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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: BLVRA

Summary for BLVRA

Gene information	Gene symbol	BLVRA
	Ensembl ID	ENSG00000106605
	Entrez ID	644
	Gene name	biliverdin reductase A
	Synonyms	BLVR
	Gene type	protein_coding
	UniProtAcc	P53004

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Dataset with differentially expressed gene: BLVRA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.597	1.14e-04
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.377491	1.07e-13
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.264605	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.258206	2.41e-37
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.278083	5.78e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.417292	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.310503	1.61e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.383263	2.62e-19

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Expression of BLVRA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BLVRA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BLVRA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BLVRA	hsa-miR-6793-3p	95.9847	NM_001253823
BLVRA	hsa-miR-4775	94.4838	NM_001253823
BLVRA	hsa-miR-590-3p	88.3689	NM_001253823
BLVRA	hsa-miR-3658	86.8479	NM_001253823

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Motifs and transcription factors (TFs) regulating BLVRA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BLVRA	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
BLVRA	transfac_pro__M06035	ZNF749 (directAnnotation).
BLVRA	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
BLVRA	transfac_pro__M04617	ZBTB7A (directAnnotation).
BLVRA	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
BLVRA	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
BLVRA	transfac_pro__M07387	ZBTB7A (directAnnotation).
BLVRA	transfac_pro__M07436	WT1 (directAnnotation).
BLVRA	transfac_pro__M00716	ZBTB14 (directAnnotation).
BLVRA	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BLVRA	transfac_pro__M04893	TAF1 (directAnnotation).
BLVRA	transfac_pro__M03876	ZBTB33 (directAnnotation).
BLVRA	jaspar__MA1509.1	IRF6 (directAnnotation).
BLVRA	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
BLVRA	transfac_pro__M05743	ZNF57 (directAnnotation).
BLVRA	metacluster_22.33	MAFK (inferredBy_Orthology).
BLVRA	taipale_cyt_meth__IRF6_ACCGAWACY_FL_meth	IRF6 (directAnnotation).
BLVRA	metacluster_22.1	MAFF (inferredBy_Orthology).
BLVRA	transfac_pro__M12556	ETV4 (directAnnotation).
BLVRA	taipale_tf_pairs__RFX3_ETV7_NNNMGGAANNNNNTCCNNNRCAACN_CAP_repr	ETV7; RFX3 (directAnnotation).
BLVRA	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
BLVRA	taipale_tf_pairs__HOXA3_EOMES_TAATKAGGTGNKA_CAP_repr	EOMES; HOXA3 (directAnnotation).
BLVRA	transfac_pro__M05392	SCRT2 (inferredBy_Orthology).
BLVRA	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
BLVRA	transfac_pro__M06237	ZNF846 (directAnnotation).
BLVRA	tfdimers__MD00362	ARID3A; BCL6 (directAnnotation).
BLVRA	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
BLVRA	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
BLVRA	metacluster_22.19	NFE2 (directAnnotation).
BLVRA	transfac_pro__M06111	ZNF254 (directAnnotation).
BLVRA	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
BLVRA	jaspar__MA1154.1	ZNF282 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
BLVRA	"NADH"	DB00157	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."