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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BIRC6

Summary for BIRC6

Gene information	Gene symbol	BIRC6
	Ensembl ID	ENSG00000115760
	Entrez ID	57448
	Gene name	baculoviral IAP repeat containing 6
	Synonyms	BRUCE
	Gene type	protein_coding
	UniProtAcc	Q9NR09

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Dataset with differentially expressed gene: BIRC6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.420981	4.15e-39
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.294626	0.00e+00

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Expression of BIRC6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BIRC6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
BIRC6	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating BIRC6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BIRC6	hsa-miR-551b-5p	99.7259	NM_016252
BIRC6	hsa-miR-3671	99.2491	NM_016252
BIRC6	hsa-miR-3163	99.1799	NM_016252
BIRC6	hsa-miR-6844	98.2178	NM_016252
BIRC6	hsa-miR-4276	97.1689	NM_016252
BIRC6	hsa-miR-548s	96.657	NM_016252
BIRC6	hsa-miR-4755-5p	95.5982	NM_016252
BIRC6	hsa-miR-5006-3p	95.5982	NM_016252
BIRC6	hsa-miR-4262	95.466	NM_016252
BIRC6	hsa-miR-183-5p	94.5192	NM_016252
BIRC6	hsa-miR-3926	94.169	NM_016252
BIRC6	hsa-miR-181b-5p	94.008	NM_016252
BIRC6	hsa-miR-181a-5p	94.008	NM_016252
BIRC6	hsa-miR-181d-5p	94.008	NM_016252
BIRC6	hsa-miR-181c-5p	94.008	NM_016252
BIRC6	hsa-miR-6835-3p	93.0321	NM_016252
BIRC6	hsa-miR-6853-3p	92.9973	NM_016252
BIRC6	hsa-miR-543	92.8611	NM_016252
BIRC6	hsa-miR-4729	92.7538	NM_016252
BIRC6	hsa-miR-4736	92.7219	NM_016252
BIRC6	hsa-miR-9718	92.3859	NM_016252
BIRC6	hsa-miR-607	92.0557	NM_016252
BIRC6	hsa-miR-628-5p	91.92	NM_016252
BIRC6	hsa-miR-653-5p	91.6685	NM_016252
BIRC6	hsa-miR-497-3p	91.5877	NM_016252
BIRC6	hsa-miR-4761-3p	90.6516	NM_016252
BIRC6	hsa-miR-552-3p	90.5327	NM_016252
BIRC6	hsa-miR-5002-5p	89.8689	NM_016252
BIRC6	hsa-miR-6823-3p	89.7606	NM_016252
BIRC6	hsa-miR-597-3p	89.4466	NM_016252
BIRC6	hsa-miR-204-5p	89.304	NM_016252
BIRC6	hsa-miR-211-5p	89.304	NM_016252
BIRC6	hsa-miR-4789-5p	89.2054	NM_016252
BIRC6	hsa-miR-2114-3p	89.0691	NM_016252
BIRC6	hsa-miR-545-5p	88.9643	NM_016252
BIRC6	hsa-miR-8057	88.8977	NM_016252
BIRC6	hsa-miR-548e-5p	88.6149	NM_016252
BIRC6	hsa-miR-599	88.3261	NM_016252
BIRC6	hsa-miR-3945	87.5481	NM_016252
BIRC6	hsa-miR-486-5p	87.5402	NM_016252
BIRC6	hsa-miR-3124-3p	87.2239	NM_016252
BIRC6	hsa-miR-4801	87.2158	NM_016252
BIRC6	hsa-miR-1229-3p	87.1162	NM_016252
BIRC6	hsa-miR-3121-3p	86.8499	NM_016252
BIRC6	hsa-miR-623	86.4377	NM_016252
BIRC6	hsa-miR-544a	86.0841	NM_016252
BIRC6	hsa-miR-129-2-3p	85.9709	NM_016252
BIRC6	hsa-miR-129-1-3p	85.9709	NM_016252
BIRC6	hsa-miR-4703-3p	85.8891	NM_016252
BIRC6	hsa-miR-4446-5p	85.2465	NM_016252

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Motifs and transcription factors (TFs) regulating BIRC6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BIRC6	jaspar__MA1933.1	SREBF2 (directAnnotation).
BIRC6	metacluster_7.13	ZFX (directAnnotation).
BIRC6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BIRC6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BIRC6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
BIRC6	cisbp__M01863	ZNF711 (inferredBy_Orthology).
BIRC6	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
BIRC6	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
BIRC6	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
BIRC6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BIRC6	metacluster_198.3	ZFP64 (directAnnotation).
BIRC6	cisbp__M00968	MTF2 (directAnnotation).
BIRC6	transfac_pro__M00716	ZBTB14 (directAnnotation).
BIRC6	transfac_pro__M04893	TAF1 (directAnnotation).
BIRC6	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
BIRC6	transfac_pro__M02089	E2F3 (directAnnotation).
BIRC6	hdpi__NRL	NRL (directAnnotation).
BIRC6	hdpi__HIP2	UBE2K (directAnnotation).
BIRC6	transfac_pro__M01783	SP2 (directAnnotation).
BIRC6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
BIRC6	tfdimers__MD00483	ZBTB14 (directAnnotation).
BIRC6	hdpi__GTF3C2	GTF3C2 (directAnnotation).
BIRC6	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
BIRC6	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
BIRC6	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
BIRC6	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
BIRC6	hdpi__ZNF304	ZNF304 (directAnnotation).
BIRC6	metacluster_135.11	NR2C2 (directAnnotation).
BIRC6	cisbp__M00788	ZFY (inferredBy_Orthology).
BIRC6	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
BIRC6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BIRC6	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BIRC6	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BIRC6	cisbp__M00343	PAX6 (directAnnotation).
BIRC6	transfac_pro__M00430	E2F1 (directAnnotation).
BIRC6	transfac_pro__M12697	ZNF142 (directAnnotation).
BIRC6	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
BIRC6	transfac_pro__M00938	E2F1 (directAnnotation).
BIRC6	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
BIRC6	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
BIRC6	transfac_pro__M12694	ZFP14 (directAnnotation).
BIRC6	transfac_pro__M04617	ZBTB7A (directAnnotation).
BIRC6	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
BIRC6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BIRC6	transfac_pro__M02090	E2F4 (directAnnotation).
BIRC6	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
BIRC6	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
BIRC6	transfac_pro__M07437	ZBTB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."