NM_001320973
BLZF1	hsa-miR-890	85.6655	NM_001320972
BLZF1	hsa-miR-5011-5p	85.5483	NM_001320973
BLZF1	hsa-miR-367-5p	85.5185	NM_001320973
BLZF1	hsa-miR-6801-3p	85.4848	NM_001320973
BLZF1	hsa-miR-577	85.3972	NM_001320973
BLZF1	hsa-miR-568	85.271	NM_001320973
BLZF1	hsa-miR-576-5p	84.748	NM_003666
BLZF1	hsa-miR-3163	84.5156	NM_001320973
BLZF1	hsa-miR-6832-3p	84.2298	NM_003666
BLZF1	hsa-miR-4477a	84.2033	NM_001320973
BLZF1	hsa-miR-7848-3p	84.1248	NM_001320973
BLZF1	hsa-miR-5007-5p	83.9032	NM_001320973
BLZF1	hsa-miR-4772-3p	83.6952	NM_001320973
BLZF1	hsa-miR-6885-3p	83.1257	NM_003666
BLZF1	hsa-miR-8057	83.0746	NM_001320973
BLZF1	hsa-miR-4753-3p	82.7696	NM_001320972
BLZF1	hsa-miR-6778-3p	82.741	NM_003666
BLZF1	hsa-miR-6131	81.9971	NM_001320972
BLZF1	hsa-miR-6866-5p	81.3598	NM_003666
BLZF1	hsa-miR-4768-5p	81.3074	NM_001320973
BLZF1	hsa-miR-6772-5p	80.3008	NM_001320973

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Motifs and transcription factors (TFs) regulating BLZF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BLZF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."