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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BICDL1

Summary for BICDL1

Gene information	Gene symbol	BICDL1
	Ensembl ID	ENSG00000135127
	Entrez ID	92558
	Gene name	BICD family like cargo adaptor 1
	Synonyms	BICDR-1\|CCDC64\|FLJ26450
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: BICDL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.270148	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.350525	0.00e+00

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Expression of BICDL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BICDL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BICDL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BICDL1	hsa-miR-4728-5p	95.8567	NM_207311
BICDL1	hsa-miR-6785-5p	95.8567	NM_207311
BICDL1	hsa-miR-3924	95.0132	NM_207311
BICDL1	hsa-miR-149-3p	94.7021	NM_207311
BICDL1	hsa-miR-6883-5p	94.7021	NM_207311
BICDL1	hsa-miR-6127	91.951	NM_207311
BICDL1	hsa-miR-4668-3p	90.7765	NM_207311
BICDL1	hsa-miR-221-3p	88.6688	NM_207311
BICDL1	hsa-miR-222-3p	88.6688	NM_207311
BICDL1	hsa-miR-532-5p	87.6376	NM_207311
BICDL1	hsa-miR-765	86.6516	NM_207311
BICDL1	hsa-miR-190a-3p	86.1971	NM_207311
BICDL1	hsa-miR-6129	86.1426	NM_207311
BICDL1	hsa-miR-4510	86.1426	NM_207311
BICDL1	hsa-miR-6130	86.1426	NM_207311
BICDL1	hsa-miR-6133	86.1426	NM_207311
BICDL1	hsa-miR-656-3p	85.0378	NM_207311
BICDL1	hsa-miR-3163	84.9396	NM_207311
BICDL1	hsa-miR-11181-3p	83.1767	NM_207311
BICDL1	hsa-miR-4633-5p	81.5006	NM_207311
BICDL1	hsa-miR-10394-5p	81.2527	NM_207311
BICDL1	hsa-miR-1205	81.2527	NM_207311

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Motifs and transcription factors (TFs) regulating BICDL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BICDL1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
BICDL1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
BICDL1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
BICDL1	transfac_pro__M04893	TAF1 (directAnnotation).
BICDL1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
BICDL1	transfac_pro__M01199	TRIM28 (directAnnotation).
BICDL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BICDL1	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
BICDL1	hdpi__HIP2	UBE2K (directAnnotation).
BICDL1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
BICDL1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
BICDL1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
BICDL1	transfac_pro__M00938	E2F1 (directAnnotation).
BICDL1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
BICDL1	hdpi__RARA	RARA (directAnnotation).
BICDL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
BICDL1	jaspar__MA1583.1	ZFP57 (directAnnotation).
BICDL1	cisbp__M00968	MTF2 (directAnnotation).
BICDL1	transfac_pro__M02898	SMAD3 (directAnnotation).
BICDL1	jaspar__MA1721.1	ZNF93 (directAnnotation).
BICDL1	transfac_pro__M04916	TAF1 (directAnnotation).
BICDL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BICDL1	jaspar__MA1122.1	TFDP1 (directAnnotation).
BICDL1	transfac_pro__M07310	SP5 (directAnnotation).
BICDL1	hdpi__NRL	NRL (directAnnotation).
BICDL1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
BICDL1	hdpi__PDLIM5	PDLIM5 (directAnnotation).
BICDL1	transfac_pro__M04817	ZBTB33 (directAnnotation).
BICDL1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
BICDL1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
BICDL1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
BICDL1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
BICDL1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
BICDL1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BICDL1	transfac_pro__M07436	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."