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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BLOC1S6

Summary for BLOC1S6

Gene information	Gene symbol	BLOC1S6
	Ensembl ID	ENSG00000104164
	Entrez ID	26258
	Gene name	biogenesis of lysosomal organelles complex 1 subunit 6
	Synonyms	HPS9\|PA\|PLDN
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BLOC1S6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.291953	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.279012	1.90e-07
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.305454	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.399014	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.35216	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.381089	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.422282	8.36e-25

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Expression of BLOC1S6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BLOC1S6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BLOC1S6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BLOC1S6	hsa-miR-5692a	98.9385	NM_012388
BLOC1S6	hsa-miR-8063	96.4628	NM_012388
BLOC1S6	hsa-miR-607	95.5342	NM_001311256
BLOC1S6	hsa-miR-3973	95.1704	NM_012388
BLOC1S6	hsa-miR-548an	94.7228	NM_012388
BLOC1S6	hsa-miR-8068	94.6091	NM_012388
BLOC1S6	hsa-miR-10527-5p	94.428	NM_012388
BLOC1S6	hsa-miR-130a-5p	94.3739	NM_001311256
BLOC1S6	hsa-miR-421	94.3331	NM_012388
BLOC1S6	hsa-miR-1305	92.425	NM_012388
BLOC1S6	hsa-miR-552-5p	91.6522	NM_001311256
BLOC1S6	hsa-miR-4262	91.6257	NM_001311256
BLOC1S6	hsa-miR-340-5p	90.5036	NM_012388
BLOC1S6	hsa-miR-9902	90.1702	NM_012388
BLOC1S6	hsa-miR-6508-5p	89.9786	NM_001311256
BLOC1S6	hsa-miR-8067	89.7741	NM_001311256
BLOC1S6	hsa-miR-890	89.4248	NM_012388
BLOC1S6	hsa-miR-181d-5p	88.1441	NM_001311256
BLOC1S6	hsa-miR-181b-5p	88.1441	NM_001311256
BLOC1S6	hsa-miR-181a-5p	88.1441	NM_001311256
BLOC1S6	hsa-miR-181c-5p	88.1441	NM_001311256
BLOC1S6	hsa-miR-4257	88.0102	NM_001311256
BLOC1S6	hsa-miR-664a-3p	87.9427	NM_001311256
BLOC1S6	hsa-miR-95-5p	87.7244	NM_012388
BLOC1S6	hsa-miR-4698	87.1868	NM_012388
BLOC1S6	hsa-miR-5580-3p	87.1256	NM_012388
BLOC1S6	hsa-miR-4503	85.3926	NM_012388
BLOC1S6	hsa-miR-7159-5p	85.155	NM_012388
BLOC1S6	hsa-miR-8056	84.7675	NM_012388
BLOC1S6	hsa-miR-124-3p	84.3856	NM_001311256
BLOC1S6	hsa-miR-506-3p	84.3856	NM_001311256
BLOC1S6	hsa-miR-6511a-3p	84.2613	NM_012388
BLOC1S6	hsa-miR-6511b-3p	84.2613	NM_012388
BLOC1S6	hsa-miR-4753-3p	83.5841	NM_001311256
BLOC1S6	hsa-miR-6809-3p	82.7415	NM_001311256
BLOC1S6	hsa-miR-1277-5p	82.3225	NM_012388
BLOC1S6	hsa-miR-590-3p	82.2138	NM_001311256
BLOC1S6	hsa-miR-5192	82.1823	NM_012388
BLOC1S6	hsa-miR-6804-5p	81.5112	NM_012388
BLOC1S6	hsa-miR-3671	81.0628	NM_012388

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Motifs and transcription factors (TFs) regulating BLOC1S6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BLOC1S6	transfac_pro__M02090	E2F4 (directAnnotation).
BLOC1S6	metacluster_135.11	NR2C2 (directAnnotation).
BLOC1S6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BLOC1S6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BLOC1S6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
BLOC1S6	metacluster_191.5	SPDEF (inferredBy_Orthology).
BLOC1S6	hdpi__TIMELESS	TIMELESS (directAnnotation).
BLOC1S6	cisbp__M00249	WT1 (directAnnotation).
BLOC1S6	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
BLOC1S6	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
BLOC1S6	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
BLOC1S6	hdpi__ELF2	ELF2 (directAnnotation).
BLOC1S6	transfac_pro__M01861	ATF1 (directAnnotation).
BLOC1S6	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
BLOC1S6	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
BLOC1S6	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
BLOC1S6	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."